New gene target found for common brain tumors in children
...ication of Notch2 is a smoking gun tying it to the development of these brain tumors," he added. In their study, the Johns Hopkins scientists compared levels of a protein marker for Notch2 gene activity to the survival of 35 medulloblastoma patients. Of 11 patients with high levels, seven died. Of 24 pat...In a tiny squid, bacterial toxin governs organ development
... tissue damage on the one hand, and critical organ development on the other - may force biologists to rethink the...ian bobtail squid, the toxin was found to spur the development of a structure, a light-producing organ that acts as a sort of "Klingon cloaking device," mimicking ...Rethinking new therapies for Crohn's disease at U.Va.
...esponse to infection- may have more to do with the development of Crohn's than acquired immunity, currently thought by many to be the most likely suspect. Patients, physicians and medical researchers need to reconsider traditional hypotheses about the biological processes that underlie Crohn's disease, acc...Reduced fish stocks linked to increased bushmeat trade, wildlife declines in W. Africa
...ople near parks and say the solution lies in local development projects for local people," Arcese says. "It's an ...sources, including marine fishes, then small-scale development projects that sometimes encourage the reliance of local people on wildlife harvest are unlikely to h...Investigating the Columbia River and Estuary: A primary focus of research
...ter. The study addresses survival, differences in development and growth from eyed-egg stage to swim-up stage. The presentations will be conducted in Rooms B113 and B114, Portland Convention Center between 8:00 a.m. and 12:00 noon on November 18. Details regarding the Fourth SETAC World Congress event are ava...Denmark makes national Open Access commitment
...inate research but also represent a completely new development in journal publishing. A national agreement like this benefits all scholars and research institutions in Denmark, including smaller research projects in growth areas." Natasha Robshaw, Head of Marketing and Sales at BioMed Central, said: "We applaud ...Academy eBriefings offer comprehensive reports on more than 100 cutting-edge scientific issues
...ng new drugs. How scientists are accelerating the development of an AIDS vaccine. Understanding leukocytes and their role in fighting disease. How new cancer therapies are utilizing genomic data and microarray technology. Since July 2003, with its inaugural eBriefing on promising new drugs for autism, the Aca...Scientists advocate genomic sequencing of 'living fossil'
...ne cluster. Encoding for proteins involved in the development and maturation of neurons and synapses in the brain, protocadherin clusters are not present in invertebrates, such as fruit fly (Drosophila melanogaster) or roundworm (Caenorhabditis elegans), but they are found in more evolutionarily complex species...Yale environmental journal translated into Chinese
...my and most populous country in the world, China's development plays a crucial role in the future of the global environment. "This project is especially timely because the Chinese government has announced the 'circular economy' (xun huan jing ji) as a centerpiece of Chinese environmental policy," said Lifset....New findings may redirect strategies for treatment of prostate cancer
...s a major physiological role in normal male sexual development and contributes to the progression of prostate cancer. About one-third of prostate cancer patients develop metastatic disease and receive treatment to block androgen production and the AR itself. Unfortunately, although this treatment may work for so...Discovery reveals how the body regulates blood oxygen
...aid Professor Kemp. "It will certainly lead to the development of new therapeutic strategies aimed at maximising oxygen delivery when and where it is needed most." The scientists have identified an oxygen-sensing protein, which in mammals is located in a cluster of cells at the spot where the carotid artery bran...UCSD discovery opens new avenues for design of anti-tumor medications
...low oxygen is a viable alternative strategy to the development of angiogenesis inhibitors. Furthermore, the researchers point out that it may be easier to design effective treatments that target the endothelial cells rather than the tumor cells. "Cancer cells mutate frequently," says Nan Tang, a graduate ...Nuclear imaging offers possibility for early detection of patients with coronary heart disease
...information about plaque composition and drive the development of more informative imaging techniques, they say. "Nuclear imaging has the potential to provide invaluable information on the cellular, metabolic and molecular composition of the plaque," note the authors. In the journal's invited perspective, "Non...GlaxoSmithKline awards $250,000 in research grants for research on drug therapies for HIV/AIDS
... 2001, GSK has awarded $1.5 million to further the development of inventive treatments for HIV/AIDS. These include therapies designed to prevent HIV infection or prevent transmission of the virus from one human to another. Applicants interested in more information about the Drug Discovery and Devel...JCI table of contents, November 15 2004
...he absence of CD3 epsilon completely blocks T cell development at a specific stage in the thymus. In an accom...tal triggers. T2DM is caused by the development of insulin resistance in muscle and liver coupled with the progressive failure of beta cells in the ...Researchers piece together the puzzle of Hailey-Hailey skin disease
...k. These lines are thought to trace the pathway of development of the ectoderm, one of the three layers of cells ...anding of gene mosaicism as well as of embryologic development of the ectoderm." This study will prompt further examination of the mechanisms of embryologic develo...Inactive form of scatter factor protein found to suppress tumor growth and spread
...able pro-SF at the site of the tumor prevented the development of new blood vessels to the tumor, tumor growth, a...F is an important step in the progression of tumor development and also suggests that drugs that inhibit this cleavage may lead to successful anti-cancer therapies...Aging affects susceptibility to type 2 diabetes
...t of environmental triggers. T2DM is caused by the development of insulin resistance in muscle and liver coupled ...ic and environmental influences such as age on the development of insulin resistance and T2DM. The finding that the age-dependent decrease in expression of thes...New gene mutation found to cause 'bubble boy disease'
...he absence of CD3 epsilon completely blocks T cell development at a specific stage in the thymus. ......or gene for destruction may be a key player in the development of lung cancer. Writing in the Nov. 17 issue of th...lleagues identified the link between Pirh2 and the development of cancer by evaluating Pirh2 expression in human and mouse lung tumor samples and comparing it with...