Tag: "differentiation" at biology news
Master regulatory gene found that guides fate of blood-producing stem cells
...y gene to shift the balance of self-renewal versus differentiation
so that all the immature, leukemic cells differentiate and die. Over the past 10 years, several gene families have been suggested to be important in regulating HSC fate-for example homebox, wnt, notch 1, and telomerase genes. Emerson and colleagues...
NIGMS funds new stem cell centers
...for the first year of funding to study the growth, differentiation
and genetic alteration of human embryonic stem cel...study how specific proteins control the growth and differentiation
of human embryonic stem cells. The team will also analyze genetic networks and study DNA replication...
Mount Sinai receives NIH funding for stem cell research
...nt Sinai School of Medicine will study the growth, differentiation
and genetic alteration of human embryonic stemcells. The group will focus on developing methods to genetically modify stemcells and will study the molecular signals that cause them to differentiateinto red blood cells. "We expect the center to play a...
A novel method to propagate stem cells
...s. Their novel method creates an on/off switch for differentiation
of tissue-specific stem cells: they can multiply without differentiation, and they can also become normal brain cells. The authors also managed to cultivate the brain stem cells without re-creating the rarefied neurosphere. To grow their stem cells...
Stem cells bring fast direct improvement, without differentiation, in acute renal failure
...ntial late phase contributions to organ repair via differentiation
of stem cells into cells that have been destroyed in ARF," the study noted....
Other highlights in the September 7 JNCI
...n signaling pathway plays an important role in the differentiation
and migration of melanocytes, the cells from which melanomas arise, Nadem Soufir, M.D., Ph.D., of the Hopital Bichat-Claude Bernard in Paris, and colleagues investigated whether mutations in the gene endothelin receptor B (EDNRB), which is involved i...
Formula against infertility
...ures on the factors influencing the origin and the differentiation
of stem cells. Philippe Collas of the University o...re searching for substances that contribute to the differentiation
of stem cells. Thus Tomohiro Kono of the Tokyo Agricultural University, Japan, presented the creatio...
The making of a fat cell
...oliferation of mesenchymal stem cells, followed by differentiation
into fat cell precursors called preadipocytes. Mesenchymal stem cells can differentiate into various cell types, including bone, cartilage, muscle, nerve, and fat. Fat precursor cells then migrate and proliferate at the site of fat production, where ...
What causes psoriasis?
...ctors and is known to regulate cell proliferation, differentiation
and stress responses. However, mice lacking JunB do not show any signs of psoriasis. It is the combined deletion of JunB and c-Jun, a closely related gene, that brings forth the typical symptoms of the disease in mice. The disease-prone animals which...
Tissue rigidity promotes tumor progression
...ve for understanding the molecular basis of tissue differentiation
and tumor formation. According to Dr. Weaver, "ERK and Rho appear to be part of an integrated mechanoregulatory circuit that functions to link physical cues through integrins to molecular pathways that control cell growth. A chronic increase in cytos...
JCI table of contents October 1, 2005
...a physiological regulator of stimulated osteoclast differentiation
and skeletal mass. TITLE: FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner AUTHOR CONTACT: Steven L. Teitelbaum Washington University School of Medicine, St. Louis, MO USA Phone: 314-454-8463; Fax: 314-454-5505; E-mail: teitel...
Study in Royal Society journal on first observation of giant squid in the wild
... with fossils, we have determined that much of the differentiation
among present-day Nothofagus lineages took place after Gondwana broke up. Rather than being "ancient relicts", current species of Nothofagus appear to be the descendants of a single species that survived a major extinction. Contact: Dr LG Cook, Scho...
UW-Madison small-scale research receives big boost
...of atomic-scale materials to direct the growth and differentiation
of embryonic stem cells. Initially established in ...could be used to influence or guide the growth and differentiation
of cells, including human embryonic cells." Under a secondary aspect of that work, researchers in th...
Researchers show key protein necessary for normal development of red blood cells
..., the production of blood cells involves a complex differentiation
pathway that involves the interaction of many molecular players and proteins. In humans, there are four globin genes clustered on chromosome 11 in the order in which they are "turned on" or expressed. These genes include the epsilon-globin gene, two...
Nanoparticle created as diagnostic, therapeutic agent; brain tumors targeted
...s. The fMF material provides improved brain tissue differentiation
and a dark outline of the tumor margin, making surgical removal more precise. These preliminary results will be published in the scientific journal, Radiology. In addition the VCU-Virginia Tech team also has demonstrated that when using the fMF as a ...
Stem cells' electric abilities might help their safe clinical use
...ause electrical activity is known to regulate cell differentiation
and proliferation," says Li. "To my knowledge, the...and observed the electric current's effect on cell differentiation
and proliferation. "In a number of different cell types, from cancer to T-lymphocytes, potassium cha...
Study sheds light on signaling mechanism in stem cells, cancer
...s efforts to use signaling molecules to direct the differentiation
of embryonic stem cells in the culture dish, with ...g signaling plays a critical role in prompting the differentiation
of neural stem cells into the various forms of neurons in the brain," he says. "The discovery of the...
Nine minority physiology grad students each get $18,000 Porter Fellowship from APS
...insight into how molecules regulate endocrine cell differentiation
in the intestine. Jeffrey Mason University of California Davis Mr. Mason's research is focused on investigating the mechanisms behind abnormal fetal and placental development. He plans to target cells within the early embryo having abnormal devel...
Forgotten by evolution?
...lls could be the mere remnants of former embryonal differentiation
processes, or, in other words, "footprints" of evo...ls. This provided evidence for the beginnings of a differentiation
process. But this process was only apparently halfway complete. So, for example, after the activatio...
Scientists crack code for motor neuron wiring
... established that certain Hox proteins control the differentiation
of motor neurons into columns in the spinal cord. ... proteins, their chromosomal organization, and the differentiation
and connectivity of motor neuron pools," he said. Jessell said this code appears to govern three lev...
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