Turning a cellular sentinel into a cancer killer
...ad seen rapid appearance of tumors that progressed despite p53 expression, indicating that cancers can mutate to deactivate the pathway or circumvent it. Both Lowe and Jacks said they agreed that therapies aimed at reactivating p53 would still have to cope with the adaptability of cancers. "For any therapies...The floral network -- what determines who pollinates whom
... models. The authors argue that the neutral model, despite its appealing simplicity, can be discounted because it requires key assumptions regarding species abundances and random interaction that conflict with empirical observations of real communities. In contrast, the model combining barriers and complemen...New test predicts blood cancer's sensitivity to experimental cancer drug
...the survival of cells that are damaged or abnormal despite the body's efforts to eliminate them through apoptosis. Inspired by this pioneering research, drug companies have begun testing novel Bcl-2 inhibiting drugs designed to restart the natural death processes thwarted by the survival molecule. Letai ...Elderly's ability to manage the cold may be due in part to some aging processes of the body
...y for the elderly. Older people become hypothermic despite the fact that they are more likely to live inside a home than on the street, and nearly half who become hypothermic die. By contrast, children rarely succumb to the disorder. Younger adults are also less susceptible than the elderly, whose impai...Researchers develop new strategy for the treatment of CML
...l, which is responsible for this disease. However, despite initial success, patients eventually become resistant to imatinib mesylate. According to Steven Grant, M.D., Massey's associate director for translational research and co-leader of the cancer center's cancer cell biology program, and senior author...TIGR researchers reveal tricks of common sexually transmitted infection
...t continues to be ignored as a public health issue despite the high number of trichomoniasis cases in the world," said Trichomonas Genome Project director Jane Carlton, first author of the paper, who is now at the Department of Medical Parasitology, New York University School of Medicine. The study was funde......ne 14, 1856, watched by some 30,000 onlookers. But despite attempts to elicit a confession out of the condemned man, Palmer took his plea of innocence to the grave, leaving doubts over poison detection for others to ponder long after he had gone. In this challenging and entertaining new book, author Dr Ian ...New group of algae discovered: Picobiliphytes
...ntists have discovered a group of organisms which, despite being completely new to science, have a wide distribution. "This is a good indication for how much there is still to discover in the oceans, especially using molecular tools", says Valentin. Apart from the unfamiliar gene sequences, the researchers a...Delay in use of nevirapine-based AIDS treatment can improve outcomes
...f the minority of infants who become HIV infected, despite the use of single-dose nevirapine. Now, a team of researchers led by Shahin Lockman, Assistant Professor in the Department of Immunology and Infectious Diseases at Harvard School of Public Health (HSPH) and at Brigham and Women's Hospital, and Max ......f these aquatic organisms is far from being random despite long larval dispersal stages of several weeks," says Gerlach. "Apparently, these larvae--small as they are--use elaborate sensory mechanisms to orientate and find their way to appropriate habitats or express successful homing behavior to their natal ...Nanotech safety needs specific government risk research strategy and funding
... nanotechnology." According to Maynard's analysis, despite investing more than $1 billion annually on nanotechnology research, U.S. government spending on highly relevant nanotechnology risk research is only $11 million per year....Profiling of cancer genes may lead to better and earlier detection
...e involved in the development of lung cancer that, despite years of work in the field, I had never connected to lung cancer before," said Dr. Minna. Patient samples from UT Southwestern's new Harold C. Simmons Comprehensive Cancer Center tissue repository and previous results from study author Dr. David Eu...A simple feedback resistor switch keeps latent HIV from awakening
...tients experience short "blips" of viral activity, despite relatively low viral concentration. According to the authors, these pulses of viral activation may be due either to random increases of Tat activity or to environmental inhibitors of the SirT1 enzyme, such as dihydrocoumarin, a natural flavoring agen...HIV treatments improve health, but nutritional issues remain
...w levels of selenium or vitamins A and E. However, despite these improvements in micronutrient levels (as compared to previous studies conducted before the widespread use of HAART), Jones found that HAART users still have an increased risk for zinc deficiency. Zinc, commonly found in seafood, meat, and dairy...Winning by a neck -- Giraffes avoid competing with shorter browsers
... why giraffes feed mostly on leaves high in trees, despite being able to feed at lower levels as well. "This [study] provides the first real experimental evidence that the long neck of the giraffe might have evolved as a consequence of competition, which provides support for a previously untested textbook...Tweaking the treatment for restless legs
...his is usually not a simple, single-pill solution, despite what theyve seen on TV." In an article published in the December issue of the Journal of General Internal Medicine, Richard and fellow neurologist Roger Kurlan, M.D., warn primary care physicians that they cannot expect long-term success by simply pr...Buildup of damaged DNA in cells drives aging
... to live as long and as healthy a life as possible despite the accumulation of genetic damage as we age. Findings from this study help to reconcile two conflicting hypotheses currently favored in the field of aging research about why we get old, according to the authors. The first is that our lifespan and ...Experts advise world policies to cope with causes, rising consequences of creeping desertification
...reduction policies seldom address desertification, despite its impact on food security, and emergency drought relief treats only symptoms of desertification, not its causes. The search for successful new approaches Innovative policy options to provide the human, financial, technological and institutional...Forsyth scientists discover early key to regeneration
...nd craniofacial patterning. This study shows that despite the massive tissue proliferation required to build the tail, an early apoptotic event is required for regeneration. Normal regeneration of the tail includes a small focus of apoptotic cells; when apoptosis is inhibited during the first 24 hours, rege...Tips from the Journals of the American Society for Microbiology
...irus genus, humans are the only know reservoir and despite its eradication in1980, smallpox is currently considered to pose major risk as a biological weapon. In the study researchers used a specific probe to detect the variola virus and simultaneously differentiate it from other orthopoxviruses using a r...