Fundamental genes regulate human blood stem cells
... clear that the capacity for HSC proliferation and differentiation declines with age, not much is known about exactly how HSC physiology is regulated. Dr. Mickie Bhatia and colleagues from the Robarts Research Institute in Ontario used genome-wide gene-expression profiling (microarray analysis) to examine purified s...Genome of social amoeba shows its importance as research model
...or studying cell polarity, how amoeba move and the differentiation of tissues. It usually exists as a single cell organism that inhabits forest soil, consuming bacteria and yeast. When starved, however, the single cells come together, differentiate into tissues and become a true multicellular organism with a fruitin...Biologists determine genetic blueprint of social amoeba
...for studying cell polarity, how cells move and the differentiation of tissues. It also exhibits many of the properties of white blood cells. Three years ago, another team of UCSD biologists discovered that two genes that are used by Dictyostelium to guide the organism to food sources are also used to guide human whi...Eye candy: Transcriptional control of vertebrate eye development
...at "in many respects, the eyes represent a default differentiation pathway for the front end of the developing brain. To make an optic nerve and connect the eyes to the rest of the brain, this default pathway must be blocked and re-directed, and that's what the Vax genes do."...Scientists generate patient-specific stem cells, Science study says
...ers must develop methods to efficiently direct the differentiation of embryonic stem cells to specific stable cell types. Scientists must also find a way to remove the remaining animal components from the laboratory procedures. Currently, the procedure for isolating non-reproductive cells for the nuclear transfer me...Study in Royal Society journal on heritability of female orgasm
...egies restricts gene flow and leads to the genetic differentiation of populations in local habitat patches. Contacts: Dr AR Hoelzel, Biological Sciences, Durham University, South Road, DURHAM, DH1 3LE Epibiotic microbes as food and defense for marine isopods: unique symbioses in a hostile environment by Dr N Lindqu...JCI table of contents July 1, 2005
... Hospital examine the control of early chondrocyte differentiation by Ihh and the physiological role of this differentiation step in regulating chondrocyte mass and new bone composition. The researchers analyze mice carryin...Scientists streamline method for making key virus
...sal cells, the virus just sits there quietly. Once differentiation occurs, a whole new program kicks in." The virus's use of the skin cell differentiation process to jump start infection was an obstacle in the lab, says Pyeon, and prevented scientists fro...Regenerative ocular biology the focus of ARVO Conference
...less wound healing; and control of cell growth and differentiation by gene transfer. The Plenary Speaker will be Fred H. Gage, PhD, of The Salk Institute. Keynote Speakers will be Jean Bennett, MD, PhD, Mark W. J. Ferguson, BSc, DDS, PhD, FDS, FFD, FMedSci, CBE, Mark Humayun, MD, PhD, Mark Keating, MD, Robert Lavk...JCI table of contents, July 1, 2005
...served altered expression of genes involved in the differentiation of CD4 T cells, and of genes involved in the structure, intracellular movement of molecules, and toxicity of CD8 T cells. They also showed that these changes were induced only upon direct contact of B-CLL cells and healthy T cells. Identification of ...Eggs from embryonic stem cells could benefit sterile women
... an environment with growth factors sufficient for differentiation and they were not exposed to the factors responsible for the differentiation into male reproductive cells, they spontaneously differentiated into female reproductive cells even ...Researchers discover mechanism that may enable stem cell-based treatment for eye disorders
...lled GDF11 controls a keycomponent of retinal-cell differentiation during development, whichmakes GDDF11 an attractiv...wer of these endogenous stem cells by directingthe differentiation of these cells into specific retinal cell types. "The ultimate goal is to control how GDF11 and rela...$7.3 million NIH grant establishes Wellstone Muscular Dystrophy Research Center at the UI
...tem cells to discover the principles governing the differentiation of these cells into muscle-forming precursor cells that can be used for cell transplantation therapies in mouse models of muscular dystrophies. Core facility A, directed by Campbell, is an administrative core, which will coordinate and oversee the ce...JCI table of contents July 1, 2005
... the stem cell controversy: protection rather than differentiation in the kidney tubule? AUTHOR CONTACT: Lloyd G. Cantley Yale University School of Medicine, New Haven, CT USA Phone: 203-785-7110; Fax: 203-785-4904; E-mail: lloyd.cantley@yale.edu View the PDF of this article at: https://www.the-jci.org/article.ph...U of MN researchers identify genes involved with blood stem cell development
...rstood is which genes control the self-renewal and differentiation processes, and how these genes could be used to influence, or regulate, these processes. The research will be published in the July issue of the journal of Public Library of Science Biology . "If we can find a way to coax blood stem cells to self-re...JCI table of contents August 1, 2005
...mal stroke models. Moreover, G-CSF drives neuronal differentiation of adult neural stem cells in the brain, and has profound impact on long-term functional outcome after cerebral ischemia. The authors show that G-CSF itself is a neuronally expressed protein in the brain, and that systemic G-CSF can penetrate the int...Stepping up therapy for stroke and other CNS disorders
...mal stroke models. Moreover, G-CSF drives neuronal differentiation of adult neural stem cells in the brain, and has profound impact on long-term functional outcome after cerebral ischemia. The authors show that G-CSF itself is a neuronally expressed protein in the brain, and that systemic G-CSF can penetrate the int......will elucidate critical aspects of cell growth and differentiation that are altered during the formation and growth of tumors. Research on tissue-specific stem cells from adults may reveal the body's innate maintenance and repair mechanisms. Embryonic stem cells have the ability to transform into the cells of ever...Brain size may depend upon how neural cells are cleaved
...peutic use, the role of G protein signaling in the differentiation of such progenitor cells is going to be a very exciting area to explore," she said.......velopment depends on appropriate specification and differentiation of the unique organ identities (e.g. petals, stamens, ovules). An interesting aspect of this research is the finding that the expression of many trapped genes is restricted to particular subdomains of the proximodistal axis of petals and stamens, imp...