Biological importance of basal activity of appetite suppressor
...Deletion of the N-ter-minal portion of the protein demonstrated that it is required for this basal activity. Further analysis proved that this domain func-tions as an intermolecular self-activating ligand that does not mimic manner in which a-MHC activates MC4R. The work here suggests that in devising therapies f...Antibiotic identified as potential anti-cancer candidate
...ss of new actinonin-based Pdf inhibitors, and have demonstrated that they selectively inhibit growth in several human tumor cell lines. They further demonstrate that human tumor growth in mice can be suppressed by these Pdf inhibitors and suggest a mechanism of actinonin action. Taken together, these data have ...S1P1 essential for tumor growth and is blocked by RNA interference
...gosine 1phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference AUTHOR CONTACT: Timothy Hla University of Connecticut Health Center, Farmington, CT 06030, USA Phone: (860) 679-4128; Fax: (860) 679-1201; E-mail: hla@nso2.uchc.edu View the PDF of this article at: http://www.jci.org/...Mice thrive despite massive genetic makeover
...te (JGI) and Lawrence Berkeley National Laboratory demonstrated that, after deleting large swaths of DNA sequence shared by mice and humans, they were still able to generate mice that suffered no apparent ills from their genomes being millions of letters lighter. The research findings are published in the Octo...Single genetic defect links many risk factors for heart disease and stroke
For the first time, researchers have demonstrated that a single change in a person's DNA can contribute to a range of life-shortening risk factors, including high blood pressure, high cholesterol, and other metabolic disorders. The mutation affects the genes of the mitochondria the energy-producin...Three years of Proba, the 'smart' satellite that runs itself
...oba Project Manager. "The mission has successfully demonstrated a number of sophisticated technologies in addition to new approaches in spacecraft construction and operations. "It has 100% lived-up to its full name of 'Project for On-Board Autonomy' for every day of the last three years the spacecraft performed...Brain differences in adolescents, psychopaths, lend to their impulsive, risk-taking behavior
...and pleasure. Consistent with this view, the model demonstrated that when the rewards were administered in an unpr...provoking areas than prepubescent rats. Adult rats demonstrated similar extension behaviors, but did not enter the anxiety-provoking areas, while the pubescent anim...Pesticides may promote Parkinson's disease and exercise may offer protection
...ing builds upon their previous study in which they demonstrated that rotenone, a commonly used agricultural pesticide made from the extracts of tropical plants, can reproduce parkinsonian features in rats. "Monkeys have a brain structure that is much more similar to humans than rats," notes J. Timothy Greenamyre...Study at Joslin shows ease of introducing technology to kids with diabetes
... encouraged by the results of this pilot study. It demonstrated the ease of introducing new technology to pediatric patients with diabetes, with an additional benefit of increased blood glucose monitoring among the Game Group participants," Dr. Laffel said. ...Children's Hospital Boston geneticist awarded for research on muscular dystrophy
...d muscle protein, dystrophin. In the 1990s, Kunkel demonstrated that injection of either blood stem cells or muscle stem cells can partially restore dystrophin in affected skeletal muscles, a finding that may lead to treatments for many types of muscle disease. More recently, Kunkel has defined the molecular and ...Emory study details dolphin brain evolution for the first time
...n addition to their large brains, odontocetes have demonstrated behavioral faculties previously only ascribed to humans and, to some extent, other great apes. These abilities include mirror self-recognition, the comprehension of artificial, symbol-based communication systems and abstract concepts, and the learnin...Gene therapy approach reverses diabetic neuropathy in animal model, Pitt study finds
...e University of Pittsburgh School of Medicine have demonstrated for the first time that gene therapy can reverse diabetic neuropathy. While their studies have so far only involved mice, the results are significant because they provide the earliest evidence that such an approach might some day help people with dia...Moffitt doctor's talk on ovarian cancer receives international first place award
...lysis. Data obtained from cancers of patients who demonstrated a complete response to platinum-based therapy was compared with those from patients who did not respond. At the IGCS conference, leaders from around the world came together to examine current issues surrounding gynecologic cancer. Members had the ...Humans and dolphins: If brain size is a measure, we're not that different
...n the animals' lifestyles. Odontocetes have demonstrated behavioral faculties previously only ascribed to humans and other great apes. These abilities include mirror self-recognition, the comprehension of artificial, symbol-based communication systems and abstract concepts, and the learning and intergenera...Paratek Pharmaceuticals presents multiple sclerosis data at Society for Neuroscience annual meeting
...y Dr. Luanne Metz at the University of Calgary has demonstrated disease protection in MS patients treated with min...tetracycline compounds, with different structures, demonstrated activity in reducing limb paralysis in the preclinical EAE (Experimental Autoimmune Encephalomyeliti...VYTORIN (TM) superior again to Lipitor at lowering LDL (bad) cholesterol
... not take VYTORIN. Study results also demonstrated VYTORIN increased HDL cholesterol by a greater deg...veraged across all doses, both VYTORIN and Lipitor demonstrated a mean 25 percent reduction on CRP after six weeks of treatment. "In addi...Is the zebra fish leading us to new therapies?
...molecule receptor for nerve cells, the researchers demonstrated that zebra fish that are unable to produce UNC5B construct a blood vessel network with uncontrolled branches and divergent patterns. This indicates that the receptor and the signal molecule are of crucial importance in guiding new blood vessels. Scie...Researchers tracking sources of arsenic contamination in water
...merica in Denver Nov. 7-10. Since health data have demonstrated that arsenic is a carcinogen, the U.S. standard for arsenic in drinking water has been lowered from 50 to 10 parts per billion, which is the same as the European Union standard, said Madeline Schreiber, assistant professor of geosciences. She and ass...Antibiotic-resistant bacteria increased after clindamycin use for common vaginal infection
...ewer than 1 percent of bacterial samples we tested demonstrated resistance to metronidazole," said Dr. Beigi. "In contrast, 12 percent demonstrated baseline clindamycin resistance, and 53 percent demonstrated resistance to clindamycin after therapy...Safety and immunogenicity data available for new pertussis booster vaccine candidate for adolescents
...ed] in whom efficacy against pertussis disease was demonstrated in a previous study. Currently, pertussis vaccination in the U.S. is only approved for children under the age of seven. Immunity from childhood vaccination generally wears off after five to 10 years, leaving many adolescents susceptible to this hig...