UCLA scientists produce functioning neurons from human embryonic stem cells
...ns that are found in the forebrain. The other line differentiated into neurons found in rear portions of the brain a..., is a forebrain disease, so the neurons should be differentiated from a cell line that is biased to produce neurons from the forebrain. Sun said there are ways to...Not all embryonic stem cell lines are created equal
... their colleagues found that the two ES cell lines differentiated into two distinct types of neurons that are actually found in different parts of the brain. The researchers next performed electrophysiological studies of the synaptic connections between the neurons. We found that the neurons derived from the two ce...Cardiac patches stimulate regeneration, improve function after heart attack
...logy in March. This finding supports the idea that differentiated cardiomyocytes can proliferate. Using a small patch fashioned from a sponge-like material called Gelfoam, they then moved to experiments in rats with induced heart attacks. In half the rats, a patch that had been incubated with periostin was placed...A twist of fate -- Reprogrammed fibroblasts resemble embryonic stem cells
...to find a way to reliably reprogram an individuals differentiated tissue cells into cells that behave like embryonic...ctivation of the X chromosome that was silenced in differentiated cells and exhibited random X inactivation upon differentiation. Our results demonstrate that the e...Soy estrogens and breast cancer: Researcher offers overview
...e puberty causes mammary gland differentiation. "A differentiated cell undergoes less proliferation and therefore is less likely to progress through the cancer process," he said. "However, if the estrogen is administered to an animal after the development of an estrogen-responsive tumor, the growth of this tumor wi...Joint research on poverty-related diseases
...projects, the DFG would like to make an effective, differentiated contribution to the organisation and expansion of research capacities on the African partner side. In this programme, which should run for a maximum of eight years, the DFG will also provide funding for the cooperation partners of German applicants....Stem cell identity in culture may strongly depend on the cellular microenvironment
..., perhaps, even to develop stem cells from already differentiated cells instead of using embryos....Nanotechnology offers hope for treating spinal cord injuries, diabetes and Parkinson's disease
...xample saving damaged cells or regenerating needed differentiated cells from stem cells. This same work also has implications for Parkinsons and Alzheimers, both diseases in which key brain cells stop working properly. During his presentation, Dr. Stupp allowed a rare glimpse into ongoing research with col...Discoveries thrust cancer-initiating stem cells into a larger role in cancer biology and treatment
...uman colon cancer cells for molecular markers that differentiated some cells from others. They found a certain subset of cells produced an exceptional amount of CD44 cell surface receptor protein, a well-studied protein involved in many forms of cancer. According to Chu, to be identified as cancer stem cells,...Mouse model advances understanding of synovial sarcoma
...with embryonic lethality, while expression in more differentiated muscle cells induced significant muscle cell damage and death in the absence of tumor formation. Further studies demonstrated that this mouse model of synovial sarcoma faithfully recapitulates human synovial sarcoma on multiple levels. As in the ...... hers and the difference is genetic. Species with differentiated sex chromosomes (X and Y in humans, for example) get around the fact that males and females get different-sized portions of sex chromosome genes with a balancing act geneticists call dosage compensation. But research published today in the Journal o...Chemical cues turn embryonic stem cells into cerebellar neurons
...mplanted in the brain appear to develop into fully differentiated granule neurons, the most plentiful neuron in the ...mplanted in the brain appear to develop into fully differentiated granule neurons, the most plentiful neurons in the cerebellum. The cerebellum, which is tucked int...Major gene study uncovers secrets of leukemia
...tioning lymphocytes. Normally, the body eliminates differentiated B lymphocytes that have failed to assemble the right genes to make effective antibodies against the specific target they are supposed to attack. However, if these defective B lymphocytes do not differentiate because of the mutations, the body will no...Sphingolipids with therapeutic ends
...ter 4 or 5 days in culture, the macrophages became differentiated and were prepared for their study. So, for the death of these cells to be induced, they are incubated removing the cytoquine needed for growth from the culture and, thus, the cells enter into apoptosis. In the same way, adding different sphingolipi...Treating male infertility with stem cells
...ting that the stem cells had differentiated. These differentiated donor (green) cells were also found near the nativ...ssed marker proteins known to be found only on the differentiated cells, not on stem cells. These data demonstrate that bone marrow stem cells have the potential t...Scientists clone mice from adult skin stem cells
...iciency of adult skin stem cells with that of more differentiated skin cells and also with cumulus cells the cells that surround a developing oocyte and have traditionally been the preferred cell type for nuclear transfer. The stem cells gave the best efficiency, yielding 19 pups, nine of which grew up into normal...Scientists identify pancreatic cancer stem cells
... stem cells in organs that have mutated, or from a differentiated cell that has devolved to take on the qualities of stem cells. They are resistant to traditional therapy designed for cells that rapidly turn over because stem cells don't, according to some researchers. Thus, they remain after tumors shrink and may ...ACS News Service Weekly PressPac -- January 10, 2007
...tors keep them eternal and which destine them to a differentiated fate" "Getting to the Root of Cancer: The dark side of stem cells is initiating a revolution in cancer research" "Claims Under Fire: The future of embryonic stem cell research in the U.S. may hinge on current review of key patents" "Reducing A...Synthetic peptide targets latent papilloma virus infections
...mids turn into infectious viruses only in the top, differentiated layers of tissue. Previous work showed that the bovine papilloma virus hitchhikes by throwing out a thumb - in actuality, a protein called E2 - that latches onto a cellular protein that, in turn, attaches to histone proteins that envelop the chromos...CAMBRIDGE, Mass.-Stem cells grew, multiplied and differentiated into brain cells on a new three-dimensional scaffold of tiny protein fragments designed to be more like a living body than any other cell culture system. An MIT engineer and Italian colleagues will report the invention-which may one day replace the u...