Joslin researchers pinpoint causes of adverse reactions to popular type 2 diabetes drugs
...n the wild-type mice but not in the knockout mice, demonstrating that RSG-induced activation of PKC-beta is involved in these side effects," says Dr. King. The finding also suggests a potential treatment. Over a decade ago, Joslin researchers began working on PKC-beta inhibitors that would block PKC-beta activity...Parallel evolution: Proteins do it, too
... so it can better digest food." Even after clearly demonstrating parallel evolution in this case, Zhang believes the phenomenon is uncommon at the protein sequence level. However, he proposes a list of criteria in the Nature Genetics paper that he and other researchers can use to test apparent examples in the futu...LSUHSC research finds evidence of RNA in structures essential to cell division
... developed, extracted a set of RNAs called cnRNAs, demonstrating their association with centrosomes biochemically and in situ. Exhaustive database analysis revealed no matches to known nucleotides, translated nucleotide, or predicted protein sequences, founding the conclusion that they are unique and intrinsic to ...UCSD researchers develop 'smart petri dish'
...assays are able to detect a decrease in viability, demonstrating the potential of the technique as a complementary tool for cell viability studies." In addition, they add, their method "is noninvasive and can be performed in real time, representing a significant advantage compared to other techniques for in vitro ...Midgets and giants in the deep sea
...marine animals yielded contradictory results, some demonstrating a trend toward larger animals at greater depths and others showing smaller animals in deeper water. In keeping with the island rule, the current study suggests that both size trends may occur simultaneously, depending on the initial size of the anima...Sleep strengthens memories and makes them resistant to interfering information
... and extends previous study of sleep and memory by demonstrating that sleep does not just passively and transiently protect memories; rather, sleep plays an active role in memory consolidation....Neandertal genome to be deciphered
...ääbo TM s research group has developed methods for demonstrating the authenticity of ancient DNA results, as well as technical solutions to the problems of working with short, chemically-modified DNA fragments. Together with 454 Life Sciences they will now combine these methods with a novel high-throughput DNA seq...Research simplifies diagnosis of Charcot-Marie-Tooth disease
...IB) connected to the University of Antwerp are now demonstrating that mutations in mitofusin 2 are the major cause of CMT2, a specific type of the disease. These findings are important for a better understanding of CMT in general, and they also form the basis for a genetic test for CMT2. This test is already avail...Preventing ventilation induced lung injury depends on giving the right number of 'sighs'
... was akin to a high tidal volume group, once again demonstrating that low tidal volume is safer. The control group that received high tidal volume but no PEEP showed the highest evidence of injury, even higher than the high tidal volume group. This indicates that PEEP helps reduce the negative effects of frequen...Groundbreaking research highlights myriad health benefits of flavanol-rich cocoa
...it adds to the growing body of scientific research demonstrating that the consumption of flavanol-rich cocoa can potentially lead to a range of physiological benefits resulting from improved blood flow." Researchers studied the effects of cocoa flavanols in vitro (test tube) and in human subjects, on various age g...Nanotechnology enables low-dose treatment of atherosclerotic plaques
...e considered to be at an early stage of growth. By demonstrating the utility of the nanoparticles for early intervention of atherosclerosis, the research group hopes that they can help alleviate the need for more invasive treatment of later-stage atherosclerosis. "We wanted to go after the early stages of the dis...Iowa State researchers convert farm waste to bio-oil
...newable energy. "My goal," he said, "is to keep on demonstrating this for all the farmers around."...Apes -- not monkeys -- ace IQ tests
... resulted from particular testing situations -- by demonstrating that some primate species surpassed others across a wide range of problem-solving tests. Primates are an excellent comparison group because their similar perceptual and motor skills means that the same tests are generally appropriate for all of them,...Metal homeostasis research in plants will lead to nutrient-rich food and higher yielding crops
...s similar to that of IRT1 loss of function plants, demonstrating that Cadmium transport through IRT1 has been eliminated. Furthermore, these plants have twice as much Iron as wild type plants when grown in the presence of Cadmium. While the ability to quantify the amount of particular metals present in various...New textbook uses real disease outbreaks to teach undergraduate microbiology
...s of microbiology to students while simultaneously demonstrating how microbiology affects their lives. Outbreak: Cases in Real-World Microbiology, from ASM Press uses 96 classroom-tested case studies that cover the core topics of microbiology and integrate recent outbreaks that have been featured in the news. "T...Today's babies are fatter babies
...tp://www.cdc.gov/growthcharts/ . "In addition to demonstrating that we are seeing more heavy infants today than we did 20 years ago, this study illustrates the usefulness of routinely collected information from doctors' offices to address a key public health issue," says Juhee Kim, PhD, first author of the study...Announcing the launch of Open Access Central
...ublishing thousands of peer reviewed articles, and demonstrating their quality with impressive Thomson Scientific (ISI) impact factors ( http://www.biomedcentral.com/info/about/faq?name=impactfactor ). Chemistry Central ( www.chemistrycentral.com ), also launched today, will publish peer-reviewed research in che...Gene variants reveal susceptibility to cardiovascular disease
...tor to influence the activity of many other genes, demonstrating how small genetic changes can influence multiple genetic outcomes. The researchers said they now can use molecular techniques to look at where GATA2 acts within the genome to see what other genes also contribute to cause cardiovascular disease. "...Science researchers genetically transform immune cells into tumor fighters
...immune cells to become specialized tumor fighters, demonstrating for the first time that these engineered cells can persist in the body and shrink large tumors in humans. Two of the 17 people with advanced melanoma who received the experimental treatment saw their tumors shrink and were declared clinically free...Research shows how ultrasound can deliver therapeutic molecules into living cells
...ss ultrasound effects and cell responses. Beyond demonstrating that ultrasound punched holes in cell membranes, the researchers also studied the mechanism by which cells repair the holes. After the ultrasound exposure, they introduced into the cell medium a chemical not normally taken up by the cells. By varyi...