UT-Houston scientists develop new procedure to differentiate human embryonic stem cells
...at Houston have developed a new procedure for the differentiation of human embryonic stem cells, with which they hav...dure which facilitates, via genetic selection, the differentiation of human embryonic stem cells into an essentially pure population of lung epithelial cells, said Wet...MIT bioengineer advances survival, promise of adult stem cells
...tor known as EGF, which plays a role in growth and differentiation of many cells, including stem cells. However, its ability to protect stem cells against the sort of pro-death signals found at the implant site was previously unknown. When EGF attaches to receptors on the stem cell surface, it activates many pathw...Treating male infertility with stem cells
...nfertility may arise from failed proliferation and differentiation of the germ cells (precursors of sperm) or from dy...onor stem cells. As further confirmation of the differentiation status of the donor cells, the expression of specific proteins on the cell surface was examined. Bot......n controlling the synthesis of testosterone and in differentiation of germ cells in mouse testes. This work, publish...e alterations programmed from the moment of sexual differentiation in the embryo and ftus. It is characterized by anatomical alterations: the maturation of primary se...Researchers discover gene essencial to cerebellum formation
...al nerve cells (or stem cells) and their selective differentiation into 'gabergic' neurons, or cells that contain the...protein Ptf1a/p48 is needed for the production and differentiation of Purkinje neurons, the most important cells in the cerebellum"; and second, "that in the absence o...Major gene study uncovers secrets of leukemia
...e so-called "master genes" that control the normal differentiation of immature progenitor cells into mature B lymphoc...ound in other genes with important roles in B-cell differentiation including "EBF1" and "Ikaros." "Although the identification of such a high frequency of mutations...CIRM awards $6M to Burnham Institute
...istant Professor - "Mechanisms of directed neural differentiation in hESC." "These funds will allow us to use non-NIH-approved hESC to develop a supply of nerve cells for brain repair," said Dr. Lipton. "We will use these new human nerve cells to treat stroke and Parkinson's disease in animal models with an eye...Cells use 'noise' to make cell-fate decisions
... regulating complex biological processes, such the differentiation of multipotent stem cells. Dr. Sel, who earned his doctorate in molecular biophysics from UT Southwestern, carried out much of the work for the Science paper while a postdoctoral research fellow at the California Institute of Technology. He joine...Fruit fly gene research may shed light on human disease processes
...y in their development and which is similar to the differentiation process for different types of cells, mirroring, for example, the way a liver cell becomes different from a blood cell. Erickson cautions that there is no direct connection between sexual development in flies and that of humans, but the logic drivi...News tips from the Journal of Neuroscience
...edia from primary neuronal cultures triggered cell differentiation and PLP-EGFP redistribution. Inhibition of tyrosine kinases or Rho GTPase also triggered PLP-EGFP movement, and the addition of neuronal-conditioned medium reduced RhoA activity. In immature oligodendrocytes, Rho mediated clathrinin-independent endoc...MIT device draws cells close -- but not too close -- together
... deeply which surface molecules trigger liver cell differentiation and which soluble molecules maintain it. Such information will help the team devise different approaches to engineering liver therapeutics by helping them understand exactly which signals are needed to support specific liver cell functions. Instea...Gladstone scientists identify critical gene factor in heart development
... to understand the role it plays in cardiovascular differentiation and development. MicroRNAS, or miRNAs, seem to act as rheostats or "dimmer switches" to fine-tune levels of important proteins in cells. To learn how microRNAs do this, the team led by Dr. Srivastava, deleted the gene responsible for one microRNA in...Study shows isolation of stem cells may lead to a treatment for hearing loss
...of research will evaluate the in vivo survival and differentiation of self-renewing cochlear cell populations and potentially lead to new therapies for the numerous individuals that are going to suffer from noise-induced hearing loss in the near future....The sturdier sex? -- Study by Pittsburgh scientists finds female stem cells work better
...on," she said. "The male cells exhibited increased differentiation after exposure to oxidative stress, which may lead to cell depletion and a proliferative advantage for female cells after cell transplantation."...3 proteins may play important role in nerve-cell repair
... plays a key role in regulating nerve-cell growth, differentiation and survival, and the regeneration of long parts of the cell called axons that carry the nerve impulses. Levels of cAMP drop in mammalian nerve cells as they mature, and this is thought to explain, in part, why mature nerve cells cannot regenerate...JCI table of contents: April 12, 2007
...oic acid receptor transcriptional activity and the differentiation of myeloid leukemia cells AUTHOR CONTACT: Steven J. Collins Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. Phone: (206) 667-4389; Fax: (206) 667-6523; E-mail: scollins@fhcrc.org . View the PDF of this article at: https://www.t...Progress toward a targeted therapy for a specific form of leukemia
...r is important for the proliferation, survival and differentiation of the precursor cells that precede the formation of blood cells. Scientists also know that MYB is involved in several other forms of cancer. On the way to a new therapy The researchers are convinced that MYB can be an important target for the de...How genetic malfunction causes a form of retardation
...ally, SHP-2 plays a role in the pathways governing differentiation of immature precursor cells into neurons and glial cells. Unlike neurons, which conduct nerve impulses, glial cells are supporting cells that surround neurons and insulate them from one another. In experiments with cultured precursor cells, the res...Stem cell identity in culture may strongly depend on the cellular microenvironment
... are in line with the currently emerging view that differentiation is context dependent rather than a pre-programmed attribute of the cells. In practice, this work provide a rationale to research strategies that aim to increase the efficiency of stem cell-related culture methods and, perhaps, even to develop stem ce...