Mice thrive despite massive genetic makeover
...sing sequences contained important genes and their deletion had severe consequences for the animal. The other authors of the study include Yiwen Zhu, Ingrid Plajzer-Frick, and Veena Afzal. ...Study identifies molecular complex vital to creation of miRNAs
...orge syndrome, the most common disorder of genetic deletion in humans. A swathe of DNA containing multiple genes is missing in DiGeorge syndrome patients, and many are born with heart defects, immune deficiencies, and developmental and behavioral problems. Intriguingly, one in four also goes on to develop sch...JCI table of contents, December 15 2004
...em nuclei, the condition results from mutations or deletion of the SMN1 gene. In the December 15 issue of the Journal of Clinical Investigation , Mimoun Azzouz and colleagues from Oxford BioMedica report that multiple single injections of a lentivector expressing human SMN into various muscle of mice with sp...MIT creates new model of cancer syndrome
...sted in the mouse. These mutations do not lead to deletion of p53, but have more subtle effects. The authors found that mice that possessed either of the two mutations in p53 developed more tumors and more different types of tumors than do mice completely lacking p53. "By knocking out p53, the mice di...Research identifies promising route for treating age-related hearing loss
Researchers have discovered that deletion of a specific gene permits the proliferation of ne...ir cells," said Corey. "So Zheng-Yi has found that deletion of this gene can allow functioning hair cells to continue to divide. They are no longer limited by w...Pro-inflammatory enzyme linked to diabetes; Immune system's macrophages may be key to treatment
...his study, because a previous study has shown that deletion of Ikk- in muscle has no effect on obesity-induced insulin resistance and type II diabetes, although muscle is a major insulin-responsive tissue....Opposing fat metabolism pathways triggered by a single gene
...t content in the larvae. They further showed that deletion of nhr-49 changed expression of 13 genes related to fat and glucose metabolism, with the most dramatic effects occurring within two metabolic pathways: mitochondrial lipid oxidation and fatty acid desaturation. Following up on these changes in ge...JCI Table of Contents, March 1, 2005
...nhibitor or placebo for a week after MI. Targeted deletion of MMP-2 gene or drug-induced inhibition of MMP-2 ...risk of cardiac rupture after MI. TITLE: Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice ...Duke researchers uncover genetic link to kidney damage after heart surgery
...de synthase 849T and angiotensin converting enzyme deletion allele had a 162.5 percent increase in creatinine in the blood. This translates into a 60 percent reduction in the kidney's filtering ability, a rate more than twice as high as the study population as a whole. "If this vulnerability is borne out in ...Linking brain to mind in a common genetic disease
...ed the studies of children with chromosome 22q11.2 deletion syndrome, the most common genetic deletion syndrome. In this disorder, a tiny portion of chromosome 22 is missing, causing symptoms such as hea...New tumor-suppressor gene discovered
...ging lots of material along with it. "With such a deletion of material, this gene is basically gone, so we knew it couldn't possibly function at all," Lai says. Both kinds of mutations resulted in the formation of the same kinds of tumors. These studies indicate that the disabling of this one gene alone ca...Institute for Medical Research scientists identify gene critical to type 1 diabetes
...mune system messengers through this method of gene deletion and none were found to play a role in the development of the disease. Type 1 diabetes afflicts approximately one million people in the United States and studies show that it is on the rise worldwide. The disease is caused by an inability of the body ...Chemists identify key gene in development of type 1 diabetes
...treatments, prompted us to examine the role of MIF deletion in the disease process. In contrast to wild-type m...treatments, prompted us to examine the role of MIF deletion in the disease process. MIF knockout mice were successfully produced in 1999. To confirm the critica...Emory scientists find new prostate cancer suppressor gene
...f growth control in prostate cancer. Because gene deletion in chromosome 16 is common in many types of cancer, including lung, head and neck, nasopharynx, stomach, breast, and ovary, ATBF1 could be involved in the development of these cancers as well."...JCI table of contents April 1, 2005
...s have generated three types of mice with specific deletion of IRS2 expression. One line has reduced IRS2 in insulin-producing cells of the pancreas and the hypothalamus of the brain, one line has IRS2 reduced in all neurons and the last line has reduced IRS2 in a particular subset of neurons that regulate f...Thumbnail sampler of 10 diverse physiology papers from IUPS 2005
...reased atherosclerosis. To test if this was due to deletion of PKC beta they tested an inhibitor of this enzyme. The fed ApoE null mice with chow containing the PCK beta inhibitor ruboxistaurin, or vehicle chow. Compared to mice receiving vehicle chows, mice fed ruboxistaurin displayed significantly decreased...Chronic inflammation caused by too little stomach acid leads to gastric cancer
... is a stomach-specific tumor suppressor gene whose deletion in mice has been shown to result in gastric cancer," Zavros explains. "TFF1 appears to have a protective effect on the gastric mucosa. STAT3 is a gene that mediates inflammatory signals and has been linked to the development of cancer. "We are especi...Of mice and men's (and women's) contraceptives
...lled somatic cells. "There are many proteins whose deletion will cause male infertility, and others for creating female infertility, but not many that will lead to both male and female infertility without affecting the somatic cells." Animals deficient in the protein called MSY2 are infertile, but are other......lthy, apparently suffering no ill-effects from the deletion of the receptor, even when the fat content of their diet was raised substantially. In contrast, normal mice on a high-fat diet displayed typical symptoms of the first stage of diabetes. But strikingly, in the animals with extra GPR40 receptors, the d....... A new study suggests that detecting this genetic deletion during the initial evaluation of children with neu...are aggressive without having amplified MYCN. "The deletion of genetic material on chromosome 11 may account for a significant percentage of these high-risk neu...