Secrets of the cilia: Kidney disease and blindness share common genetic defect
...ay play an important role in diseases ranging from diabetes to Alzheimer's. News of the discovery is published...phronophthisis with retinitis pigmentosa, but also diabetes mellitus, obesity, infertility and mental retardation," says Hildebrandt. "Scientists studying this ...Future diabetes drugs may target new protein interaction
...ork. Sirtuin1's potential as a target for treating diabetes is much closer, says Puigserver. The researchers are now probing the pyruvate-sirtuin1 connection more closely and looking for more details of the sirtuin1-PGC1 interaction. Also on the to-do list: examining sirtuin1 and PGC1 in other tissues, partic...JCI table of contents April 1, 2005
... Major information on MODY mutation Mature onset diabetes of the young (MODY) is an inherited form of diabetes that can result from mutations in many different genes, including HNF-4alpha. HNF-4alpha is express...Consortium to create comprehensive tools for uncovering the functions of human, mouse genes
... normal physiology and diseases including cancer, diabetes and immunological responses. TRC will not only create and validate these reagents, but will make them available to scientists worldwide through commercial and academic distributors. TRC is based on a scientific collaboration among principal investiga...Leptin: A 'missing link' between obesity and diabetes?
...BOR, Mich. -- Twin epidemics of obesity and type 2 diabetes are bearing down on the world's population, threat...hem understand why some obese people never develop diabetes while many others do. The study, published in Cell Metabolism, suggests that the hormone leptin regu...Institute for Medical Research scientists identify gene critical to type 1 diabetes
...evelopment of type 1 diabetes. This is the type of diabetes that typically arises in childhood, requires insul...r. Al-Abed that blocked MIF and the development of diabetes in laboratory experiments. When injected into mice treated with a chemical known to induce a form of...Chemists identify key gene in development of type 1 diabetes
...ked the gene for the MIF protein failed to develop diabetes compared to mice that possessed the gene, accordin...the researchers reported they were able to prevent diabetes in a group of mice by using a synthetic compound called ISO-1 to block the MIF protein. If human stu...Joslin Diabetes Center scientists find genetic defects
...eta cells." This first step in the onset of type 1 diabetes is called insulitis. Later in life, within weeks or even years, full-blown type 1 diabetes emerges. An estimated 1 million people in the United States have type 1 diabetes. Their pancreatic ...NJIT Presidential Award winner takes stem cell research another step
...pport the team's research. "People suffering from diabetes have impaired bone healing," Arinzeh said. "So the question is how to treat patients suffering from bone fractures and other defects that may not heal because they are also suffering from other disorders. We are looking at the current treatment for r...Highly adaptable genome in gut bacterium key to intestinal health
...n to obesity and obesity-related disorders such as diabetes and heart disease The bacterium of the study, called Bacteriodes thetaiotaomicron or B. theta, is among the most abundant species in the human gut microbial community. B. theta breaks down otherwise indigestible carbohydrates, such as dietary fiber, ...UT Southwestern researchers uncover gene variant that appears to predict type 2 diabetes
...variant that could serve as a predictor for type 2 diabetes has been identified by researchers at UT Southwest...ch as 13 percent more common in people with type 2 diabetes and those at greater risk for the disease. While further studies are needed, researchers said these ...Sea skate experiment sheds light on human cell transport
...ings could explain the problem. People with type 1 diabetes don't produce insulin. Without that hormone, vesicles aren't inserted into cell membranes and glucose can't be moved between cells. And when channels are blocked, damaged cells can't die. This cell "suicide" is one of the body's defenses against can...JCI table of contents May 1, 2005
...lasting drugs really work The incidence of type 2 diabetes (T2D) is increasing around the world. It is assoc... on lipoprotein metabolism in patients with type 2 diabetes mellitus AUTHOR CONTACT: Henry N. Ginsberg Columbia University, New York, NY USA Phone: (212) 305-9...JCI table of contents April 1, 2005
...SEASE Sifting through the cells responsible for diabetes Insulin receptor substrate 2 (IRS2) plays a role...don sought to further understand the generation of diabetes and the role of IRS2 in brain cells and the pancreatic cells that produce insulin. The authors have...NASH clinical research network launches new trial for treatment of liver disease
...sults from small pilot trials suggest that certain diabetes drugs improve liver enzyme levels and may slow or reverse the progression of NASH. Other pilot studies indicate that patients with this liver disease show improvement by following a regimen of balanced diet and exercise and also respond favorably to ...Pediatric burn victims' recovery, diabetes, metabolism aided by fenofibrate (Tricor)
...healthy children. We wanted to understand why this diabetes develops and to see if medication could reduce it," Cree said. The study involved 18 child burn victims ages 4 to 14 years of age who were admitted within four days of injury to the Shriners tertiary burn center in Galveston. They were studied four ...14 highlighted physiology papers from IUPS 2005: From 'genomics to functions'
...al Branch and Shriners Hospital for Children. With diabetes a common reaction to trauma and surgery, directly treating insulin resistance could speed recovery. The researchers found that a surprising 70% of victims 4 to 14 with over 40% surface burns suffered insulin sensitivity about half of healthy children...Altering steroid receptor genes creates fat burning muscle
...scle strength, combat obesity, and protect against diabetes in these patients....Joslin Diabetes Center announces new nutrition guidelines
... physical activity is directly related to improved diabetes control. To help Americans fight the dramatic incr...s for overweight and obese individuals with type 2 diabetes and those at risk for developing diabetes (pre-diabetes). "Since obesity doesn't seem to be slowing......ids and triglycerides, may alter susceptibility to diabetes and atherosclerosis. TITLE: CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood AUTHOR CONTACT: Nada A. Abumrad Washington University, St. Louis, MO USA Phone: (314) 747-0348; Fax: (314) 444-3432; E-mail...