NYU algorithm enhances ability to detect cancer genes
...cutive probes, and the score reflects how well the deletion of that genomic interval may explain the cancer in these patients. In other words, the computed score measures how likely it is for a particular genomic interval to be a tumor suppressor gene implicated in the disease. In order to validate their algo...Non-coding RNAs help silence the mammalian transcription
...ader-Willi and Angelman syndromes, result from the deletion of the identical portion of chromosome 15. Imprinting determines which disorder arises: When the deletion involves the chromosome 15 that came from the father, the child has Prader-Willi syndrome, but when ...JCI table of contents, May 18, 2006
...ory arthritis. The authors used a conditional gene deletion strategy to delete SOCS-3 only in hematopoietic an...checked viral persistence. Brooks et al. show that deletion of immunodominant T cells and functional inactivation can be prevented in vivo in mice during persis...Speeding the search for elusive chromosomal errors
...ems. For example, patients with chromosome 22q11.2 deletion syndrome may have heart defects, impaired immunity and developmental delay. Deletions of several genes in Prader-Willi syndrome may cause obesity and mental retardation. To seek out miniscule rearrangements in chromosomes, the Children's Hospital tea...New clues for treatment of liver cancer
...to occur in human liver and other cancers (namely, deletion of the p53 gene and activation of the Myc gene). A third genetic modification (the insertion of a gene that encodes a fluorescent marker protein) enabled the researchers to visualize the transplanted cells, and their descendants, in the adult mice. ...Chromosomal tests can determine brain tumor therapy, outcomes, Jefferson oncologists find
...rmed in a multicenter trial that the 1p and/or 19q deletion was highly predictive and prognostic of patient ou...are now categorizing them according to chromosomal deletion status." "That's actually more predictive than what they look like under the microscope," Dr. Cur...News tips from the Journal of Neuroscience
... and the coactivators CLIM1 and CLIM2. Conditional deletion of lmo4 in the forebrain disrupted segregation of thalamocortical afferents into barrel domains in the somatosensory cortex. 3. An Approach to the Complexity of Neural Circuits Jonathon Shlens, Greg D. Field, Jeffrey L. Gauthier, Matthew I. G...Emory scientists develop new map of genetic variation in human genome
...sequence, and INDELs result from the insertion and deletion of small pieces of DNA of varying sizes and types....fibrosis is frequently caused by a three-base-pair deletion in the CFTR gene, and DNA insertions called triplet repeat expansions are implicated in fragile X sy...University of Washington researchers discover novel genomic disorders
...netics. One form of retardation, caused by a large deletion that spans six genes on chromosome 17, has charact...s were able to pinpoint the region of the specific deletion using NimbleGen's high-resolution CGH microarrays. "The ability of NimbleGen to rapidly generate cu...JCI table of contents: August 24, 2006
...of sudden death when they exercise. TITLE: Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia AUTHOR CONTACT:Bjrn C. KnollmanVanderbilt University Medical Center, Nashville, Tennessee, USA.Phone: (615) 343-6493; F...Mature muscle fibers can revert to become cancerous, researchers find
...e cancer by knocking them out, then seeing if that deletion blocks the creation of the cancer. "We can test virtually every gene in the fly genome," Dr. Galindo said. "There has been little progress toward developing effective therapies for rhabdomyosarcoma, in part because of the lack of animal models for ...'Protecting virus' offers instant flu protection and converts flu infections into their own vaccines
...protecting influenza virus has a huge but specific deletion of around 80% of the RNA of one of these 8 strands. This deletion makes the virus harmless and prevents it from reproducing by itself within a cell, so that it cannot...Hopkins researchers uncover critical player in cell communication
...in roughly one in 25,000 births and is caused by a deletion of a small section of chromosome 7 that contains several genes, including the gene that encodes the TFII-I protein. The discovery came after Desiderio and his team used biochemical "bait" to fish for candidate proteins that physically bind to TFII-I...JCI table of contents: Oct. 5, 2006
...opment Disorders that result from duplication or deletion of large regions of DNA are known as genomic disorders and are relatively common, ~1 per 1,000 births. Each disorder is characterized by a distinct set of neurobehavioral traits. For example, dup(17)(p11.2p11.2) is characterized by, among other thing...USC groups present at Neuroscience 2006
...ealthier. "These results indicate that myostatin deletion can slow weight loss, muscle wasting and motoneuron death as well as improve motor performance and life span [females only]," the study concluded. Anti-myostatin therapy also may help human ALS patients, Ko suggested. "At the very least, it can ...Genes offer researchers a 'crystal ball' to help them prevent, diagnose and treat cancer
...n"). They found that TMPRSS2-ERG fusion through deletion was more common in the tumor samples as compared to TMPRSS2-ERG fusion through translocation. More recent work has found a significant association between TMPRSS2-ERG fusion and death from prostate cancer, although the researchers have not yet been a...'Diabetes gene' may be linked to polycystic ovary syndrome
...ne CAPN10 UCSNP-19, which contains an insertion or deletion variation in the DNA sequence), -110, -58, -63, and -22. The researchers extracted these eight specific single-nucleotide polymorphisms (SNPs) V the small genetic variations that can occur within a person's DNA sequence because they are known to b...After 2 years, study shows Revlimid patients live longer and remain transfusion free
...ata showed that in MDS patients with chromosome 5q deletion treatment with Revlimid can provide long-term dura...all signs of the cancers genetic cause, on partial deletion of chromosome 5, and as a consequence reduce or even eliminate the need for transfusions in many pat...UCSF stem cell study reveals cells' capability in mouse brain tissue repair
... in the culture dish. In this sense, he says, "the deletion of Numb and Numblike was a test case." In collaboration with other UCSF neuroscientists, as well as neurosurgeons, Kuo is currently exploring whether neural stem cells of the SVZ can respond to damage outside the ventricle region and, if so, whethe......ncer. Galina Gusarova and colleagues showed that deletion of the mouse gene encoding FoxM1 after tumors had formed but while tumors were still growing, caused a substantial decrease in the number of tumors in the liver. A similar decrease was observed when mice with pre-existing tumors were treated with a c...