September/October 2004 Annals of Family Medicine tip sheet
...ecorded an average of 3.88 problems per visit; for diabetic patients, they recorded an average of 4.6. The authors posit that these findings suggest a mismatch between family medicine and current approaches to quality assessment, guideline implementation, education, research, administration and funding. Futur...Gene therapy approach reverses diabetic neuropathy in animal model, Pitt study finds
...d for the first time that gene therapy can reverse diabetic neuropathy. While their studies have so far only i... nerves. Five weeks after a one-time inoculation, diabetic animals receiving gene therapy had complete reversal of established peripheral neuropathy and restor...Diabetic damage to eyes, heart, nerves, kidneys may be explained by controversial theory
...butor to non-traumatic lower limb amputations, and diabetic kidney damage creates 43 percent of all cases of e...r scientists long ago rejected as a contributor to diabetic side effects. The researchers address the many objections and questions raised by critics of their h...Fat buildup found in hearts of obese or diabetic heart failure patients
...iling hearts were four times the level in obese or diabetic patients as they were in non-failing hearts. The research team associated this buildup of triglycerides in the heart muscle, called lipotoxicity, with dysfunctional expression of genes related to the heart's metabolism of fatty acids, its contract...Cranfield collaborator receives multi million dollar financing
.... This is an especially important breakthrough for diabetic children, who often have very sensitive skin." Proceeds from this financing will be primarily used to support Pelikan's commercialisation of the FDA-cleared Pelikan Sun TM lancing device, as well as the continued research and development of the comp...Grants target better predictors for type 1 diabetes
...ime, you can think that someone who is going to be diabetic will be high for one protein, low for another and maybe moderate for the third. Maybe someone who is not going to develop diabetes will have a different combination. So if you were to plot that in three-dimensional space, you can look at different sp...U. Va. Health System to develop new approaches to treat type 1 diabetics with islet cell transplants
...oming back after islet cells are transplanted into diabetic mice. "Lisofylline shows some benefit in human islet cell function, and it is time to test this drug in clinical islet transplantation," Yang said....Study shows stem cells can preserve vision
...ts for people suffering from macular degeneration, diabetic retinopathy and other retinal diseases," says Michael Young, PhD, an assistant scientist at Schepens Eye Research Institute and the lead author of the study. The retina is a tissue-thin membrane at the back of the eye responsible for sending light an......reatly from the same vitamin. About 40 percent of diabetic patients can reduce their risk of heart attacks an...th and heart attack in a significant proportion of diabetic patients," he said. Dr. Levy had demonstrated in multiple previous studies that haptoglobin 2...JCI table of contents, December 15 2004
... Diabetes-associated nerve fiber damage, known as diabetic neuropathy, can result in a decreased ability of a...are increased at the sites of peripheral nerves in diabetic patients. AGE was shown to induce increased and sustained activation of NF-kappaB, which is closely...No blind mice, thanks to UF scientists
... a condition similar to one that robs thousands of diabetic Americans of their eyesight each year. Writing in ...e eyeballs of 46 patients undergoing treatment for diabetic eye disease, including 24 patients with retinopathy. They found SDF-1 in each of the patients, with ...Spleen may be source of versatile stem cells
...ying type 1 diabetes actually cured the disease in diabetic mice. Late in 2003 they reported the mechanism be...m the spleens of donor mice intended to train the diabetic animals' immune systems not to attack islet cells were actually producing new islets. The result ...Combating blindness is vision of UT, ORNL project
...sis and treatment of blinding eye diseases such as diabetic retinopathy, glaucoma and age-related macular degeneration," said project co-leader Ken Tobin of ORNL's Engineering Science & Technology Division. Diabetic retinopathy alone will affect 239 million people worldwide by 2010, according to Tobin, who no...Joslin scientists show knocking out two key signals will cause diabetes
...be knocked out at the same time to create the full diabetic syndrome, while depleting just one or the other caused only either the glucose or the lipid abnormalities associated with diabetes. Thus, these two pathways complement each other, each controlling a part of the metabolism that is disrupted in type 2 ...Diabetes' link to obesity broken in mice
...s unusually active in heart and skeletal muscle of diabetic mice. PPAR-alpha normally becomes active in response to fats. It "revs up" the machinery cells use to make energy from fat, according to Kelly. "It's an adaptive response that helps the cell deal with all the fat that's coming in, but our notion wa...Spit, and call me in the morning
...could compare it with the salivary proteome of the diabetic population or breast cancer population, for example," Wong said. Wong and his colleagues recently reported in the journal Clinical Cancer Research that RNA molecules in saliva can indicate whether a patient has head and neck cancers, which he said i...Probable trigger of kidney disease in diabetics identified
...ied a protein that might trigger kidney disease in diabetic patients, a condition that affects one in three pe...as possible. Kidney disease in diabetics, known as diabetic nephropathy is the leading cause of kidney failure worldwide. It is known that this disease occurs m...Pioneering PET/CT research widens applications of imaging for diabetic foot
...te detection and localization of foot infection in diabetic patients, according to an article in the March issue of the Journal of Nuclear Medicine. PET/CT scans could potentially offer a single-step, noninvasive technique for the diagnosis of infection, said Society of Nuclear Medicine member Zohar Keidar, M...APS announces 2005 Young Investigators Awards
...e ion channels in certain kidney diseases, such as diabetic and polycystic kidney disease. David L. Allen, Ph.D. University of Colorado, Boulder The Shih-Chun Wang Young Investigators Award This $7,000 award recognizes an individual with outstanding promise in the field of physiological research. Dr...Chemists identify key gene in development of type 1 diabetes
...hat they showed in previous studies is elevated in diabetic animals and may be involved in the cascade of immu...ease when it is diagnosed in the early stage. Most diabetic children are identified when the disease still in the early stage suggesting that there is room for ...