Finding cures for tropical diseases: Is open source an answer?
...al diseases, such as African sleeping sickness and dengue fever. While patent incentives have driven commercial pharmaceutical companies to make Western health care the envy of the world, the commercial model only works if companies can sell enough patented products to cover their R&D costs and produce prof...UCI awarded $40 million to establish regional biodefense and infectious disease research center
... developing vaccines for arboviruses such as the dengue virus, which is spreading in Asia and Latin America; developing vaccines for devastating infections like Lassa fever; finding antidotes to botulism, a highly potent toxin; understanding how Burkholderia bacteria cause pneumonia and sepsis; and ...Mosquito study shows new, faster way West Nile can spread
...possibly other viruses such as the one that causes dengue fever. According to that theory, many vertebrates were considered to be "dead-end hosts" that did not pass along the virus. Only birds, which develop much higher levels of the West Nile virus in their blood, were thought capable of passing it on to ...Fragment of yellow fever virus may hold key to safer vaccine
...fever virus--and its flavivirus cousins, including dengue and West Nile look like balls covered by approximately 100 cross-hatched pairs of envelope proteins lying on the surface. The prongs of Y-shaped antibodies against yellow fever likely span the pairs by grabbing the essential epitope on one and the s...UQ leads $10m study to fight dengue
The spread of the life-threatening dengue fever virus could be stopped in its tracks if Univ...n the lifespan of mosquitoes that carry the deadly dengue virus. "This project, if successful, has the potential to dramatically improve the lives of people ...Fighting malaria by manipulating mosquitoes' sense of smell
...ase-carrying mosquitoes, such as those that spread dengue fever and those that carry the West Nile virus. In addition the project will test a basic approach that could be directed against a number of other insect species, including agricultural pests and those that carry other human and animal diseases. The...'Perfume' to lure mosquitoes and control malaria
...c mosquitoes, such as Aedes aegypti, which spreads dengue fever , and Culex pipiens, carrier of the West-Nile virus. The search for compounds affecting mosquito olfaction will initially be carried out in a system, developed in Carlson's laboratory, in which the mosquito receptors are made in the antenna of ...The cost of dengue fever challenges public health and national economies
Waltham, MA A new study of the disease burden of dengue fever in Malaysia strengthens the case for develop...d the rest for treating hospitalized patients with dengue fever, an often painful and sometimes fatal virus. These costs are equivalent to 940,000 lost workd...42 biomedical scientists worldwide named HHMI international research scholars
...ea Gamarnik will study the molecular mechanisms of dengue virus replication. It is estimated that more than 50 million human dengue virus infections occur annually in the tropical and subtropical regions of the world. Currently, nei...Secrets to antibody's success against West Nile Virus surprise scientists
...o serious complications or death. Like West Nile, dengue virus is a flavivirus spread by mosquito bites, but only in tropical regions of the world. The dengue virus is estimated by Centers for Disease Control and Prevention epidemiologists to cause100 million...Computer models aid understanding of antibody-dependent enhancement in spread of dengue fever
...lieve antibody-dependent enhancement may allow the dengue virus to grow more rapidly in people who were prev...ade-off between advantage and disadvantage for the dengue virus. The findings could one day lead to new strategies for developing and deploying vaccines. Usin...Biologists visualize protein interaction that may initiate viral infection
... on a cell's surface just after it attached to the dengue virus, a linkup thought to initiate the early stag...ions. During the earliest stages of infection, the dengue virus attaches to the "carbohydrate recognition domain," or CRD, of a key binding protein called DC-...Genetically engineered mosquitoes show resistance to dengue fever virus
...l of resistance against the most prevalent type of dengue fever virus, providing a powerful weapon against a...rst stable transgenic mosquito resistant to Type 2 dengue fever virus, the most prevalent strain of the disease. The mosquitoes that survived the procedure al...UCI professors Barbara Finlayson-Pitts and Anthony James elected to National Academy of Sciences
...netic approaches to interrupt malaria parasite and dengue virus transmission by mosquitoes. Recently, it was...l of resistance against the most prevalent type of dengue fever virus, providing a powerful weapon against a disease that infects 50 million people each year....Oswaldo Cruz Foundation, Virginia Bioinformatics Institute sign agreement...
...ent initiatives targeting healthcare solutions for dengue fever, hepatitis C, HIV/AIDS, influenza, malaria, ... the world population is at risk of infection from dengue according to recent estimates.(2) Initial targets for product development will include hepatitis C, ...First characterization of chikungunya viruses from Indian Ocean outbreak
...y are the same ones that transmit yellow fever and dengue fever in many parts of the world--which raises the possibility that the chikungunya virus could spread and cause disease elsewhere....UGA study explains peaks and troughs of dengue epidemics
...a. -- Scientists have long known that epidemics of dengue fever wax and wane over a period of several years,...f the four viral strains, or serotypes, that cause dengue explains the timing of epidemics. "We found that since about the mid 1980s, there's been a sequent...Genome circularization and RNA virus replication
... on their recent discovery of a novel mechanism of dengue virus replication. Approximately 50 million people are infected with dengue virus each year, resulting in about 24,000 deaths world-wide. Dengue virus is a mosquito-borne membe......gentina have identified a genetic element that the dengue virus uses to replicate, triggering the potentially fatal illness known as dengue hemorrhagic fever. In the August 15, 2006, issue of the journal Genes & Development, published o......ppening. Also, research on malaria, leishmaniasis, dengue and Chagas disease is of great national importance, even though treatments for such diseases are unlikely to generate large financial benefits," adds Todd Capson, the in-country program coordinator, who worked closely with Panama's Environment Author...