Protein transformation gives new twist to medical research
...rm, noted Sacchettini, whose group worked out the detailed molecular structure of Lyz before and after its shape-shifting. It's fascinating to know now that the same protein can exist in vastly different states. It's an academic exercise from which a lot of other interesting work and developments may d...No blind mice, thanks to UF scientists
...ery to the parts of the retina that are needed for detailed vision. Intraocular delivery of agents that block SDF-1 represent an excellent and less destructive alternative." The research sheds light on the mechanisms of diabetic retinopathy and the various functions of SDF-1, said Nadir Sheibani, an assistant...NJIT astrophysicist who revived earthshine named fellow of American Physical Society
...ysical Research Letters, Goode and a research team detailed how they had revived and modernized earthshine as a technique for monitoring Earth's climate. It is believed that earthshine's measures are a useful complement to satellite observations for determining Earth's reflectance of sunlight. Long-time obs...Research identifies promising route for treating age-related hearing loss
...nner ear," said Corey. Thus, he said, Chen began a detailed study of the hair cells of the knockout mice. Those studies revealed that the mice without Rb1 had more hair cells than normal mice, and the cells were actively proliferating. Corey and his colleagues then launched studies to determine whether the ...Desertification alters regional ecosystem climate interactions
...nd a wide range of other environmental problems to detailed analysis. I'm very excited about the potential for this work from the Department of Global Ecology to make a real difference in peoples' futures," he concluded....Mouse brain cells rapidly recover after Alzheimer's plaques are cleared
...ls to produce a dye that allowed Brendza to obtain detailed images of nerve cell branches. To correlate brain cell changes with plaque development, Brendza injected another dye, developed by scientists at the University of Pittsburgh, that temporarily sticks to amyloid. He showed that as the plaques appeared,...Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats
...s called PGC-1beta. Until now, scientists lacked a detailed explanation of how saturated and trans fats caused an increase in blood cholesterol and triglycerides, while diets high in unsaturated and polyunsaturated fats did not. Evidence pointed to the liver, which is responsible for the body's synthesis of t...Man and mouse share genome structures
In the most detailed large-scale study to date of the proteins that package DNA, researchers have mapped a family of switches that turn genes on and off. Their findings may help scientists understand regulatory mechanisms underlying cancer and human development. The res...How many comparative genomes are enough?
... Louis, describes a mathematical model that offers detailed answers to this question. "We shouldn't make these decisions based on seat-of-the-pants intuitions," Eddy said. "It's important to lay out the case that these genomes really do have tremendous value for analyzing the human genome sequence." Accordin...Discovery promises simpler therapy for sickle cell disease
...xide. Reports by the team in 2001 and 2002 further detailed nitric oxide's role in the red blood cell membrane, confirming it as the third major blood gas, along with oxygen and carbon dioxide. Those findings suggested that nitric oxide defects might play a role in the cardiovascular side effects of many diso...Rice genome approaches completion
...llenge is to use the rice sequences as a basis for detailed genetic analyses of additional cereal crops and for the development of improved strains of not only rice, but wheat, maize, and other important food crops....Compound from rare plant shows promise in treating breast cancer
...he growth of normal breast cells. The discovery is detailed in the Feb. 1, 2005 issue of the journal Cancer Research and can be found online at: www.cancerres.aacrjournals.org . "By preventing RSK from working, we completely stopped the growth of breast cancer cells but did not affect the growth of ...Experimental radar provides 3-D forest view
...n the Earth with radar signals, building up highly detailed surface images - even through clouds and local darkness out of reflected radar backscatter. In addition to simply imaging a site, two radar images of the same location acquired from close to the same position in space can be combined together using...Heart specialists call for cardiovascular screening for all young competitive athletes
...nised sport has a rigorous physical examination, a detailed investigation of their personal and family medical history and, most importantly, a 12-lead ECG. The report's writers believe that screening using ECG has the potential to cut sports-related cardiac deaths in Europe by 50%-70% if it can be implemente...New study in JAMA details trends in diagnosis, treatment of brain tumors
...ns of care are varied and there is a need for new, detailed clinical guidelines for management of brain tumors. The study is published in the Feb. 2, 2005 issue of the Journal of the American Medical Association (JAMA) found on the web at www.jama.ama-assn.org . "We have a long way to go because we sti...Gene therapy for Parkinson's disease moves forward in animals
...induced form of Parkinson's disease. The research, detailed online in the scientific publications Brain and The Journal of Neuroscience, essentially describes one strategy to halt Parkinson's disease at its onset and another strategy to treat the devastating side effects that occur when treating the disease i...New drug may be formidable adversary for hard to treat leukemia
...d in the February issue of Cancer Cell reveals how detailed information about the action of an existing drug was used to design a compound that is effective against some notoriously treatment resistant cancer cases. Despite the resounding success of anticancer drug imatinib (Gleevec) as a treatment of chronic...Open microfluidic and nanofluidic systems
...medicine, for example, they could provide fast and detailed analysis of blood samples in the physician's office without the need to wait several days before the sample has been returned from specialized laboratories. Other applications include customized chips for space travel in order to monitor microbes ins...Novel sulfide-binding mechanism found in deep-sea tubeworms
...by X-ray crystallography, providing the first such detailed structural information of a protein from a hydrothermal-vent animal. Hydrothermal-vent species must adapt to conditions of pressure and chemicals that are toxic to most other animals. While the worms are able to absorb the oxygen and sulfide through...Discovery offers cancer prevention, diagnosis, treatment hopes
...em cells, by MSU's James Trosko and colleagues, is detailed in the February issue of Carcinogenesis, one of the world's top cancer-research journals. It was already known that the oct-4 gene was located in embryonic stem cells as well as tumor cells, but researchers were uncertain whether it was expressed in ...