US researchers show cottonseed drug is cancer treatment booster
...e University'sComprehensive Cancer Center, has now demonstrated that a potential small molecule inhibitor of Bcl-2/xL proteins can boost the efficacy of radiotherapy and chemotherapy. They showed that the molecule, (-)-gossypol (minus gossypol)[2], inhibited the anti-apoptotic function of Bcl-2/xL in cells, and i...Commandeering cellular machinery: recognition mechanism to detect small molecules
...o regulate metabolism in cells, Doyle said. Having demonstrated the ability to re-engineer one nuclear receptor to respond to a small molecule to which it previously did not bind, the research team next wants to demonstrate that the technique could apply to other small molecules. "Now we have to see how far we ca...How roots control plant shoots
...essary, she adds. In the study, she and Van Norman demonstrated that BPS1 could be manipulated to change the way l..., the biologists discovered the BPS1 gene and then demonstrated that it is required to prevent a plant from constantly producing the carotenoid byproduct that turns...Talented sniffer: A receptor known for guiding sperm to egg plays a role in the nose
...by using a number of experimental approaches. They demonstrated the expression of hOR17-4 in the human nose by usi...dard molecular techniques, whereas they tested and demonstrated the actual function of the receptor in a simple "sniffing test" as well as with electrical recording...Research team develops nonhuman primate model of smallpox infection
...ther virus by the intravenous route alone. Having demonstrated that it was possible to achieve lethal infection of primates using variola virus, the team next tried to determine whether lower doses of virus would produce a less accelerated disease course. In order to more closely mimic human smallpox, the animal...Is Interleukin-6 the 'holy grail' of exercise mediation?
...ntracting muscles and released into the blood, and demonstrated that IL-6 has many biologic roles, including: Activation/inhibition of metabolic genes Induction of lipolysis, or the breakdown of fat Inhibition of insulin resistance, and Suppression of tumor necrosis factor (TNF) production. In fact, Peder...Muscle-building hand-grips aid systolic blood pressure, carotid AD, endothelial function
...h-tech version of the muscle crowd's hand-grip has demonstrated the ability to lower blood pressure, improve the flexibility of the carotid artery and heighten vasoactive sensitivity in people taking medication for hypertension. Two studies at the McMaster University Department of Kinesiology Exercise and Metabol...Obese women with early-stage breast cancer more likely to die than women of normal weight
...ery (lumpectomy) and radiation therapy. "We have demonstrated a significant association between obesity and adverse breast cancer outcome in patients with early-stage breast cancer," explained Penny Anderson, M.D., a radiation oncologist at Fox Chase and lead investigator of the study. "Despite being diagnosed...HHS awards $232 million in biodefense contracts for vaccine development
...in human cells. Previous NIAID research has demonstrated that MVA is nearly as effective as the standard smallpox vaccine, making it a promising candidate for use in children and pregnant women as well as people with weakened immune systems or skin conditions such as eczema. The new contracts will allow th...Embryonic stem cells correct congenital heart defect in mouse embryos
...." In previous studies, Dr. Benezra and colleagues demonstrated a relationship between the presence of a specific ...cated in heart development and cancer. The authors demonstrated that IGF-I injected into the mother can cross the placenta and influence fetal cardiac development i...Cooperation to create a new tuberculosis vaccine
...e stimulated. In other fields, MOLOGEN has already demonstrated that its DNA vaccines stimulate the cellular immune response against infectious agents much more efficiently than other current vaccines. MOLOGEN CEO Prof. Burghardt Wittig states: "From the successful results obtained with our DNA vaccines against t...Cells in retina found to behave like soap bubbles
.... Now two Northwestern University scientists have demonstrated that the tendency to minimize surface area is not limited to soap bubbles but extends to living things as well. In a paper published Oct. 7 in the journal Nature , they show that cells within the retina take on shapes and pack together like soap bub...Support groups aid women with 'breast cancer gene mutations'
...nting the disease. Previous needs assessments have demonstrated that women affected by the genetic mutations are seeking support networks and therapy when no validated model currently exists. In the first prospective study to evaluate the effects of a psychosocial intervention for women carrying BRCA1 or 2 mutati...Estrogen protects male rats from aortic aneurysms
... abdominal aortic aneurysms. "Earlier studies have demonstrated that increased estrogen systemically inhibits the development of AAAs," Upchurch says. "Dr. Woodrum's study extends earlier research and suggests that there also is something inherent in males that increases MMP-9 and may lead to greater AAA formatio...Technique for genetically modifying blood stem cells brings cure for blood diseases closer
...ns. However, Persons and his colleagues previously demonstrated (Blood. 2003;102:506-513) a potential technique for enriching the relatively small population of HSCs modified by vectors. "This combination of using a more effective vector and enriching the population of HSCs that are genetically mo...New Jersey Institute of Technology environmentalist receives Fulbright Chair award
... or professional achievement and because they have demonstrated extraordinary leadership potential in their fields. Among thousands of prominent U.S. Fulbright Scholar alumni are Milton Friedman, Nobel Laureate in Economics, James Watson, co-discoverer of the structure of DNA and Nobel Laureate in Medicine; Rita...The CF Foundation urges all states to include newborn screening for cystic fibrosis in test panels
...ducted and gathered over the past two decades have demonstrated the benefits of newborn screening for CF. People with CF who are diagnosed at birth gain more weight and have better nutrition than those who are diagnosed later in life. Better nutrition and weight gain in children with CF has been linked to a slowe...Researchers find protein that makes long-term memory possible
...TP even when protein synthesis is inhibited. This demonstrated that mBDNF was essential for memory formation, and mBDNF is the newly-synthesized protein that scientists have been looking for that underlies L-LTP and long-term memory. In the next series of experiments, the NICHD researchers tested hippocampal...Using fruitflies to examine alcohol tolerance
... was not studied here." All three types have been demonstrated in humans, he added. "If researchers could develop an assay for acute functional tolerance in flies, they would then have a complete set of behavioral assays in parallel to those who work with rodents," said Crabbe. "Then, given the spectacular powe......l in forming the wings of a fruit fly. The Lin lab demonstrated that Dpp morphogen molecules are mainly distributed on the cell surface, which suggests that Dpp morphogen moves by an extracellular diffusion mechanism. To prove this hypothesis, Lin and colleagues blocked cell endocytosis and examined Dpp m...