UCI researchers use human embryonic stem cells to aid spinal cord injury repair
...g around neurons in the spinal cord. These studies demonstrated that the oligodendrocytes derived from human embryonic stem cells can function in a living system. Results of this study are published online in the peer-reviewed journal "Glia." "These results are extremely exciting and show great promise," Keirst...Are animals as irrational as humans?
...n whether irrational decisions have been correctly demonstrated in animals. The authors suggest that observed "breaches of rationality" may stem from differences in the physiological state of animals "unwittingly imposed" by experimental design rather than from real irrational decisions. To test this, the re...Studies in Royal Society journals include stress in birds and depletion of medieval fish stocks
...d and predator effects on demography we previously demonstrated in song sparrows. We suggest inseparable food and predator effects on both physiology and demography may be the norm in birds and mammals. Contact: Dr Michael Clinchy, Biology, University of Western Ontario, LONDON, ONTARIO, N6A 5B7, Canada The ori...Finding could improve safety of stem cell transplants
...says Dr. Bieberich. Drs. Bieberich and Condie demonstrated in the Aug. 4, 2003 issue of The Journal of Cell Biology that a natural process occurs during development to eliminate excessive and potentially harmful cells. Just before neurons begin forming, there is a massive production of proteins and up-regula...Psychological stress and disease: UCSF-led study suggests connection
... from mind to body "Numerous studies have solidly demonstrated a link between chronic psychological stress and indices of impaired health, including cardiovascular disease and weakened immune function," says lead author Elissa Epel, PhD, UCSF assistant professor of psychiatry. "The new findings suggest a cellula...Improved molecular switch could serve as sensor, medical tool
...ls the activity of the other. Lab experiments have demonstrated that the new switch performs 10 times more effecti...on earlier research, led by Marc Ostermeier, which demonstrated that it was possible to create a fused protein in which one component sends instructions to the othe...Gene therapy shows promise in model of Parkinson's disease
...mechanisms behind the disease, says Lo Bianco. "We demonstrated for the first time the feasibility of the gene therapy approach in a genetic model of Parkinson's disease." Results of this research might lead to new treatments that could prevent the onset of Parkinson's disease in genetically predisposed subject...Computer analysis shows scientists could reconstruct the genome of the mammalian common ancestor
...overed. Nevertheless, a team of scientists has now demonstrated that computers could be used to reconstruct with 98 percent accuracy the DNA of a creature that lived at the time of the dinosaurs more than 75 million years ago--a small, furry nocturnal animal that was the common ancestor of all placental mammals, ...Vaccination with anthrax capsule protects against experimental infection in animals
... vaccine resulted in survival of 9 of 11 mice. "We demonstrated that protection was even greater when the capsule was combined with PA, compared to when PA was given alone," Friedlander said. "A different formulation could make it even better. The next step will be testing in additional animal models." Friedlande...JCI table of contents, December 1 2004
...ath of cells within the gut. Previous studies have demonstrated that treatment of mice with protaglandin E2 (PGE2)...mune arthritis in mice lacking IL-1Ra. The authors demonstrated that mice deficient in both T cells and IL-1Ra did not develop arthritis. Arthritis development also...Save up your energy reserves for a longer life!
...c and molecular tricks on nematode worms, the team demonstrated that animals with extra copies of the AMP-1 enzyme... 13% longer lives than controls. Other experiments demonstrated that environmental stressors that activate the AMP-1 enzyme, also lead to longer lived animals. In a...New drug sidesteps Gleevec resistance in human trials
... the journal Science , Sawyers and his colleagues demonstrated that BMS-354825 prolongs survival of mice with CML. In tests with cultured human bone marrow cells, the researchers showed that the drug inhibits the proliferation of bone marrow progenitor cells that are positive for BCR-ABL in patients who are resi...Wolves gone, western ecosystems suffer
...onal Park or the mountainous regions around it, as demonstrated by a broad range of research. One study suggested that the loss of wolves has allowed increases in deer populations across much of North America, which led to a browsing pressure on plants that was unprecedented. Predation effects involv...Study by US, Hebrew University scientists sheds light on how bacteria persist despite antibiotics
...usalem and Rockefeller University in New York have demonstrated the constant presence of antibiotic-tolerant "persistent cells" within bacteria colonies and have shown, through mathematical modeling, how these cells develop into "normal" cells following their survival of even heavy dosages of antibiotics. The fi...Research points to new theory driving evolutionary changes
...area where humans have evolved rapidly. "We have demonstrated that the tandem repeat sequences found in many genes are probably responsible for rapidly evolving physical traits that affect a species' ability to survive," Dr. Garner said. "Dogs have been rapidly bred to have many different shapes and traits that...New model of rare childhood blindness holds promise for testing preventive therapies
...one formation. However, the St. Jude-Columbia team demonstrated the link between the absence of AIPL1 during fetus development and the loss of vision that occurs shortly after birth. Based on this work, the investigators believe that the AIPL1 gene plays at least two critical roles in the eye development. "We...Alcohol vulnerability linked to action of insulin
... effect of alcohol increases. Earlier research has demonstrated that the flies and humans display many of the same vulnerabilities and behavioral responses to alcohol. "This finding opens promising new avenues for the treatment of alcoholism," said Ulrike Heberlein, PhD, UCSF professor of anatomy and senior a...APS announces 2005 Distinguished Lecturer Awards
...anding contributions to physiological research and demonstrated dedication and commitment to excellence in training of young physiologists. An award luncheon honoring Dr. Carter-Su will be held on April 2, 2005. DISTINGUISHED LECTURESHIPS Recipients of these Distinguished Lectureships are chosen by the 12 APS...Laser scalpel opens way for nerve regeneration studies in worms
...pulable animal. Indeed, their initial studies have demonstrated that the severed nerves of worms are capable of regenerating and regaining full function.According to the researchers, studying nerve regeneration in the worm could provide answers to questions that are not accessible currently by doing experiments i...... of stem cells leading to osteoporosis. Given the demonstrated influence of the caspase-3 inhibitor on bone miner... that EphB6 modulates immune function. The authors demonstrated that mice genetically deficient for EphB6 have compromised T cell responses. On the other hand, immu...