Untangling a pathology of Alzheimer's
... PSA does directly act on tau to snip it apart for degradation by the cell. They next compared levels of PSA gen...enriched, to our knowledge, its role vis-a-vis tau degradation or modification of tau-induced neurodegeneration has not been characterized previously. "Data deriv...OHSU lab links gene to aged skin problems, cancer
... cancer. "Our study identifies a new Beta-catenin degradation pathway," the scientists said in the study. "This ...ese diseases, blocking Smad7-mediated Beta-catenin degradation may offer a therapeutic approach....Biomarkers of response to VEGF pathway-targeted therapy discovered for renal cell carcinoma
...HL gene, Jaeger said. The mutations prevent proper degradation of specific VHL target proteins, which leads to over-expression of VEGF and other proteins associated with angiogenesis, he said. These proteins cause the tumor to become highly vascular, establishing a solid blood supply to feed the cancer. When fun...USGS at The Wildlife Society: From sea-ice change to contaminants to predators and prey
... contaminants, international treaties, and sea ice degradation from climate change. While telemetry data can desc...e of polar bears to those characteristics. Sea-ice degradation due to climate warming will have the largest future impact on polar bears and their prey. RSFs emplo...New wood-plastic composites to boost industry, help use waste products
...temperature of the plastic is higher than the wood degradation temperature. With this approach, the new wood-plastic composites can use very inexpensive plastics such as those found in old carpet fibers about 4.4 billion pounds of which are now wasted every year, going into landfills where they are extremely sl...Sequencing of the oyster mushroom genome
...st important store of carbon in the Biosphere. The degradation of this compound is an essential step in the transformation of cellulose - the principal store for carbon into biofuel. Moreover, it has to be taken into account that lignin has a chemical composition that is not easy to break down similar to som...ACS News Service Weekly PressPac -- Oct. 4, 2006
...cetylcholine levels by preventing neurotransmitter degradation and reeducating amyloid beta aggregation, thereby simultaneously treating both the symptoms and progression of Alzheimer's disease." ARTICLE #1 FOR IMMEDIATE RELEASE "A Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease...Patchwork strategies may be best for restoring Texas rangelands
...ary reason for woody plantencroachment, ecological degradation and loss of plant diversity. "Rangeland restoration has traditionally been based on chemical,mechanical and/or fire techniques applied to an entire pasture atinfrequent intervals," he said. "These large-scale disturbances havegenerally created la...Possible evidence of cell division, differentiation found in oldest known embryo fossils
...esearchers felt confident excluding such causes as degradation in the carefully selected sample they were studying. They believe the uneven cell division is a developmental control and is possible evidence "that sophisticated mechanisms for differential cell division timing and embryonic cell lineage differentia...JCI table of contents: Oct. 12, 2006
...r (TRbeta), which binds thyroid hormone (T3). This degradation allows chromosome separation to proceed during anaphase. However, in a mouse model of thyroid cancer a mutant form of TRbeta, which is unable to bind T3, failed to trigger PTTG1 degradation, resulting in elevated PTTG1 protein levels. This caused abn...Open Science Conference to focus on regional sustainability challenges to the Earth system
...demand for food will lead to further environmental degradation which may, in turn, further undermine the food systems upon which food security is based. ESSP research aims to determine strategies to cope with the impacts of global environmental change on food systems and to assess the environmental and socioecon...USGS at Society of Environmental Toxicology and Chemistry
...es and their degradates, environmental occurrence, degradation pathways, modes of action, and toxicity to aquatic organisms. For more information, contact Kathryn Kuivila at kkuivila@usgs.gov or 916-278-3054. The symposium, which is sponsored by the U.S. Geological Survey and Mississippi State Chemical Laborat...An AIDS-related virus tricks cells to become tumors, new Penn study finds
...t the garbage for disposal. Ubiquitylation and degradation involve a complex set of proteins in addition to u...cell, p53 and VHL themselves would be targeted for degradation and HIF-1a would then be free to activate genes involved in growth of blood vessels to increase the ...Small, smaller, smallest -- The plight of the vaquita
...ds extinction" It is not, as is so often the case, degradation of its habitat. A risk factor analysis discounted pollution or the drastic reduction of freshwater flow from the Colorado River as primary culprits. It is also not a genetic problem. Genetic analyses and population simulations suggested that the vaqu...Extreme life, marine style highlights 2006 ocean census
...f seagrass and wetland habitat, a 10 to 1,000-fold degradation of water quality, and accelerated species invasion...happily, they also found signs of transitions from degradation to recovery where conservation was implemented during the 20th century. Scarce in time An expediti...MIT creates 3-D scaffold for growing stem cells
...D microenvironment, but concerns exist about their degradation products and chemicals," the authors wrote in the paper. Other synthetic polymer biomaterials are simply too big. Getting cells to grow on them is like forcing spiders to build webs on skyscraper girders. Zhang's nanofiber scaffold, around 1,000 tim...Novel regulation of the common tumor suppressor PTEN
...adding a molecular tag, ubiquitin, to PTEN causing degradation in the cellular machinery called proteasome. In a ...N into the cell nucleus where it is protected from degradation and cancer is initiated. According to the researchers, the uncovered key role of PTEN degradation p...Gene that makes people 'early to bed and early to rise' demystified
...production of less PER2, while the clock protein's degradation remains unaffected," they explained. Thus, the researchers added, "PER2 levels are lower at all time points and, in the latter half of a cycle, fall below the threshold earlier than normal, leading to activation of transcription earlier and resulting...Getting one's protein in a bunch -- When quality control fails in cells
...ain amount of mutant proteins, and use a series of degradation and recycling steps to get rid of them," said Michael Ibba, the study's lead author and an associate professor of microbiology at Ohio State University. "But sometimes the cell produces more mutations than it can handle. That buildup can overwhelm ...Cypress replanting unsuccessful without dual cultivation with lavender or mycorrhizal fungi
...cies contributes to efforts to control erosion and degradation of forest soils. But it is highly sought after by local communities particularly for the quality of its wood. In addition, the young shoots are subjected to overgrazing (by sheep) which hinders the species' natural regeneration. Replanting operations...