As the protein folds: The tail of the gene tells the tale of Machado-Joseph disease
...ffects of the bad one. Their studies surprisingly demonstrated that the protective function of the ataxin-3 protein does not rely on the multiple repeats in its tail but in a region near the head. Indeed, it seems that removing or altering this region of the gene can accelerate the progress of the disease. "The ...Nobel Laureate Sydney Brenner receives 2005 UCSD/Merck Life Science Achievement Award
...nd organs develop. During his career, Brenner also demonstrated that a chemical could produce specific genetic mut...r mRNA, which can be translated into proteins, and demonstrated that the nucleotide sequence of mRNA determines the order of amino acids in proteins. For these disc...SERPINE2 identified as novel candidate gene for COPD, especially with smoking
...ar adventitia. Immunohistochemistry in human lungs demonstrated an analogous staining pattern. "Our studies revealed cell-specific and developmentally-regulated expression of SERPINE2 in the lung, which supports further investigation of this gene's role in human lung diseases," Srisuma said. Next steps. Already ...15 generations of untrained jocks, couch potatoes show big physiological adaptations
...ications for human attitudes and therapies Having demonstrated the genetic role in endurance performance and the oxygen delivery systems, the group of researchers are turning their attention to identify the various genes involved that provide the underlying signal for "why" some subjects become more athletic, wh...Alcohol 'binges' in rats during early brain development cause circadian rhythm problems
...alcohol during a period of rapid brain development demonstrated significant changes in circadian or 24-hour rhythms as adults. The alcohol dosage was the equivalent of several nights of binge drinking on the part of a pregnant woman, and it was given at a time during rat brain development (shortly after birth) eq...Automated imaging screen reveals promising drug candidates
...n explore. But for now, Shokat and colleagues have demonstrated the power of using high-throughput image-based screening to identify small molecules both for probing cell biology and for identifying promising drug candidates....Chronic inflammation caused by too little stomach acid leads to gastric cancer
... in the March 31 issue of Oncogene, U-M scientists demonstrated that chronic gastritis progresses to gastric cancer in mice with abnormally low levels of gastrin a hormone that stimulates stomach lining cells called parietal cells to secrete hydrochloric acid. Other researchers have shown that over-production of...Scientists find molecular pathway suspected in precancerous stomach lesions
...ouse stomach and intestinal tissue, the scientists demonstrated that the signals that drive the differentiation of stomach lining are sent by a layer of cells, known as mesenchyme, that lie directly beneath the intestinal lining. The key player in the signaling pathway, they found, is a transcription factor a pr...New alloy verified for safer disposal of spent nuclear energy fuel
...arch conducted by Lehigh and the two national labs demonstrated that gadolinium can be added to specific nickel alloys and retain its malleability and ductility, as well as its ability to be heat-treated, shaped and fabricated readily into a desired shape. More importantly, says DuPont, gadolinium has a neutron-a...VCU research shows Viagra prevents anti-cancer drug induced heart damage
...al of the American Heart Association , researchers demonstrated for the first time that administration of clinically relevant doses of Viagra, generically known as sildenafil citrate, one-hour prior to the administration of the anti-cancer drug doxorubicin (DOX) prevented heart damage at the cellular level. The r...Molecular testing impact: Heart transplant patients benefit from new technology, easier monitoring
... biopsy. The clinical value of AlloMap testing was demonstrated in a landmark multi-center, prospective study known as the Cardiac Allograft Rejection Gene Expression Observational (CARGO) study, which was presented at ISHLT's 2004 meeting. During today's symposium, Howard Eisen, M.D., will review the results o...Alfred G. Knudson Jr., receives American Association for Cancer Research Lifetime Acheivement Award
...a lasting impact on the cancer field and must have demonstrated a lifetime commitment to progress against cancer. The award joins the Landon Prizes, Pezcoller Foundation Award and numerous other scientific honors conferred annually by the AACR to recognize world-class accomplishments in basic research, clinical c...Yale researchers use laser light to remote control flies
...on of their flight. These responses to laser light demonstrated a direct link between specific neurons and specific behaviors. Gero Miesenbck , associate professor of cell biology at Yale, and principal investigator of the study, explained that the photoreceptors are ion channels that spark action potentials ...Protein tags regulate key ion channel
...e second protein functions. Goldstein's team first demonstrated that the SUMO-conjugating enzyme was plentiful at the plasma membrane, just inside the cell surface. They next showed that it added SUMO to a specific part of the K2P1 channel, and that when this happened the channel was entirely silent. When a diffe...Fibril shape is the basis of prion strains and cross-species prion infection
...rnal Molecular Cell, Surewuicz and colleagues also demonstrated that a "preseeding" process between animals with different prion amino acid sequences could overcome species barriers. For instance, mouse prion fibrils normally infect humans but not hamsters. But when mouse prions were brought into contact with ham...Australian kidney researcher applauded
...es in scientific and medical research that lead to demonstrated or potential benefit to human health, a requirement of the GlaxoSmithKline Award for Research Excellence is that the majority of the research is undertaken in Australia. Recipients receive an honorarium of $50,000 to acknowledge their discovery and ...New findings in taste and smell research
...en termed hV1RL1-5, one of which has recently been demonstrated to be expressed in the human main olfactory epithelium (MOE). Since nothing was known about their function, all five human V1RL-receptors had to be addressed as true orphan receptors, so far. We found that four out of five V1RL-receptors are expresse...New findings support a central role for NMDA receptors in learning and memory
...ive learning and long-term memory. The researchers demonstrated this active requirement by molecularly disrupting previously normal, functioning NMDA receptors in an adult fly and then showing that the fly had major difficulties in learning to associate an odor with a footshock--something that normal flies can qu...New gas sensors patterned with conducting polymer
...mer films on miniaturized device features has been demonstrated by researchers at the National Institute of Standa...es gaseous molecules. So far NIST researchers have demonstrated that such coatings can detect the difference between methanol and water vapor. Additional tests will......an image subsurface structures under skin has been demonstrated by scientists at the National Institute of Standar...eatures of various materials scatter light. It was demonstrated with small pieces of pigskin and inorganic materials but might eventually prove useful for imaging l...