Researchers report new pro-inflammatory role for anti-inflammatory enzyme
...ts in death." Previously, Dr. Hobbs and colleagues demonstrated in vitro that endothelial nitric oxide synthase (eNOS) also plays a pro-inflammatory role by facilitating iNOS expression. "eNOS is found almost exclusively in the vascular endothelium and the NO that it synthesizes plays a key role in regulation of ...Researchers rein in regulatory RNAs
...sawa also evaluated four Arabidopsis SAT pairs and demonstrated that these molecular characteristics were largely conserved in plants. "Conventional belief in molecular biology suggests that poly(A)+ mRNAs are major mediators in flows of genetic information," Abe explains. "However, the information obtained from...Polymers with copper show promise for implanted sensors
...se. A University of Michigan team that previously demonstrated improved accuracy with intravascular sensors that ...t include a copper ion-containing complex. They've demonstrated that complexed copper ions do have the desired catalytic effect when incorporated into a polymer and...UC Davis researchers discover new link between C-reactive protein, and heart disease and stroke
... at UC Davis Medical Center. "We have convincingly demonstrated in this paper that aortic and coronary artery endothelial cells produce and secrete C-reactive protein. We also showed within the artery, mature white cells, called macrophages, make chemical messengers, cytokines, which enhance the C-reactive protei...Variation in women's X chromosomes may explain differences among individuals, between sexes
...les lack. The incomplete nature of X inactivation, demonstrated in the new study, means that at least 15 percent of the X-linked genes, and their protein products, are present at characteristically higher, and often variable, levels in females compared to males. Moreover, the findings show that a minimum of an ad...High cholesterol levels accelerate growth of prostate cancer
Researchers at Children's Hospital Boston have demonstrated that high blood cholesterol levels accelerate the growth of prostate tumors, showing that cholesterol helps prostate tumors survive and grow at the molecular level by altering chemical signaling patterns within tumor cells. The findings, published ...Tips from the Journals of the American Society for Microbiology
...nhibition in HCV five days posttreatment. "We have demonstrated here that replication of HBV and HCV is sensitive to the antiviral activities of interferon lambda," say the researchers. "These results suggest the possibility that interferon lambda may be therapeutically useful in the treatment of chronic HBV or ...HHMI taps two Long Island researchers as among the nation's most promising scientists
...schools, and institutes to nominate candidates who demonstrated exceptional promise within 4 to 10 years of their becoming independent scientists. More than 300 individuals were nominated. Dr. Lowe is Deputy Director of the CSHL Cancer Center and is a world leader in the field of cancer biology. His research is ...DNA 'packaging' linked with cancer
...as affected," Folberg said. Additional experiments demonstrated that the molecules outside a cell exert their influence not by chemical means but mechanically, manipulating the skeletal framework of the cell and the proteins that envelop DNA. These proteins keep the string of DNA -- really, a stiff wire with comp...Harvard, Texas A&M scientists develop new laser
...as homeland security. "While our paper merely has demonstrated proof of concept, one day it may lead to the sort of security experts dream of having-a portable device that you could use to detect things like weapons or explosives simply by shining an invisible light to see what someone might be hiding," Capasso ...UCSD researchers maintain stem cells without contaminated animal feeder layers
...e absence of contaminated animal products has been demonstrated by University of California, San Diego (UCSD) School of Medicine researchers in the Whittier Institute*, La Jolla, California. Published in the April 2005 issue of the journal Stem Cells, the study shows that laboratory culture media enriched by a hu...UT Southwestern researchers uncover gene variant that appears to predict type 2 diabetes
...resistance. Now, Dr. Abate and his associates have demonstrated that this gene's effects on insulin resistance have biological significance in that its abnormalities make it more likely that people will develop diabetes," Dr. Grundy said. "This study is particularly revealing because of the past difficulty in ide...Genetically modified natural killer immune cells attack, kill leukemia cells
...the current online issue of Blood. The researchers demonstrated how to overcome significant technical hurdles that have until now slowed development of NK-based therapies for ALL, according to Dario Campana, M.D., Ph.D., a member of St. Jude Hematology-Oncology and Pathology, and senior author of the Blood report...Vital step in cellular migration described by UCSD medical researchers
...'s immune response to invading pathogens, has been demonstrated by researchers in the University of California, San Diego (UCSD) School of Medicine. Published in the March 27 online edition of Nature Cell Biology and the journal's upcoming April print edition, the study describes how a the interaction of alpha4 ...Essential mangrove forest threatened by cryptic ecological degradation
...rnational team led by Dr. Farid Dahdouh-Guebas has demonstrated that in the recent past an increase in human-environment interactions that affect the hydrology of rivers has turned coastal mangrove lagoons into freshwater bodies. Such elucidation of past ecosystem processes and human-environment interactions is a...Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
...e had been rendered nonfunctional, the researchers demonstrated they could introduce the functioning gene and correct glycogen buildup in heart and skeletal muscle. The findings suggest that such an approach should be considered as a potential gene therapy strategy for Pompe disease patients, the researchers repo...DFG awards 2005 Heinz Maier-Leibnitz Prize
...ohn Milton's literary classic "Paradise Lost", she demonstrated that the 17th century novel reflected the politica...onomic situation in England at that time. She also demonstrated how Milton's book influenced the imperialism debate in the aspiring empire. Using methods from compa...Glowing hearts shine light on heart disease
...ntenance of normal rhythm. Several years ago, they demonstrated in a mouse model of cardiac hypertrophy that blocking CaM kinase activity suppresses arrhythmias. At the same time, evidence from other laboratories began to suggest that CaM kinase's role in structural heart disease went beyond the electrical signal...Natural tumor suppressor in body discovered by UCSD medical researchers
...ue of the journal Molecular Cell. The scientists demonstrated that PHLPP deletes a phosphate molecule, causing termination of cell-growth signaling by a protein called Akt that controls the balance between cell growth leading to cancer and cell death that prevents tumor formation. "A drug that turns on PHLPP, s......telomere lengths. Using biochemical assays, it was demonstrated that MKRN1 directly interacts with hTERT to promote the addition of the ubiquitin moieties. These results indicate that two opposing forces in human cells influence basal levels of active hTERT. The first is an interaction with Hsp90 that promotes t...