Malfunctioning bone marrow cells sabotage nerve cells in diabetes
... ago, when we were developing gene therapy to cure diabetes in mice. By chance, we observed insulin-producing bone marrow cells outside the pancreas, and wondered why these cells were migrating to other organs and whether they were detrimental or beneficial," said Chan. In pursuit of this curious phenomenon, ...Studies find possible drug targets for improving vascular health
...ral vascular disease secondary to atherosclerosis, diabetes or aging. The studies in PNAS and JCI are synergistic since Akt can regulate nitric oxide synthase function by increasing its activity....Yerkes to develop first transgenic nonhuman primate model for inherited neurodegenerative diseases
...ate models of human diseases, such as Alzheimer's, diabetes and heart disease, that will offer more opportunities to test new drugs, gene therapy and modified stem cells....JCI table of contents September 1, 2005
...fficient for diabetic atherosclerosis People with diabetes are more likely to develop atherosclerosis, leading to more heart attacks and strokes in this population. But evidence that hyperglycemia in these patients contributes to atherosclerosis was lacking. In a study appearing online on August 25 in advan...One shot: A molecular movie of events that enable sperm to penetrate egg's coating
...in-producing beta cells of the pancreas to prevent diabetes or to get neurotransmitters released in the brain at the right time or concentration," Mayorga pointed out. "Those are all examples of regulated exocytosis, and AE is a simple model they can use."...Soy protein reduces effects of diabetes on liver
...s of insulin and insulin-resistance that accompany diabetes are often associated with fatty liver or hepatic steatosis, an untreatable condition that can lead to chronic liver disease and death. In this condition, large lipid-filled compartments accumulate in the cells of the liver due to an increase in produ...Key regulator of blood glucose levels discovered
... new target for the development of highly specific diabetes drugs that signal the liver to reduce the production of sugar. The Salk researchers, led by Marc Montminy, a professor in the Clayton Foundation Laboratories for Peptide Biology, published their findings in the Sept. 7th online issue of Nature. "It i...UCSD study of nuclear receptors could change anti-inflammatory treatments
...ative side effects, including high blood pressure, diabetes and obesity. "What is of particular interest in this study," said Glass, "is that adding two drugs together could have a much more substantial interaction while using much less of each drug. This could result in much better therapeutic results with ...Researchers gain support from Merck Sharp & Dohme for novel area of diabetes research
...cing treatment, and possibly developing a cure for diabetes since beta-cell dysfunction is a major factor cont...rd comments, "Despite its great potential European diabetes research suffers from under-funding both at European Commission and national levels. This partnersh...Sitagliptin, a new investigational treatment for type 2 diabetes, may offer new hope for patients
...re are currently more than 194 million people with diabetes worldwide and this figure could exceed 333 million...25 if untreated. [2] Current treatments for type 2 diabetes are often limited by their side effect profile, route of administration or difficulties in sustainin...First link found between obesity, inflammation and vascular disease
...covered that resistin, the hormone associated with diabetes and insulin resistance, can stimulate production of CRP proteins. "And this is interesting because it is known that resistin is itself produced by fat cells," Yeh said. "We know that patients with metabolic syndromes have higher levels of CRPs, as w...Protein structure key for AIDS, cell function
...lved in certain diseases, ranging from leukemia to diabetes and HIV-AIDS. Levels of the protein climb, for reasons unknown, when people fall ill, making human CD38 a marker for these diseases. As one example, researchers have shown that CD38 interrupts an interaction between the AIDS virus and its point of...JCI table of contents October 1, 2005
...ED ROLE FOR ENZYME IN AUTOIMMUNE DIABETES Type 1 diabetes is an autoimmune disease characterized by destruct...yme that is required for the development of type 1 diabetes in the NOD mouse model. This data shows that lysosomal proteases may contribute to the homeostasis ...Human beta-cell line offers hope for type 1 diabetes breakthrough
...an alternative to beta-cells from cadavers. Type 1 diabetes results from the loss of insulin-producing beta-cells in the pancreas. Because the supply of beta-cells from cadavers is insufficient to meet the needs of 99% of diabetic patients, alternative sources of beta-cells would be highly desirable. Previous...Seaweed could make junk food healthier
...eapon in the international battle against obesity, diabetes and heart disease and diseases such as bowel cancer. The research paper examines the properties of a brown-coloured seaweed called Lessonia and Laminaria, found in the Far East, South America and parts of Norway and Scotland. The seaweed is processed...Sept/Oct 2005 Annals of Family Medicine tip sheet
... with a family history of cancer, heart disease or diabetes finds that a patient's understanding of their fami...metformin, a drug used for the treatment of type 2 diabetes and polycystic ovary syndrome, as treatment of overweight or obese adults who do not have diabetes o...Fruit fly studies open new window on cancer research
...ing our understanding of processes associated with diabetes as well as cancer. We're fortunate that there are a number of groups with clinical interests in these areas in close proximity to us, which should help us assess the medical significance of our discovery." Fruit flies are used in research because a ...U-Michigan receives $18.7M for National Center for Integrative Biomedical Informatics
...cal problems prostate cancer, bipolar depression, diabetes type I and diabetes type II. Researchers need new tools to understand the genetic, metabolic and clinical heterogeneity ...Free-energy theory borne out in large-scale protein folding
...y but mysterious role in Alzheimer's, Parkinson's, diabetes and a host of other diseases, so mapping the normal route a protein takes and finding the off-ramps that might lead to misfolding are vitally important," Wittung-Stafshede said. Rice's studies were carried out on monomeric lactose repressor protein...Joslin study sheds light on birth defect cause in pregnant women with diabetes
BOSTON The babies of women with diabetes are two to five times more likely to develop birth...the more we know about the effects of the mother's diabetes on the embryo, the more tools we have to identify therapies that may prevent birth defects in diabet...