Tag: "degeneration" at biology news

CSHL shows correcting RNA splicing may help treat spinal muscular atrophy

...odels. "SMA patients who suffer from motor-neuron degeneration may benefit from our ability to correct the mRNA splicing defect that makes their SMN2 genes only partially functional," suggested CSHL Professor Adrian Krainer, Ph.D. RNA splicing antisense technology allows researchers to influence the ultimate s...

Transport interrupted -- Texas A&M biologists trace cause of early blindness to tissue defect

...utations that lead to additional causes of retinal degeneration and blindness....

Researchers discover gene essencial to cerebellum formation

... cerebellar ataxias, which is characterized by the degeneration of Purkinje cells. Producing this type of cell in the lab may lead to future neuronal replacement therapy....

U-M team: Genetic testing sheds light on degenerative eye disease

...in which parents with no family history of retinal degeneration requested genetic testing in hopes of revealing the specific nature of their sons eye disease. They also wanted to know whether the younger son, who was experiencing more subtle symptoms, had the same disease or a milder vision problem due to a diffe...

Decision-making -- Demonstration of a link between cognition and execution

...kinson's disease, as this condition is caused by a degeneration of dopamine-producing neurons. As a result, it will be necessary to adopt a new approach to this disease. Although Parkinson's disease expresses itself through severely incapacitating motor disorders, such as an increasing difficulty in initiating ...

Sentry enzyme blocks two paths to Parkinson's disease

The degeneration of brain cells that occurs in Parkinson's disease may be caused by either externally provoked cell death or internally initiated suicide when the molecule that normally prevents these fatal alternatives is missing, according to studies in mouse model...

Prion disease treatable if caught early

...ce, Mallucci and colleagues found that early brain degeneration can be reversed if prions are depleted in neurons. In the new studies published in Neuron, they established that cognitive and behavioral impairmentswhich appear early in humans with prion diseasecan be reversed if prion depletion is done early. Wh...

Carbon monoxide protects mice from multiple sclerosis

...MS) is a chronic inflammatory disorder that causes degeneration of the nerves in the brain and spinal cord, leading to various symptoms including muscle weakness and pain. Most individuals with MS go through cycles of disease and remission, leading to the suggestion that there are regulatory mechanisms that count...

JCI table of contents: January 25, 2006

...MS) is a chronic inflammatory disorder that causes degeneration of the nerves in the brain and spinal cord, leading to various symptoms including muscle weakness and pain. Most individuals with MS go through cycles of disease and remission, leading to the suggestion that there are regulatory mechanisms that count...

News tips from the Journal of Neuroscience

...nd sizes. Charcot-Marie-Tooth type 2 (CMT2) causes degeneration of peripheral sensory and motor neurons, particularly at the ends of these long axons. Many cases of CMT2 arise from mutations in a mitochondrial fusion protein mitofusin 2 (MFN2). This week, Baloh et al. propose that MFN2 mutations cause disease by ...

Science's breakthrough of the year -- The Poincar Theorem

...e form of vision loss known as age-related macular degeneration showed that the drug ranibizumab improves vision in some patient and identifying several genes that influence a persons susceptibility to the disease. How Biodiversity Happens: From beach mice, to fruit flies, to butterflies, a variety of animals...

Study shows cats can succumb to feline Alzheimer's disease

...ats for their own benefit, so we can slow down the degeneration the disease brings and keep them as happy cats for as long as possible." "As with humans, the life expectancy of cats is increasing and with this longer life runs the greater chance of developing dementia. Recent studies suggest that 28% of pet ca...

Protein protects against nerve degeneration

A protein called NMNAT protects against nerve cell degeneration in fruit flies and mice, said Baylor College of Me...the neurons degenerated very rapidly. However, the degeneration could be slowed by keeping the flies in the dark and preventing their visual neurons from activating...

Gene linked to aggressive 'wet' age-related macular degeneration

...g the aggressive "wet" form of age-related macular degeneration (AMD), the most common cause of blindness in peopl...y" is more common than the "wet" form. Wet macular degeneration can rapidly lead to blindness, while the dry AMD progresses more slowly. Last year, Josephine Hoh,...

Transplanted photoreceptor precursor cells restore visual function in mice with retinal degeneration

...ed into three different types of mice with retinal degeneration caused by distinct genetic defects involving malfu...degenerative diseases, such as age-related macular degeneration and retinitis pigmentosa, it is the loss of photoreceptors that leads to blindness. Understandin...

New biologic treatment for tennis elbow may replace surgery for chronic sufferers

...ong gripping or repetitive wrist motions. It is a degeneration of the tendon above the elbow that controls the movements of the wrist and hand. Treatments such as rest, nonsteroidal anti-inflammatory drugs, bracing, physical therapy, and injections of corticosteroids (cortisone shots) are often used but recent ...

New gene linked to macular degeneration risk

...y increased risk of developing age related macular degeneration during their lifetime. "If anyone in your family has a history of macular degeneration, this test would be advised," says Dr. Zhang. "The addition of this new piece to the AMD puzzle suggests that this gene plays a critical role in the formation of...

Rush and UCSF found gene therapy appeared to reduce symptoms of Parkinson's by 40 percent

...he putamen is a region of the brain that undergoes degeneration and reduced dopamine production in Parkinson's disease patients and this has been closely linked to the major motor deficits in these patients. All patients entered in the trial were judged to have inadequate control of their disease with standard ...

News tips from the Journal of Neuroscience

...l. test the role of these serine proteases in axon degeneration in mice with progressive motor neuronopathy ( pmn/...uron disease starts in axon terminals, followed by degeneration of cell bodies, and is paralleled by increases in PA levels in sciatic nerves. The pmn/pmn animals s...

Burnham awarded $12.7 million from NIH to create one of nation's top neuroscience research centers

... team will be collaborating on studies of neuronal degeneration in human brains and animals models of Alzheimer's Disease, Parkinson's Disease, Prion Disease and other neurological conditions affecting the population." With more than 100 scientists involved in the research, projects will address a range of neuro...

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