Tag: "degeneration" at biology news
Gene therapy for inherited childhood blindness tested in mice
...tinal function to near-normal levels and prevented degeneration
in one type of retinal cell-the cones-until at least four months, an age at which almost all cones have degenerated in untreated Rpe65-deficient mice....
Can further studies lower the cost of preserving vision?
...egeneration, a complication of age-related macular degeneration
that leads to the vast majority of legal blindness...on. Only about 10 percent of patients with macular degeneration
develop neovascularization, but in those who do, the effects are often severe. While blocking blood ...
New angiogenesis finding may help fight cancer growth
...he more severe ("wet") form of age-related macular degeneration
(AMD). Wet AMD occurs when leaky blood vessels form in the retina. Along with a similar growth of new blood vessels in diabetes, it is the major cause of blindness in older adults. But the "holy grail" of angiogenesis inhibition concerns cancer tre...
News tips from the Journal of Neuroscience
...o disrupt receptor binding of soluble TNF, reduced degeneration
of rat dopaminergic neurons after intrastriatal in... provide a compelling link between soluble TNF and degeneration
of dopamine neurons....
Variation in 3 genes influences risk of age-related macular degeneration
...) gene that is associated with age-related macular degeneration
(AMD), the leading cause of irreversible visual impairment and blindness among persons aged 60 and older. Their analyses, for the first time, combine this new variant with all previously reported variants to estimate individual risk of advanced AMD. ...
News tips from the Journal of Neuroscience
... DRG neurons, then assayed their effects on axonal degeneration
2472 h following axotomy. Nmnat1 had the strongest protective effect. However, nicotinamide phosphoribosyl transferase (NmPRT) and nicotinic acid phosphoribosyl transferase (NaPRT), which convert the precursor molecules nicotinamide and nicotinic aci...
Role for macrophages in age-related macular degeneration
...se--may have a crucial role in age-related macular degeneration
(AMD). Rajendra Apte and colleagues from the Washi...ntly inhibited this process. Age-related macular degeneration
(AMD) is the leading cause of blindness in people over 50 y of age in at least three continents. CNV...
A humble aquarium fish may be the key to new therapies for birth defects
...ir disease, which, in its most severe form, causes degeneration
and death within two to three years after birth. "We found this mutation about two and a half years ago," said Solnica-Krezel. "Because it impairs so many aspects of normal development and causes the embryo to fall apart in two days, we named it 'C...
Study illuminates birth defects caused by copper deficiency
...port ATPase (ATP7A), leading to symptoms including degeneration
of parts of the brain and severe failure to thrive. Similarly, in a variety of mammals, copper deficiency during pregnancy results in loss of the embryo or offspring with severe neurologic impairment and developmental defects of the heart, skeleton, ...
$14.6 million NIH Grant will build on macular degeneration findings
...s into possible treatments for age-related macular degeneration
(AMD). The grant was awarded Aug. 1. Gregory Hageman, Ph.D., professor of ophthalmology and visual sciences at the University of Iowa Roy J. and Lucille A. Carver College of Medicine, will lead the multi-institutional effort. AMD is the most freq...
Discovery of agile molecular motors could aid in treating motor neuron diseases
...r's lab found that a mutation in dynactin leads to degeneration
of motor neurons, the hallmark of motor neuron dis...roteins in the cell, which may in turn lead to the degeneration
of the neuron. Scientists are now finding that many other molecular motors are remarkably flexible...
Friend or foe: Could a protein linked to Alzheimer's be related to vision loss in seniors?
...or does essentially nothing to the rate of retinal degeneration
in genetically altered mice that undergo progressive, age-dependent vision loss. Fliesler's team will selectively introduce either the human apoE-3 or apoE-4 gene into the mice and then study what effects this may have on the structure and function o...
Smoking increases risk and omega-3 fatty acids decreases risk of blinding disease
...n increased risk of developing age-related macular degeneration
as compared to those who never smoked. At the same time, those who ate more fish and had diets with higher levels of omega-3 fatty acids reduced their risk of this blinding disease. Their findings are published in the July 2006 issue of the Archives ...
New Down syndrome gene identified by Stanford/Packard scientists
...s is the first time it has been linked directly to degeneration
of a specific group of neurons in the brains of those with Down syndrome. The breakthrough confirms an idea suggested by previous research: Neuronal degradation in people with Down syndrome is the result of an interrupted conversation between nerve c...
Cause of neuronal death in Down's syndrome, Alzheimer's disease could be surprisingly simple
...und that the NGF transport disruption leads to the degeneration
of "basal forebrain cholinergic neurons" (BFCNs) i...overdose of APP might also play a role in neuronal degeneration
in Down's syndrome and thereby contribute to cognitive deficits in both Down's syndrome and Alzheime...
'Molecular assassin' targets disease gene
...n cancers and blindness due to age-related macular degeneration
(AMD) and diabetic retinopathy are likely to be among the first uses for the drug. AMD is the most common cause of blindness in Australia (Macular Degeneration Foundation). The experimental drug has already been shown to be effective on skin cancer...
New method for dating art prints and early books borrows know-how from genetic science
...ting books using predictable woodcut and engraving degeneration
constitutes one of those rare 'A Ha!' moments in bibliographical studies," comments David L. Gants, an expert on the physical characteristics of early books at the University of New Brunswick in Canada, who did not participate in the research. "If th...
Neurons grown from embryonic stem cells restore function in paralyzed rats
...shown that stem cells can halt spinal motor neuron degeneration
and restore function in animals with spinal cord injury or ALS. However, this study is the first to show that transplanted neurons can form functional connections with the adult mammalian nervous system, the researchers say. They used both electrophy...
Researchers find new clues to biochemistry of 'anti-aging'
...addition, elevated levels of sirtuins somehow slow degeneration
in nerve cells that have been damaged, and the enzymes affect aspects of metabolism responsible for controlling insulin secretion." Denu and his team, which has published widely on sirtuins, conducted test tube studies using mouse cells to learn exac...
Rare disease's gene may illuminate major disorders
...al dystrophies, could shed light on the nerve cell degeneration
that leads to such neurological maladies as Parkinson's and Alzheimer's diseases, both known to be associated with brain iron accumulation. "If you're a family with a kid with one of these diseases, the impact is clear, specific and personal," said S...
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