Prenatal genistein in soy reduces obesity in offspring
...d the offspring's coat color from yellow to brown, demonstrating that a single nutrient can have a widespread systemic impact, said the researchers. Genistein's effect occurred early in pregnancy, the equivalent of eight gestational days in humans. The Duke scientists said their results lend support to the "develo...First clinical trial of gene therapy for muscular dystrophy now under way
...hin gene forward clinically. "We had just finished demonstrating that we could make clinical-grade virus for anothe... required by the U.S. Food and Drug Administration demonstrating that minidystrophin gene transfer was unlikely to harm and could ultimately benefit muscles affected...Scientists elucidate the kinome of key model organism
...ways in other organisms, including vertebrates, by demonstrating what aspects of signaling are conserved, and revealing opportunities to use Dictyostelium to understand important human proteins."...Plexxikon advances first oncology development candidate
...h, Plexxikon scientists presented preclinical data demonstrating that a low dose of this oral V600E B-Raf inhibitor preferentially stopped tumor growth in malignant melanoma and colorectal cancer cells. In the oral presentation titled "Development of a Novel Inhibitor of Oncogenic B-Raf," (Abstract #2412), Plexx...Fox Chase Cancer Center study shows that inhibitors of (FAP) attenuate tumor growth in mice
...pported by previous studies by the Fox Chase group demonstrating that FAP increases the growth of an experimental kidney epithelial tumor (HEK293) in mice. The DPP enzymatic activity of FAP was shown to be important for tumor growth, suggesting FAP as a molecular target in cancer. By targeting FAP, agents that inh...LIAI scientists make major finding on potential cure for type 1 diabetes
..., called the finding "a very important discovery, demonstrating synergistic efficacy of two therapies (anti-CD3 and proinsulin immunomodulation) that are in human studies for the prevention of type 1 diabetes." Dr. von Herrath's approach focuses on teaching the immune system to tolerate, rather than attack, the ...Diverse tropical forests defy metabolic ecology models
... the process The CTFS team did not stop at merely demonstrating that metabolic ecology failed to explain tropical forest structure '" they examined what alternative models might do better. Organisms live within the limits of their environment. Maybe by modifying the metabolic ecology model to include light as a...Tyler Environmental Prize winners announced
.... Dave Schindler did the right set of experiments demonstrating beyond any reasonable doubt that P (phosphorus) controls the eutrophication of temperate lakes, Vitousek wrote. Dr. Schindler then took the same approach to the issue of acid rain. Other people did good work on acid rain effects and some of them sp...Anthrax inhibitor counteracts toxin, may lead to new therapeutics
...esigning a polyvalent inhibitor for cholera toxin, demonstrating that this approach also could be used successfully to enhance the potency of polyvalent inhibitors directed to this target and, they suggest, others. They note the work also could be useful for creating specific target recognition in biological senso...Male rivalry increases when females at most fertile, say researchers
...r features are linked to high testosterone levels, demonstrating good genetic qualities that can be passed on to offspring. New research at the University has found that men sense this preference shift in their female partners and find masculine men more threatening during their partner's most fertile phase. Rob...Targeted virus compels cancer cells to eat themselves
...ells while sparing normal tissue. In addition to demonstrating the therapeutic potential of the virus, called hTERT-Ad, Kondo says the international research team also clarified the mechanism by which such conditionally replicating adenoviruses (CRAs) infect and kill cancer cells. Autophagy is a protective proc...New findings help pinpoint autism's genetic roots
...istic disorders; however, this is the first report demonstrating such an imbalance. Lead authors in the Pten study from the Center for Developmental Biology were Dr. Chang-Hyuk Kwon, postdoctoral researcher; former graduate student Bryan Luikart, now at Oregon Health & Science University; and Dr. Craig Powell, as...ESA to host Atmospheric Science Conference
...performance, data processing and data quality; (d) demonstrating the synergistic use of atmospheric and optical instruments; and (e) formulating recommendations for algorithm development. The conference, with some 250 participants expected to attend, will include presentations that detail the current use of sate...Non-coding RNAs help silence the mammalian transcription
... insight into the mechanism of genomic imprinting, demonstrating a necessary role for a non-coding RNA transcript in the silencing of an imprinted gene cluster in mice. Imprinting, or the differential expression of a gene based upon which parent it has been inherited from, is integral to normal growth and developm...New compound reduces stroke damage
...amatically decreases the damage to neurons in rats demonstrating stroke symptoms. The research appears as the "Paper of the Week" in the May 26 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal. Stroke is the third leading cause of death in the United ...Full year of treatment helps infants and children with toxoplasmosis
...tients had normal long-term cognitive outcomes. By demonstrating the benefits of diagnosing and treating the infection, these findings have renewed the call for comprehensive screening for this acute parasitic infection in pregnant women and newborns. "We now know that we can improve longer-term outcomes if we tre...Even when faint, ovary scent draws sperm cells
... some sperm cells still found their mark. A video demonstrating sperm chemotaxis (oriented motion in response to a chemical gradient) can be downloaded at http://www.iuinfo.indiana.edu/bem/media_relations/movie.chemotaxis.mpg (Credit: Stephen C. Jacobson, 2006). "Sperm are known to exhibit chemotaxis toward extr...Injecting stem cells from a woman's own muscle may effectively treat urinary incontinence
...niversity of Pittsburgh School of Medicine. "We're demonstrating for the first time that we may be able to offer people with SUI a long-term and minimally invasive treatment." In the study, researchers took biopsies of skeletal muscle tissue from seven female patients and isolated and expanded the stem cells from ...New study reveals components of cocoa may enhance the appearance of the skin
...rch on cocoa flavanols over the last several years demonstrating their potential positive benefits on circulation, it is rewarding to see that these benefits may extend to skin quality as well." In addition to the improvements in skin quality in study participants, this study is the first to suggest that the regul......t the University of Oklahoma will present research demonstrating the technical feasibility of using detergent-producing microorganisms to recover entrapped oil from oil reservoirs. "Our approach is to use microorganisms that make detergent-like molecules (biosurfactants) to clean oil off of rock surfaces and mobi...