Gilbert Foundation and American Fed for Aging Research award grants on Alzheimer's disease
...nd environmental factors play in brain plasticity, degeneration and cognitive decline using a novel magnetic resonance imaging (MRI) methodology called virtual-dot-com that allows for a greater sensitivity and specificity of the brain than conventional MRI. Olivier Boutaud, Ph.D., Research Assistant Professo...Taking a supplement of glycine helps prevent degenerative diseases such as arthrosis or osteoporosis
...of 65, and 80% of people over 75. It consists of a degeneration of the articulary cartilage which disappears until it leaves the subchondral bone exposed. Arthrosis has no cure at present and the most widely used treatments are pain-killers and NSAID (non-steroidal antiinflammatory drugs), which only relieve pain...Study identifies new gene therapy tools for inherited blindness
...are so many inherited forms of blindness linked to degeneration of photoreceptors." Corbo and colleagues began their studies with three genes previously shown to be important to regulation of photoreceptor proteins. The three genes, known as transcription factors, act by binding to DNA in a way that turns other g...News tips from the Journal of Neuroscience
...dle et al. examined whether reduced VMAT2 leads to degeneration of dopamine neurons. The authors examined mice that expressed 5% of the normal protein (VMAT2 LO). These mice showed elevated reactive oxygen species, age-related neurodegeneration in the striatum, reduced striatal dopamine levels, and a correspondin...Gene variant increases risk of blindness
...uch as reading and driving. Age-related macular degeneration (AMD), the cause of which is poorly understood, is the leading cause of visual loss in older people and the commonest cause of blindness in the USA and European countries. The researchers based their findings on studies of patients with AMD (603 f...Research study describes the role part of the brain plays in memory
...ne of the regions of the brain that shown signs of degeneration among those who suffer from Alzheimer's (and who are often treated with drugs that help to produce acetylcholine). The acetylcholine produced by the nucleus basalis is transferred to other regions of the brain, where it is "recognised" by receptor ...A gene that protects from kidney disease
...umans and mice. NPHP is a disease marked by kidney degeneration during childhood that leads to kidney failure requ...ed cell death as the mechanism underpinning kidney degeneration in NPHP. The genetic cause is a mutation in a gene called GLIS2. GLIS2 normally prevents cell deat...Time-lapse recordings reveal why IVF embryos are more likely to develop into twins
...er, our findings that collapse was associated with degeneration of blastocysts as well as the formation of the second ICM suggest that these episodes in which blastocoele volume cannot be maintained may be an artefact of culture. Furthermore, our findings suggest that the formation of two ICMs during blastocyst d...New genetic test developed at Emory advances detection and diagnosis of muscular dystrophy
...diseases characterized by progressive weakness and degeneration of the skeletal muscles that control movement. Some forms are seen in infancy or childhood, while others may not appear until middle age or later.Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy and primarily affects b...Early environmental exposure may accelerate age-related neurodegeneration
... common herbicide may contribute to the subsequent degeneration of brain cells associated with the onset of Parkinsons disease (PD), according to a new study in mice. The findings also showed that a compound that protects cells in the body from damage from certain forms of oxygen, a kind of antioxidant, could sup...Omega-3 fatty acids protect eyes against retinopathy, study finds
...the surface of the retina, and age-related macular degeneration (AMD), a disease of the macula, the part of the retina responsible for central vision, and a leading cause of vision loss in Americans 60 years of age and older. The researchers found that increasing omega-3 fatty acids and decreasing omega-6 fatt...JCI table of contents: June 21, 2007
...ters GLAST or EAAC1 have spontaneous optical nerve degeneration without elevated IOP. In GLAST-deficient mice, adm...werful system for further investigation of retinal degeneration in NTG and the development of therapies directed at preventing or treating IOP-independent glaucoma....UF researchers awaken vision cells in blind mice
...ery common types of blindness, age-related macular degeneration and diabetic retinopathy, if you can target cones you might be able to rescue that vision." Scientists experimented with mice with a form of hereditary blindness called achromatopsia, which affects about 1 in 30,000 Americans by disabling cone phot...Stowers Institute's Workman Lab demonstrates mechanism for decoding histone modification marks
...disease, which is marked by genetically programmed degeneration of neurons in certain areas of the brain. "The histone modification we focused on in this study, K36 methylation, is catalyzed by the human protein HYPB that interacts with the Huntington's disease protein known as huntingtin," said Dr. Workman. "O...Testosterone may help men with multiple sclerosis
...gel for men with MS reduced symptoms, slowed brain degeneration and increased muscle mass in men with relapsing-remitting multiple sclerosis, the most common form of the disease. Multiple sclerosis is a progressive disease involving the immune and central nervous systems. MS and many other autoimmune diseases ...Researchers identify new genetic risk factors for type 2 diabetes
...e activity of CDK5 in the pancreas may lead to the degeneration of beta cells. CDKN2A and CDKN2B. The proteins produced by these two genes inhibit the activity of cyclin-dependent protein kinases, including one that has been shown to influence the growth of beta cells in mice. Interestingly, these genes have ...U of M-led study identifies new genetic risk factors for type 2 diabetes
...e activity of CDK5 in the pancreas may lead to the degeneration of beta cells. CDKN2A and CDKN2B. The proteins produced by these two genes inhibit the activity of cyclin-dependent protein kinases, including one that has been shown to influence the growth of beta cells in mice. Interestingly, these genes have be...Stem cells provide new tool for studying disease and identifying ALS drugs
...ential new therapies aimed at slowing motor neuron degeneration in ALS. "That's what happens when scientists from major institutions work together toward shared goals. Project A.L.S. prides itself on building productive research teams from elegant parts," said Valerie Estess, director of research for Project A...Diseased brain cells more involved in ALS-associated motor neuron death
...onic stem cells. In ALS, there is a progressive degeneration of motor neurons, leading to paralysis and eventua...in the process thereby stalling or eliminating the degeneration of motor neurons and the onset of debilitating ALS symptoms. ......aling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy AUTHOR CONTACT: Denis C. Guttridge Ohio State University College of Medicine, Columbus, Ohio, USA. Phone: (614) 688-3137; Fax: (614) 688-4006; E-mail: denis.guttridge@osumc.edu . View the PDF of this article at: ...