JCI table of contents November 1, 2004
... embryonic cell use. Landry and Zucker detail the development of laws and practices surrounding the establishmen...oteins called semaphorins could play a role in the development of tumor metastasis as they have been shown to block the migration of some cell types in culture. Mi...BU chemist to map DNA's surface, uncovering details that will show how structure abets function
... six principal investigators to receive technology development grants from NHGRI, a part of the National Institut...ta that he will use to achieve his second aim: the development of a robust, computational model for predicting cleavage patterns in any DNA sequence. Tullius pla...Research team discovers possible genetic mechanism behind congenital heart defects
... "It was previously believed that all cells during development contained the same chromatin remodelling proteins that unwind DNA, a process that is important for genes to be turned on. However, we identified one of these proteins, called Baf60c, that is expressed specifically in the developing heart," said Dr. B...Growth factors confer immortality to sperm-generating stem cells
...nfertile mice. According to the researchers, this development will have profound consequences for future fertility therapies and provide a source of stem cells that will make it possible to modify genes from males before they are passed to the next generation. While the research was performed in mice, the rese...ORNL project earns top honor from Southeast tech transfer group
...ed the research through a cooperative research and development agreement. The californium-252 was provided by DOE's Californium Industrial/University Sales/Loan Program part of the Isotope Production and Distribution Program. ...Researchers discover transport molecule that allows boron into cells
...e a strong effect of boron deficiency on embryonic development and, in adults, on bone maintenance and metabolic ...l-known signaling molecules that affect growth and development were activated when boron entered cells, and that reducing the activity of NaBC1 was sufficient to b...Cranfield collaborator receives multi million dollar financing
...ofessor Tony Turner was intimately involved in the development of this innovative product and said " The device, ...cing device, as well as the continued research and development of the company's fully-integrated glucose-testing and monitoring device. Additionally, the company ...Virginia Tech, TIGR sign memorandum for new alliance
...ecular biology. Both institutions' ground-breaking development of genomics and informatics tools for the life sci...s Institute (VBI) (www.vbi.vt.edu) said, "This new development provides an opportunity to continue to expand collaborations between VBI and TIGR, such as in the ne...Conversion of flower organs into leaves
...ast two decades. Numerous genes controlling flower development have been identified during this time. Many of the studies have focused on the small weed Arabidopsis thaliana, which possesses the typical set of flower organs--sepals (typically outer-most in the flower whorl), petals, stamens, and carpels--and hav...New source for heart bypass replacement blood vessels: Fibrin-based TEVs
...interesting questions with regards to blood vessel development and pathophysiology." Replacement of large (6-millimeter and larger) blood vessels has been successful using several synthetic materials, but smaller-diameter grafts usually failed due to thrombus or plaque formation. Various tissue-engineering appro...St. Jude named 'Research Leader' by Scientific American magazine
... the way flu vaccine is produced, reducing vaccine development time and ending the current reliance on the egg supply.The Scientific American 50 appears in the magazine's December issue, arriving on newsstands Nov. 23. The complete list may also be accessed on the magazine's Web site, www.sciam.com . Winners wi...Asymmetric organs and microRNA-directed DNA modification
...s that the regulation of critical genes that guide development of asymmetric leaf patterning depends on microRNA-...provide a general repression of PHB and PHV during development and that specific regions of the plant may have the ability to overcome this repression, thus permit...Reports says Uganda's forests worth $350 million/year
...tools that can be used to alleviate poverty. "Many development projects working with conservation assume that making people richer, by giving them alternative ways of making an income, will reduce the impact on the environment. There was good evidence that this assumption does not hold in Uganda," said Plumptre....OneWorld Health named business leader in public health on '2004 Scientific American 50'
...ases of the poorest people in the world, where the development of new medicines is clearly not profitable. By creating collaborative partnerships among industry, academia, foundations, and the nonprofit sectors, we are addressing some of the world's most devastating diseases. As a result, we can develop new me...Grants target better predictors for type 1 diabetes
...individuals with these suspect genes from birth to development of diabetes to see how the 100 genes change. A grant from the NIH's National Institute of Diabetes & Digestive & Kidney Diseases will help the MCG researchers finish analyzing the human genome. "We want to look at everything. This grant will a...First Max Planck Partner Institute in China
...t come under the term "Computational Biology". The development of theoretical methods and the modeling of systems...of processes in human organs and ultimately to the development of new medications. The Partner Institute is going to work in a number of disciplines because only t...Genetic variant linked to weakened heart pumping
...eneral may play an important role in the potential development of heart failure." Also known as congestive heart failure, heart failure is a condition characterized by the thickening of the walls of the heart. Over time this thickening restricts the heart's ability to pump enough blood to the body's tissues, and...Award will help unlock mysteries of one of Earth's most important organisms
... gas carbon dioxide from the atmosphere. With the development of new molecular tools that allow scientists to study species at the DNA level, Armbrust and her colleagues not only study individual phytoplankton, but whole communities and how they interact with their environment and respond to change. Because of ......s impact everything from basic bioresearch to drug development and clinical diagnostics. The most powerful tool for studying gene expression is the microarray, a device that uses many thousands of DNA probes to make massively parallel measurements of gene activity. But the technology is beset by large uncertaint...