Profiling of cancer genes may lead to better and earlier detection
...h a mutation in the gene's DNA sequence or through deletion of the gene. Loss of tumor suppression function also can occur in a process called methylation, where a chemical called a methyl group is attached to a DNA region near the gene and prevents it from being activated, essentially "silencing" the gene. ...Beyond nature vs. nurture: Williams syndrome across cultures
...f chromosome seven, catapulting the carrier of the deletion into a world where people make much more sense than objects do. Despite a myriad health problems and a generally low IQ, children with Williams syndrome are loquacious, sociable, and irresistibly drawn to strangers. To determine the extent to which...Scripps Research study reveals new function of protein kinase pathway in tumor suppression
...al for ras-induced senescence in vivo, and whether deletion of the PRAK gene would make a difference in the ras-induced tumor-development process in PRAK knockout mice. A group of these mice and a group of normal mice were treated with DMBA, an environmental pollutant found in cigarette smoke and gas emission...Gene knockouts reveal FoxOs' vital functions in cancer defense, health of stem cells
...g deeper into the issue. Unexpectedly, however, deletion of FoxO1, 03, and 04 caused blood cell abnormalities but not outright leukemia. A bigger surprise was that the blood stem cells "were really in trouble without those transcription factors," he said, dividing too rapidly, losing their ability to renew...... affecting gene activity is where the variant is a deletion of a gene or part of a gene, we found examples where activity is affected from a distance," commented Barbara Stranger, first author and post-doctoral fellow at the Wellcome Trust Sanger Institute. "This may occur when the CNV reduces the effectivene...Cold Spring Harbor Laboratory scientists discover new gene that prevents multiple types of cancer
...ence the future of cancer research. It shows that deletion of a part of 1p36 causes cancer and increased "dos...ma, a specific form of brain tumor, frequently had deletion of CHD5, demonstrating the important role of CHD5 in human cancer. This research and discovery wa...Shedding new light on proteorhodopsin
...nipulate microbial genomes through the addition or deletion of key genes. ...Largest genomic search finds genes that may contribute to autism
...'t know what happens when there is an insertion or deletion of this genetic material," he added. Scientists believe that there may be five or six major genes and perhaps as many as 30 other genes involved in autism. Inheriting more of these genes or certain ones is thought to increase a child's likelihood...Largest-ever search for autism genes reveals new clues
...somal locations in affected individuals, including deletion of a neurexin gene. These anomalies can also make it more difficult to detect the genes that more commonly account for autism risk, say the researchers. Since each major autism candidate gene likely contributes to risk for a relatively small perc...Fetal heart-cell enzyme important in onset of heart failure
...treatment with chemical HDAC inhibitors or genetic deletion of HDAC2 prevented the beginning of the downward slide to progressive heart failure," says Epstein. HDAC is an enzyme switch that regulates how DNA is packaged inside the cell, and therefore how large groups of related genes are turned on and off. D...Blood sugar's manufacture limited by building blocks' supply
... The researchers found that mice with a targeted deletion of KLF15 display severe hypoglycemia after an overnight fast. They further found evidence that defective amino acid breakdown promotes the development of fasting hypoglycemia in the mutant animals by limiting the availability of a glucose substrate c...Researchers learn more about genetic mutation linked to autism
..., the mutation is a germline mosaic -- meaning the deletion occurred only in the father's sperm cells when he himself was in gestation. As result, the father did not have autism, but his two children, both daughters, inherited from him a chromosome that was missing a small piece of DNA that contained neurexin...News tips from the Journal of Neuroscience
...ribe a new mouse model of TSC based on conditional deletion of Tsc1 in neurons. Neurons ceased to express TSC1 around embryonic day 13. Developmental delays were apparent by postnatal day 5 and, unlike other TSC mouse models, the mice developed spontaneous seizures. Pathological features of TSC, such as enl...JCI table of contents: May 24, 2007
...nd colleagues found that mice with a targeted Gas1 deletion had underdeveloped faces, fused teeth, cleft palates, and severe ear defects, however their forebrains remained intact. These effects were associated with a partial loss of Shh signaling, suggesting that Gas1 is involved in Shh signaling in the early...News tips from the Journal of Neuroscience
...ve dimers with HIF-1. Mutant mice with conditional deletion of HIF-1 in forebrain neurons fared worse than wild-type (WT) mice after focal cerebral ischemia. WT mice that received pharmacological activators of HIF-1 showed further improvements. HIF-1 in neurons is not the whole story of neuroprotection, howev...... 18 percent longer lifespan, and the near complete deletion of brain Irs2 had a similar effect. Whats more, the animals lived longer, even though they had characteristics that should shorten their livessuch as being overweight and having higher insulin levels in the blood, said White. However, both sets o...