Interaction between stem cells and their niches key to differentiation
...n important role in determining germline stem cell differentiation in Drosophila, its equivalent in mice, miwi, has been shown to be the key gene involved in development of sperm cells. In humans, Lin's team discovered in 2002 that overexpression of the hiwi gene, a piwi-like gene in human, has been implicated in th...New insight into regulation of blood stem cells
...ul for future studies aimed at directing stem cell differentiation in a variety of potential therapeutic contexts. Bl...latelets. The genes that control proliferation and differentiation have been difficult to study using traditional gene disruption methods because loss of genes thought...Experimental radar provides 3-D forest view
...rs can vary considerably, for example enabling the differentiation of separate crop species in the same field, or telling sea ice from open water. The new generation of airborne radar sensors go one better than ASAR because they include full quad-polarisation capability: this means their signal can be retrieved sim...UCSD team discovers specialized, rare heart stem cells in newborns
...CSD) School of Medicine. The cells are capable of differentiation into fully mature heart tissue. Called isl1+ cells, these cardiac progenitor cells are stem cells that have been programmed to form heart muscle during fetal growth. Until this new discovery, the cells were thought to be absent after birth. However...Scientists rid stem cell culture of key animal cells
...onic stem cells to differentiate appear to inhibit differentiation in mouse embryonic stem cells. Aside from feeder cells, two other sources of animal material remain in stem cell culture materials. One, Matrigel, is a product that is essentially a plate-coating matrix of cells extracted from mouse tumors. Serum rep...Tips from the Journals of the American Society for Microbiology
...dy response to the NS1 virus protein may allow for differentiation between poultry vaccinated or infected with avian influenza say researchers from Georgia. Their findings appear in the February 2005 issue of the Journal of Clinical Microbiology. Avian influenza (AI), a viral disease of poultry, causes a wide range...Newly-discovered class of genes determines and restricts stem cell fate
...govern a stem cell's fate and put a hold on future differentiation until the time is right. Understanding the molecul... of the molecular programs that regulate stem-cell differentiation is necessary for harnessing this potential....New way to make human embryonic stem cell therapy safer
...ure. And before clinical treatment, the controlled differentiation of the cells still requires research."...New tumor-suppressor gene discovered
...revealed that the mats gene is required for normal differentiation of eye cells during the development of the fly's eye. Lai's team also tackled the tough challenge of discovering how the mats gene is able to suppress the growth of tumors. "We did not find many clues when we compared the sequence of the mats gene w...Nobel laureates to open ASBMB annual meeting in San Diego
...P regulates processes from spore formation to cell differentiation to lipid biosynthesis. Pathologically, it creates the amyloid peptides of Alzheimer's disease. The Goldstein and Brown laboratory uncovered RIP through study of SREBPs, transcription factors that regulate the synthesis and uptake of cholesterol and ...Highlights of chemical society national meeting in San Diego, March 13-17
...s that regulate neural stem cell proliferation and differentiation also will be explored. ( BIOT 113 , Tuesday, March 15, 8:10 a.m., Convention Center, Room 30A-B, during the symposium, Purification Processes.) Something to sing about: Vocal cord regeneration moves a step closer to reality In a development that c...Cancerous or harmless? Three genes might tell the tale
...CSK2 (for protein convertase 2) and PLAB (prostate differentiation factor) -- might distinguish the noncancerous condition known as follicular adenoma (FA) from follicular thyroid cancer (FTC). The findings, published online by the Journal of Clinical Endocrinology and Metabolism, also provide insight into the gene...UCSD researchers maintain stem cells without contaminated animal feeder layers
...viously been shown to modulate cellular growth and differentiation in human pancreatic cells. Human embryonic stem cells cultured for several weeks under these conditions showed no change in cell form and structure. The team then eliminated each factor and pluripotency was assessed. At first, the results were narrow...Protein protects kidneys from damage caused by chronic renal disease and injury
...oal is to understand the pathways that control the differentiation of cells during development, and apply that knowledge to the disease process, so we can ultimately develop new therapies for kidney disease," he adds. Dressler's research was supported by the National Institute of Diabetes and Digestive and Kidney Di...Scientists find molecular pathway suspected in precancerous stomach lesions
...g sets it in motion again. In the mouse fetus, the differentiation of intestinal lining into stomach lining happens r...tists demonstrated that the signals that drive the differentiation of stomach lining are sent by a layer of cells, known as mesenchyme, that lie directly beneath the i...Scientists use transcription factors to increase insulin production in diabetic mice
...crucial role in pancreas development and beta-cell differentiation and also maintain normal beta-cell function by regulating several beta-cell-related genes including insulin. While these two transcription factors contributed to the increase in insulin gene expression, MafA was the most important molecule in this st...Georgia Tech research reveals how biomaterial properties control cellular responses
... direct responses in stem cells, controlling their differentiation into mature, functional cell types. The research was lead by Andrs Garca, an associate professor in the Woodruff School of Mechanical Engineering and the Petit Institute for Bioengineering and Bioscience at Georgia Tech. Benjamin Keselowsky, a post ...Royal Society study on adaptability of fish to warming oceans
...e landscape scale. Analyses indicated that genetic differentiation was high between populations on uncultivated hosts and on crops, indicating relatively limited gene flow between these two habitat types. Nevertheless certain uncultivated hosts showed greater exchange of aphid populations with the crops. These could......logy has been that default neuralization (ie., the differentiation of dissociated ectodermal cells to neural cells in culture) is caused by the dilution and thereby suppression of BMP growth factor signaling. Dr. Edward De Robertis and colleagues now show that, contrary to this traditional belief, BMP signaling is, ......r study because it is known to be important in the differentiation of cardiomyocytes. Once cells differentiate into their mature form, they usually lose their ability to proliferate. This study shows that ability can be revived....