JCI table of contents: Nov. 1, 2006
... PICK: Decreased TGF-beta signaling might make you demented The physical changes that occur in the brain of patients with Alzheimer's disease (AD), the most common cause of dementia in the elderly, have been well characterized, but the cause(s) of this disease and the development of therapies has remained e...Attacks of King George III's madness linked to key metabolism molecule
...anation for the episodic attacks of irrational and demented behavior in porphyria, the disease believed to have afflicted "Mad" King George III, the British ruler blamed for the loss of the American colonies in the Revolutionary War. The mental and physical symptoms of porphyria, a rare genetic blood disease ...Alzheimer's disease linked to inflammation
... can hurtis if we start blaming the people who are demented for not exercisingtheir brains enough, or overselling activities that could make adifference where it's really unsubstantiated. I think we have got to bereal careful in our messages about risk reduction."...Early life stress harms mental function and immune system in later years
...cation have been found in the early-life stressed, demented rats, it may be feasible to find the specific molecules involved and design medicines to prevent the deficits," Baram says. In other work, researchers showed in rats that stress during the last third of pregnancy affects the ability of adult of...