Jefferson scientists identify gene mutation potentially involved in breast cancer initiation
...ercent of all breast cancers. "This is the first demonstration that a specific Caveolin-1 mutation is exclusively connected to being estrogen-receptor positive," says Dr. Lisanti, noting that in tests of breast tumor samples, none of those that were estrogen-receptor negative showed caveolin mutations. "One-thi...Sweet success for pioneering hydrogen energy project
...sil fuels. This was a highly successful laboratory demonstration of bacterial hydrogen production using confectione...at and caramel waste was introduced into a 5 litre demonstration reactor (although other similar wastes could be used). The bacteria, which the researchers had ident...Experimental vaccine protects nonhuman primates when given after exposure to Marburg virus
...results are very encouraging, as this is the first demonstration of complete post-exposure protection of nonhuman primates against a filovirus," said Thomas W. Geisbert, one of the USAMRIID investigators. Colonel George W. Korch, Jr., commander of the Institute, added, "This outstanding collaboration has been ins...Next phase reached in definition of Mars Sample Return mission
...recursor missions. Such missions would include the demonstration of critical technologies associated with, for example, soft-precision landing. As an outcome of this, a shortlist of candidate precursor mission concepts will be made. Both of these steps will be performed in close interaction with the scientific c...Physics and biology team up to tackle protein folding debate
...ne. Now the effort has borne fruit in an excellent demonstration of the potential of interdisciplinary research in physics and biology....3D ultrasound device poised to advance minimally invasive surgery
...e beating hearts of dogs. The engineers said their demonstration showed that the probes could give surgeons a better view during human endoscopic surgeries in which operations are performed through tiny "keyhole" incisions. If the probes prove beneficial in human testing, the advance might lead to more precise and...Cellular scale drug delivery from the inside out
...an be manipulated by a magnetic field. In a simple demonstration of the principle, Lin holds a refrigerator magnet up to a liquid-filled glass vial containing human cervical cancer cells grown in vitro that contain nanospheres capped with iron-oxide particles. The cells slowly migrate and cluster to the side of t...Driver of anthrax toxicity could lead to late-stage therapy
...ry of the role of LRP6 in anthrax toxicity and the demonstration that antibodies directed against the extracellular domain of LRP6 can protect cells grown in culture against killing by anthrax toxin suggest that the immunological targeting of LRP6 may prove useful in protecting against the effects of accumulated t...Through a satellite darkly: Night views of European seas improve ESA ocean heat map
...logical Institute. Medspiration is being run as a demonstration project up until the end of 2007, with user consultations taking place every six months the next being scheduled for June. The project will then be extended to cover requirements coming from the MARCOAST initiative to deliver a range of operational ...Gene influences antidepressant response
...t decisions. "To our knowledge, this is the first demonstration of significant, replicated association between genetic variation and outcome of antidepressant treatment," added Manji, director of the NIMH's Mood and Anxiety Disorders Program. In the initial phase of the NIMH-funded STAR*D (Sequenced Treatment Al...Penn clinical chemist wins prestigious Ullman Award
...plastic micro-structures and resulted in the first demonstration of numerous analytically useful processes in microchips, including immunoassay, assessment of sperm motility, and DNA amplification. Today many laboratories and companies have research and development programs based on Kricka's discoveries. "What we...To avoid doing more harm than good, land trusts must consider market forces when acquiring property
...onsible manner. These results provide a compelling demonstration of the need for land trusts to become more economically savvy in their operations."...Tips from the journals of the American Society for Microbiology
...te was 100%. "To our knowledge, this is the first demonstration of a bivalent EBOV vaccine to coexpress multiple serotype proteins in a single vaccine construct, eliciting efficient humoral and cellular immune responses to both SEBOV and ZEBOV antigens," say the researchers. (D. Wang, N.U. Raja, C.M. Trubey, L....Largest study of human 'interactome' reveals a novel way
...volved in genetic diseases," Pandey says. "And our demonstration that a protein's importance is not based on the number of interactions it has with other proteins is an important conceptual breakthrough. It eliminates a blind alley that could mislead researchers investigating the roles of specific proteins in the ...University of Leicester announces world first forensic technique
...ng and cause of death. Professor Rutty said: "The demonstration of the ability to utilise mobile MSCT technology under these circumstances may result in a complete rethinking of the type of radiology to be used in temporary mortuaries or mass fatalities scenes. The work presently being undertaken by my research ...At Berkeley: Intelligently designed molecular evolution
...want, even one that does not occur in nature, this demonstration represents a significant step in that direction. The idea would be to one day be able to design an enzyme synthase that would evolve along a specific functional pathway to yield a desired molecular product, then introduce it into microbes for mass p...X chromosome dosage compensation proven in germ cells
... to the other chromosomes. This study is the first demonstration that the X chromosome is upregulated in germs cell...mes back into balance. The study is also the first demonstration that upregulation of the X chromosome in somatic tissue is conserved across species. Vaijayanti Gup...Case biologists show that what a neuron can do is a function of mechanical context
...ut not in another. These studies provide the first demonstration of Bernstein's hypothesis in a behaving animal, and indicate that the behavioral roles of motor neurons can change depending on how parts of the body are positioned. The Case scientists have previously applied their research findings to the creation ...Cancer researchers found a new mechanism potentially explaining evolution of signalling pathways
...lation in mammals. The finding is the first clear demonstration of a major difference in the function of conserved signalling pathways between species. The results also show that multi-component pathways evolve, in part, by the insertion of novel proteins between existing pathway components. This insertion mechan...Researchers evolve a complex genetic trait in the laboratory
...nism and generated a brand-new polyphenism. Such a demonstration could offer important insights into the evolutiona... in the caterpillar. "Our work is really the first demonstration that genetic accommodation actually can happen," said Nijhout. "In this case, it happens in the labo...