JCI table of contents, November 15 2004
...ew structure described for kidney filter: the slit diaphragm One of the main functions of the kidney is the f...he size-selective kidney filter, known as the slit diaphragm (SD), prevents plasma proteins from leaking into the urine. This filtration barrier consists of laye...Gene mutation responsible for lung and diaphragm defects
...ally, people need more than just healthy lungs. A diaphragm - the large muscle that creates a vacuum to draw a...use Fog2 gene can cause small lungs and abnormal diaphragm development. Could the same gene be involved in human diaphragmatic defects? After studying childr...Cells from amniotic fluid used to tissue-engineer a new trachea
...nital diaphragmatic hernia (CDH), or a hole in the diaphragm that separates the lungs from the visceral organs. If the hole is large enough, the stomach and other visceral organs can end up in the chest cavity, crowding the lungs and stunting their growth. Using mesenchymal stem cells from amniotic fluid, Fau...Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy
... had been systemically incorporated into skeletal, diaphragm and cardiac muscle cells in both groups. More importantly, cardiac and lung muscle cells in both newborn- and adult-treated hamsters were able to express the normal protein almost a year later. There were dramatic biochemical and structural improveme...Robo-rodent gets 'touchy-feely'
...ct or surface, the whisker deformed the microphone diaphragm in a measurable way, allowing researchers to track characteristic signals from particular surfaces. The researchers then experimented with various whisker arrays and designs, to discover the optimal profile. Even more exciting, however, were the resu...New Georgia Tech probe revolutionizes nano imaging
...ulled by attractive forces. Much like a microphone diaphragm picks up sound vibrations, the FIRAT membrane starts taking sensory readings well before it touches the sample. And when the tip hits the surface, the elasticity and stiffness of the surface determines how hard the material pushes back against the ti...Researchers discover botulism toxin's insidious route into nerve cells
...e it can kill people by paralyzing motor nerves in diaphragm muscles, causing breathing to stop. Lack of knowledge about the identity of the cell surface receptor that botulism toxin A uses to invade nerve cells has hindered the development of new antidotes to the toxin. "People thought that since these were t...Genomatix technology facilitates de novo identification of new renal disease associated genes
...fectively predicted a previously unrecognized slit diaphragm molecule which was then experimentally verified. This publication shows a straightforward approach how comparative promoter analysis can identify regulatory pathways at work in tissue homeostasis and disease processes....Phase III trials of cellulose sulfate microbicide for HIV prevention closed
... in men -- 2 Other (safety of CS when used with a diaphragm and MRI imaging)- 2 Contraceptive effectiveness studies - 2 Most of the trials were undertaken in the United States (7), one was done in Europe, and three in countries where the HIV prevention trials were expected to be carried out. The contra......ped cancer in the lung and several sites below the diaphragm (areas exposed during radiation treatment for testicular cancer) had poorer survival than patients whose first cancers were in the same area. Treatment regimens for testicular cancer used since 1980 have not adversely affected survival from subsequ...