New Down syndrome gene identified by Stanford/Packard scientists
...s an idea suggested by previous research: Neuronal degradation in people with Down syndrome is the result of an interrupted conversation between nerve cells in a specific part of the brain. Like a classroom troublemaker, a signaling neuron needs feedback to thrive. It lobs specialized compounds called neurotr...Researchers get closer to preventing Alzheimer's disease
...nt results raise the possibility that a deficit in degradation of amyloid peptides from IDE could raise levels of toxic beta-amyloid peptides even before AD dementia is diagnosed. If these results are confirmed, Mount Sinai researchers suggest that boosting IDE activity pharmacologically may reverse beta-amyloid...Energy-rich portfolio of new genome sequencing targets for DOE JGI
...ortant enzymatic systems involved in oxidation and degradation of polyphenolic substances--pollutants that are targets for bioremediation. Actinobacteria, which can be found in soil, can be harnessed for environmental clean-up as well. Strains, the subject of another CSP project, proposed by researchers at ...Yale dean addresses biggest environmental threats in new book
..., ozone depletion, deforestation, desertification, degradation and shortages of freshwater, decline of marine fisheries, toxic pollutants and excess nitrogen -- all of which contribute to creating dead zones in the world's oceans. The book also tells how in recent decades nations, non-governmental organization...Early fetal gender test demands rapid ethical policymaking
...will just have to learn to live with the resulting degradation of the value of human life." Review Title: Baldwin, T: Understanding the opposition: Prenatal Diagnosis, DOI: 10.1002/pd.1473 Will easier access to more effective sex selection affect gender balance? Probably not .. Increasing ease of trave...SNM honors outstanding contributors
...h interests include correction for causes of image degradation in nuclear medicine such as attenuation, distance-dependent spatial-resolution and scatter; tomographic image reconstruction for SPECT and PET; assessment of image quality by task performance studies using human and numerical observers; quantization ...Alternative approaches to marine management prove successful in reef conservation
...conservation and community goals and reversing the degradation of reef ecosystems. ...UT Southwestern scientist named Keck Foundation Distinguished Young Scholar in Medical Research
...own in detail how the enzyme is targeted for rapid degradation when certain sterols build up in cells, thereby stopping cholesterol synthesis. His work is conceptually brilliant, technically courageous and medically relevant. His selection as a Keck Scholar is eminently justified." The W.M. Keck Foundation es...Marine protected areas: it takes a village, study says
...conservation and community goals and reversing the degradation of reef ecosystems. Other authors of the study include Michael J. Marnane of the Wildlife Conservation Society; Joshua E. Cinner of the Centre of Excellence for Coral Reef Studies, James Cook University in Townsville, Australia; and William Kiene of...JCI table of contents: July 27, 2006
...s were observed. It was previously known that bone degradation by osteoclasts stimulated new bone formation by osteoblasts. The results of the current study indicate that it is the GC-induced delay in the death of osteoclasts that dampens osteoblast activity and as such retards new bone formation, resulting in G...Small-scale logging leads to clear-cutting in Brazilian Amazon
... Amazon rain forest. First they showed that forest degradation by loggers affects as much forest as clear-cutting for cattle ranching and swidden agriculture. This latest article demonstrates that these two processes are intimately linked--that the thinning begets forest replacement by cattle pastures and swidde...HIV's cellular kiss of death explains loss of uninfected T cells in AIDS
...ent by the HIV envelope glycoprotein activates the degradation pathway known as autophagy, causing the death of these uninfected "bystander" cells. The authors go on to show that molecules known as "short interfering RNAs" specific for two different genes involved in the autophagy pathway (beclin1 and atg7) can ...Marijuana use causes early pregnancy failure
...the enzyme NAPE-PLD is carefully balanced with its degradation by the enzyme FAAH, resulting in a finely tuned local "anandamide tone" in embryos and the oviduct. This balance is required for normal embryonic development, transport along the oviduct, implantation in the uterus, and full-term pregnancy. In the ...JCI table of contents: August 1, 2006
...the enzyme NAPE-PLD is carefully balanced with its degradation by the enzyme FAAH, resulting in a finely tuned lo...ent by the HIV envelope glycoprotein activates the degradation pathway known as autophagy, causing the death of these uninfected "bystander" cells. The authors go ...Study reveals how cells destroy faulty proteins in cystic fibrosis
...arolina at Chapel Hill scientists. Turning off the degradation system allows some proteins to regain their proper...nize misshaped regions of CFTR and tag them with a degradation signal known as ubiquitin. The ubiquitin tag tells the cell to destroy the marked CFTR, a process ov...Brain enzyme treatment relieves memory lapse in Alzheimer's mice
...ed proteins, suggesting some defect of the protein degradation machinery, the researchers noted. Studies of the brains of humans with Alzheimer's after death found evidence that the proteasome remained intact but largely unable to degrade proteins. Interestingly, Uch-L1--a protein found almost exclusively in n...Remote island provides clues on population growth, environmental degradation
...y in terms of expanding populations, environmental degradation and increasing warfare. Rapa is a little microcosm of our planet. There are lessons about the consequences of population growth to be learned there." ...Research partnership to protect the Coorong
... way," Dr Geddes said. "There's serious ecological degradation and hypersalinity is threatening various species o...t initiatives are underway to halt and reverse the degradation of the Coorong, such as the Murray-Darling Basin Commission's "Living Murray Initiative". However, p...UA strengthens commitment to Arctic research
...arine Research in Potsdam, Germany Research: The degradation of permafrost in the arctic due to climate change, using remote sensing, spatial data analysis and other methods Principal: Vladimir Romanovsky, Geophysical Institute Who: Jzsef Geml, plant pathology and molecular evolutionary genetics, Pennsy...Drug combo may reduce protease inhibitor-related hardening of the arteries
...itor-induced atherosclerosis by ubiquitination and degradation of protein kinase C," was carried out by Emily L. Bradshaw, Xian-An Li, Theresa Guerin, William V. Everson, Melinda E. Wilson, Annadora J. Bruce-Keller, Richard N. Greenberg, Ling Guo, Stuart A. Ross and Eric J. Smart. The researchers are from the Un...