Features of replication suggest viruses have common themes, vulnerabilities
... University of Wisconsin-Madison describes in fine detail how an RNA virus known as flock house virus co-opts a cell's membranes to create an intracellular lair where it can safely replicate its genes. The results provide strong evidence that at least some of the machinery four of the seven distinct class...New textbook illuminates the close links between evolutionary and molecular biology
...ided into four sections. The first three sections detail the history of evolutionary and molecular biology, describe the origin and diversification of life over the past 3.5 billion years, and explain the fundamental mechanisms underlying evolutionary change. The final section is devoted to human evolutio...Secret life of elephant seals not secret anymore!
...ecret lives of seals. The measurements reveal in detail where the seals go on their winter feeding trips, ...s, the new sensors allow researchers to examine in detail how elephant seals respond to changes in ocean conditions. Most of what we know about these seal...Developing a more effective vaccine for tuberculosis
...rol the tuberculosis pandemic is discussed in more detail in the accompanying commentary by W. Henry Boom from Case Western Reserve University....JCI table of contents: August 1, 2007
...rol the tuberculosis pandemic is discussed in more detail in the accompanying commentary by W. Henry Boom from Case Western Reserve University. TITLE: Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis AUTHOR CONTACT: Steven A. Porcelli Albert Einstein College o...New databases put wings on search for bipolar risk genes
...linical picture of bipolar disorder in the fullest detail possible, says James Potash, M.D., who led the Hopkins portion of efforts to assemble the site. It also lets us pick out meaningful clusters of symptoms that will ultimately help identify genes. Using this newer clinical subtyping approach to gene ...Gene-transcription machinery seen poised for action, held in check until needed
... illuminate the importance of the removal step and detail the resulting effects. When ubiquitin cannot be removed from the histone, the first thing seen is that a particular enzyme normally recruited into the process at the start of productive gene expression could not get in, says Anastasia Wyce, lead au...Brain's 'hearing center' may reorganize after implant of cochlear device
...d. In the future, the team hopes to determine in detail the ways in which these maps may change as a result of cochlear implants by studying subjects immediately following implant surgery....Obesity found to be a risk factor for multiple myeloma
... their findings may lead to examination in greater detail of the BMI/multiple myeloma link, including the role of IL-6 and other chemical signals, energy metabolism, and other risk factors such as weight change or weight cycling....UK scientists lift lid on genetics of coronary artery disease
...en awarded a further 7.7 million to investigate in detail the genes that have been identified already. The Wellcome Trust has also put out a call to widen its scope to study other common diseases. The researchers found that changes in our DNA on chromosomes 2, 6, 10 and 15 and two on chromosome 1 were ass...Alzheimer's prevention role discovered for prions
...next step for our research will be to look in more detail at how the prion protein controls beta amyloid, knowledge that could be used to design anti-Alzheimers drugs. Theoretically, if we can find a way of mimicking the prions function we should be able to halt the progress of Alzheimers. However, theres s...Regulating alternative splicing during neural development
...ue of G&D, Dr. Douglas Black (UCLA) and colleagues detail how alternative splicing is reprogrammed during neuronal development. Alternative splicing refers to the processing of an RNA transcript into different mRNA molecules by including some exons and excluding others. Specific cell types often have sign...Dietary calcium is better than supplements at protecting bone health
...n. The researchers asked the women to meticulously detail their diet and their calcium supplement intake for a week. "We assumed that this sample represented each woman's typical diet," says senior author Reina Armamento-Villareal, M.D., assistant professor of medicine in the Division of Bone and Mineral Di...Scientists ponder plant life on extrasolar Earthlike planets
...published in the journal Astrobiology. The papers detail the kinds of clues that researchers are looking for and explore theories of what these other worlds might be like. Blankenship is part of a NASA working group based at the Jet Propulsion Laboratory called the Virtual Plant Laboratory. He an......the order and location of base pairs determined in detail scientists can identify locations in individual mice where the jumping genes have carried pieces of loxP DNA. Then, they can select a mouse with loxP on both sides of the large piece of DNA they want to mutate and study. If the jumping gene carry...The wider view from a detailed focus
...papers published in Genome Research, defined in detail which regions of the genome are actively copied in the cell, revealed the location and studied evolution of elements that control gene activity, and defined the relationship between DNA-associated proteins and gene activity and DNA replication....Undergraduate research shows leaderless honeybee organizing
...scovery has to do with detecting a significant new detail concerning the behavior of the European honeybee perhaps the most studied and economically important insect on Earth. Beyond agriculture, the finding may also have key implications for understanding the dynamics of all social animals, including man....From the deep -- Researchers find new species of sea anemone
...dent in Daly's laboratory, describe A. pearseae in detail in a recent issue of the Journal of Natural History. The two assigned the anemone to the genus Anthosactis primarily due to the roughly uniform length of A. pearseae's tentacles a characteristic common to this group of about seven sea anemones. "W...DNA-damage test could aid drug development
...ons," Samson says. "You'll be able to look in more detail at different doses given at different times in the cell differentiation process." "This is a much cheaper assay that's at least as predictive as previous assays," emphasizes Griffith, "and drug developers can afford to use it a lot earlier in the d......ying: "Understanding the fundamental, atomic-level detail of how diseases like toxoplasmosis pick out and invade host cells in the human body is vital if we want to fight these diseases effectively. "Now that we understand that its a key interaction between a protein on the parasites surface and sugars o...