JCI table of contents July 1, 2005
... to normalcy by treating the mice with human CHGA, demonstrating that the human gene plays a role in autonomic control of blood pressure. An accompanying commentary by Taeyoon Kim and Y. Peng Loh states that one important clinical implication of this work is that CHGA may be used as a therapeutic agent for treati...AGI becomes founding partner of the International Year of Planet Earth
... conceptual and operational aspects of IYPE, while demonstrating AGI's preparedness to invest ininternational geoscience operations and activities. "AGI's active involvement would guarantee a trulyglobal balance in the science and outreach programs of IYPE," says Stephen Testa, president of AGI. IYPE was initiated...Divergent life history shapes gene expression in brains of salmon
...prised by some of the 17 separate classes of genes demonstrating differing activity levels. "It makes sense that growth genes are suppressed in sneakers and genes associated with reproduction are expressed more, since these fish essentially trade bodily size for faster reproductive maturity," she says. "However, i...Don Quixote's home shows way to future Earth Observation missions
...ut in Barrax last month between 30 May and 4 June, demonstrating the capability of test sensors to detect variability among vegetation species and developmental states, but also to monitor changes in the same fields as crops grew from the six weeks between the previous measurements in June. The first objective of...Using nanoparticles, in vivo gene therapy activates brain stem cells
...ctivate adult brain stem/progenitor cells in vivo, demonstrating that it may be possible to "turn on" these otherwi...- took up and expressed a fluorescent marker gene, demonstrating the ability of nanoparticle technology to deliver effectively genes to specific types of cells in th...One hit of crystal meth causes birth defects: U of T study
...other malformations but this is the first research demonstrating that even a single exposure can cause long-term damage," says Wells. "It's pretty remarkable that a single low dose can have such an effect. "It's an important finding, given the increasing use of club drugs among women of childbearing age. It has cl...Chemical link indicated between drinking and certain cancers
...oholism (NIAAA), National Institutes of Health, in demonstrating a potentially important chemical link between alcohol consumption and cancer. Using this novel chemical assay, they have uncovered a chain of chemical reactions that, under physiological conditions, may lead from alcohol to a known mutagen. It has be...No small feat: First ever gene therapy success for muscular dystrophy achieved
...nt of congenital muscular dystrophy (CMD) in mice, demonstrating that the formidable scientific challenges that have cast doubt on gene therapy ever being feasible for children with muscular dystrophy can be overcome. Moreover, their results, published in this week's online edition of the Proceedings of the Nation......t also completed CT scans on about 20 bat species, demonstrating that the ear shape of bats varies enormously, and heavily influences their performance. This knowledge could also be used to enhance the performance of existing sonar systems. "We're the first to build a high resolution computer model of bat ears, wh...Caloric restriction won't dramatically extend life span in humans: UCLA research
...me." Phelan developed the first mathematical model demonstrating the relationship between caloric intake and longevity, using representative data from controlled experiments with rodents, as well as published studies on humans, diet and longevity. He and Michael Rose, professor of ecology and evolutionary biology ...Human Y chromosome stays intact while chimp Y loses genes
...landmark paper in Nature challenging that claim by demonstrating how a certain region of the Y chromosome possessed a unique mechanism for repairing mutated genes. Through sequencing the Y, the Page lab and collaborators at Washington University School of Medicine in St. Louis discovered that many of its genes we...Robot exhibition to highlight WTEC international study of robotics
...available to answer questions. Researchers will be demonstrating their robots, including a team from the Johns Hopkins University that is also funded by the NIBIB. Drs. Russell Taylor and Peter Kazanzides will showcase virtual fixtures for neurosurgical applications such as aneurysm clipping and skull base drillin...Canadian cancer researchers win prestigious award for their stem cell research
... being honoured for their groundbreaking discovery demonstrating the existence of stem cells in the blood-forming system. In the early 1960s, their discovery laid the foundation for human bone marrow transplantation for patients with leukemia and other cancers. "Drs. Till and McCulloch motivated me as a young scie...Breakthrough in micro-device fabrication combines biology and synthetic chemistry
... to the study's lead author, Kenneth Sandhage, "By demonstrating that biologically derived structures can be chemically modified without changing the starting shapes or fine features, we have opened the door for new research and development in the processing and application of many devices that would otherwise be ...Study in Royal Society journal on first observation of giant squid in the wild
...ummingbirds. McWhorter et al. report new findings demonstrating that passive absorption of glucose is much higher in hummingbirds than previously thought. Even while possessing the highest active glucose absorption rates measured in vertebrates, hummingbirds must rely partially on passive nutrient absorption to ...EPA-led group finds same protein that attracts nutrient iron protects lung from particles
...p of EPA-led lung researchers reported experiments demonstrating for the first time that "DMT1 is essential for the transport and detoxification of some metals associated with an air pollution particle that damages the pulmonary epithelial surface." The paper "Divalent metal transporter-1 decreases metal-related ...Neural stem cells are long-lived
...arated by a year, the quiescent cells recovered -- demonstrating that the cells could still respond to Shh signaling. That the quiescent stem cells remained capable of self-renewal after a year in both normal and AraC-treated mice was a central finding of the study, said Joyner. "It has been assumed that these cel...A novel mechanism of action for anti-tumor agent, CA4P
...nell University provide important mechanistic data demonstrating how CA4P has anti-tumor and anti-angiogenic activity. The authors find that CA4P selectively targets endothelial cells (flat-shaped cells that make up the inside of blood vessels) but not smooth muscle cells (cells which surround most blood vessels)...JCI table of contents November, 2005
...nell University provide important mechanistic data demonstrating how CA4P has anti-tumor and anti-angiogenic activity. The authors find that CA4P selectively targets endothelial cells (flat-shaped cells that make up the inside of blood vessels) but not smooth muscle cells (cells which surround most blood vessels)...New GM mosquito sexing technique is step towards malaria control, report scientists
...rlier work by the Imperial team published in 2000, demonstrating for the first time the insertion of a foreign gene into the mosquito genome. This raised the possibility that genetic manipulation could be used as a control method in mosquito populations. Professor Crisanti adds: "Although there have been a number ...