New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
...t can be found in the nervous system, resulting in degradation of brain and nerve tissue as is seen in patients with MS and GBS....Cancer related gene p53 not regulated as indicated by previous tissue culture research
...s that its DNA has been damaged, it slows down the degradation of p53, so that p53 protein levels can rise and in...s, of the p53 protein are crucial for both, timely degradation or activation. To explore the effects of these modifications in vivo, Salk scientists genetically e...UT Southwestern researchers discover master switch in cell death
...his is the first enzymatic step that regulates the degradation of proteins that control cell death." The beneficial side of cell death known as apoptosis occurs when it kills cells at appropriate times, as is the case, for example, when it removes the webbing from the fingers of an embryo or shapes a developin...Researchers merge spatial and temporal structure within a metapopulation model
...tation of native habitat. A consequence of ongoing degradation is that more and more species are being challenged to survive as spatially structured populations within patchy landscapes. The fate of these species depends in part on their perceptions of the spatial and temporal structure of the landscape: a speci...Heterochromatin assembly in S. pombe
...proteins and their subsequent proteasome-dependent degradation may control histone methylation and heterochromatin formation," explains Dr. Peterson....Fundamental discovery -- bone fracture
...re resistance that was previously unknown. Now the degradation mechanisms and deficiencies can be studied. "If you don't know something is important then you can't do anything about it. This is a fundamental and new discovery in an old and well-studied field," Hansma added. He noted that bone fracture is a ...New analysis services for the wine-producing sector
...corking process and barrels. These components, the degradation of which give rise to compounds which are attributed with the taste or the smell of being "corked" or "musty", is one of the most common defects in wine and most quickly detected by the consumer and, in many cases, the main cause of returns that are...New molecule may aid in production of biofuels and fungi-resistant plants
... discovery of a new molecule that is essential for degradation of the biopolymer chitin. This new molecule could ...al types of plague organisms and parasites, chitin degradation is of great interest to humanity. For example, insects might be combated by interfering with their c...Firefly protein lets researchers monitor molecule linked to cancer
...s enabled, IKK triggers reactions that lead to the degradation of IKB. In cells with genetically altered IKB, the attached luciferase is broken down too, meaning scientists can detect increased IKK activity via decreased light from the cells. "This is like doing in-vivo pharmacodynamics and pharmacokinetics," s...Hide and seek: Researchers discover a new way for infectious bacteria to enter cells
... outside surface of the cell and the recycling and degradation machineries are inside, the cell must bring Met inside through endocytosis in order to dispose of it. As the cell creates the vesicle that will transport tagged Met, Listeria stows away and invades the cell. By manipulating the gene expression of...Study identifies protein's role in cell division
...ystem, Upf1, is the same protein that triggers the degradation of histone messenger RNA, a normal cellular messag... link DNA damage at the site of replication to the degradation of histone messenger RNA," Marzluff said....JCI table of contents September 1, 2005
...ulate cytokine signaling by targeting proteins for degradation by the proteasome. In particular, the function for the SOCS-7 protein was previously unclear. In a study appearing online on August 25 in advance of print publication of the September 1 issue of the Journal of Clinical Investigation, Paul Rothman a...Insulin sensitivity gets a kick out of SOCS-7
...ulate cytokine signaling by targeting proteins for degradation by the proteasome. In particular, the function for the SOCS-7 protein was previously unclear. In a study appearing online on August 25 in advance of print publication of the September 1 issue of the Journal of Clinical Investigation, Paul Rothman a...In Iran, camera traps reveal rare Asiatic cheetahs
...the early years of the 1978 revolution, along with degradation of habitat due to livestock grazing, have pushed this important predator to the brink of extinction. Once known as "hunting leopards," cheetahs have played a significant historical role in Iranian culture being trained by its emperors to hunt gazell...Cancer drug target Chk1 may also be source of drug resistance
...responses that fight cancer while the simultaneous degradation of Chk1 can allow cancer cells to escape drug-induced death and resume progressive tumor growth. The study suggests the Chk1 protein is critical for ensuring the repair of mutations and other errors in DNA replication before they can alter the funct...Roadways and parking lots threaten freshwater quality in the northeastern US
...hey also come with a serious unforeseen cost-- the degradation of freshwater ecosystems. In a recent Proceedings of the National Academy of Sciences paper, Drs. Sujay S. Kaushal, Peter M. Groffman, and Gene E. Likens of the Institute of Ecosystem Studies, with colleagues, detail how roadways and deicers are com...Purdue scientists treat cancer with RNA nanotechnology
... needs to find better ways to protect the RNA from degradation by enzymes in the body. Although the group still needs to prove the safety of their tiny creations, Guo said, they remain confident that their work is a milestone for medical nanotechnology. The team has already obtained further results that could he...Experts develop global action plan to save amphibians facing extinction
...e susceptible to extinction due to habitat loss or degradation than most other vertebrates." The sharp decline in amphibian populations could be ominous for all life on the planet. Because they live on land and in water, and their porous skins absorb oxygen and water, amphibians could be the first group to feel ......argeting the origin recognition complex (ORC1) for degradation by the ubiquitin ligase, APC. The ORC destruction ...ay serve a more widespread role in the proteosomal degradation of various cell cycle factors in other eukaryotes, as well. This work reveals a heretofore unknown m...... a novel role for the ubiquitin/proteosome protein degradation pathway in the regulation of local actin dynamics ...tes the kinase LIMK1, targeting it for proteosomal degradation in the growth cones of hippocampal neurons. LIMK1 regulates the dynamics of the actin cytoskeleton ...