Spleen may be source of versatile stem cells
... address the autoimmune reaction underlying type 1 diabetes actually cured the disease in diabetic mice. Late in 2003 they reported the mechanism behind the earlier discovery: cells from the spleens of donor mice intended to train the diabetic animals' immune systems not to attack islet cells were actually...Protein adiponectin appears protective against heart disease
... focus on risk of the disorder among patients with diabetes mellitus type 1, previously known as juvenile diab...in specific to fat tissue, is involved in obesity, diabetes and heart disease. Results of the study are published in the January issue of Diabetologia, a leadin...Plant protein mimics hormone that mitigates diabetes and obesity
...uld play a role in the prevention of diseases like diabetes as well, because it has the same target as adipone... and, in mouse models, prevents the development of diabetes and atherosclerosis, or the hardening of the arteries associated with heart disease. Previous studie...Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats
...ic research on fat cells and metabolic pathways in diabetes and cancer at Dana-Farber. "It offers the opportunity to try to understand what makes these fatty acids so deleterious, and what we need to avoid." Moreover, it is possible that in the future, drug therapy might be used to "turn down" the mechanism, ...Pro-inflammatory enzyme linked to diabetes; Immune system's macrophages may be key to treatment
...linked to insulin resistance and resulting type II diabetes by researchers at the University of California, Sa...me in the immune system's macrophages may be a new diabetes therapy. Published in the February 2005 issue of the journal Nature Medicine, the study describes re...Discovery promises simpler therapy for sickle cell disease
...oxygen delivery to tissues, such as heart failure, diabetes and pulmonary hypertension. Collaborators on the study include lead author John Pawloski and Douglas Hess. The work was supported by the National Institutes of Health and a Doris Duke Clinical Scientist Development Award.......sulin in response to glucose Patients with type 2 diabetes have impaired insulin secretion in response to glucose. Normally, insulin is stored in vesicles inside pancreatic b cells and upon vesicle transportation to the cell surface and membrane fusion, their insulin content is released. The mechanism used ...Multi-purpose protein regulates new protein synthesis and immune cell development
...which could be helpful in autoimmune diseases like diabetes and lupus."...Opposing fat metabolism pathways triggered by a single gene
... for treatment of fat metabolism disorders such as diabetes and obesity....International HapMap consortium expands mapping effort
...elated to common diseases, such as asthma, cancer, diabetes and heart disease. When the project was launched ...an another. For any given disease, such as type II diabetes or coronary artery disease, researchers can use the HapMap to compare the genetic variation patterns...PCRM develops world's first cruelty-free insulin assay
... had two options available to us when we began our diabetes trials," said Dr. Barnard. "One, we could use test kits with insulin antibodies grown in vivo--literally from cells injected into the abdomens of live mice--or we could use kits containing antibodies produced from cells cultured with fetal calf serum...JCI Table of Contents, March 1, 2005
...ent.shtml Removing IRS: good for taxes, bad for diabetes Insulin resistance in the liver contributes to th...has a direct causative role in the pathogenesis of diabetes and is not merely a correlative observation. TITLE: Complementary roles of IRS-1 and IRS-2 in the h...Joslin scientists show knocking out two key signals will cause diabetes
...ifferent metabolic abnormalities present in type 2 diabetes can be caused by knocking out two key signals in l...cells, we began to uncover just how complex type 2 diabetes and the related metabolic syndrome are," said principal investigator C. Ronald Kahn, M.D., President...Proteins link obesity, diabetes; May underlie systemic 'metabolic syndrome'
...tend to go along with the excess weight, including diabetes and fatty liver disease, suggests a new study published in Cell Metabolism. The constellation of obesity and its related symptoms, commonly referred to as metabolic syndrome, is estimated to affect more than one out of every five adults in the U.S. D...Diabetes' link to obesity broken in mice
...ce to uncover a potentially important link between diabetes and obesity. By genetically altering production of...ed insulin sensitivity, which is a primary goal of diabetes treatment. "These results confirm that the links between obesity and diabetes show great promise a...American Chemical Society meeting March 13-17 features wide variety of new research
...il to introducing a new method for fighting Type 2 diabetes and lowering cholesterol, chemists will present th...resistance problem Discovery of a gene for Type I diabetes Examining labels on food and beverage containers: do they tell the whole story? New wood preservat...2005's highest engineering honors awarded
...od. Today many of the 18.2 million Americans with diabetes rely on Clark's original glucose sensor concept for self-monitoring. In the future, an implantable biosensor -- newly patented by Clark -- could make blood glucose monitoring even easier by sending readings whenever needed. The Clark oxygen electro...Probable trigger of kidney disease in diabetics identified
...e. However, scientists do not fully understand how diabetes damages the kidneys. Erwin Bttinger, MD, Professor...s of kidneys from humans and mice with and without diabetes and looked at the effects of high glucose concentrations on the cells in the kidneys. They found tha...Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
... weight have a high potential of developing type 2 diabetes later in life. In studies of mice, the researchers...500 mg/dl -- the equivalent of serious, full-blown diabetes in humans," Dr. Patti said. In type 1 diabetes, the pancreas cannot make the hormone insulin at all;...... common, complex illnesses such as heart diseases, diabetes and cancer. Building a catalog of rat SNPs will assist researchers trying to find genetic variations associated with common, complex diseases in rats, which can then be used to help identify similar genetic variations that may be involved in human di...