From one cell, many possible cures
...produce mesenchymal stem cells and to direct their differentiation into bone, cartilage, muscle, heart muscle, fat or nerve tissue," Ma said. "The tissues grown then will be suitable for clinical transplantation." He added that stem cells can live for up to 40 days within the bioreactor. Ma's research has attracted ...Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method
...o an earlier developmental stage. Shortening the differentiation process is important, she notes. The longer cells are grown and allowed to mature in culture before transplant, the less able they are to survive harvest for transplant. "We transplant cells at two weeks in stage four of development and not after thr...CO2 sensing proves critical for fungal pathogens to adapt to life in air and human hosts
... study implicates a key role for CO2 in growth and differentiation in the fungal kingdom. The identification of a link between CO2 sensing and fungal virulence may have broad implications for the study of microbial pathogens and the role of adenylyl cyclase in virulence trait regulation by CO2. Furthermore, it may ...Regenerating worms help elucidate stem cell biology
...environmental cues that influence the division and differentiation of their neoblasts, Snchez Alvarado considers planaria an excellent model to tease out the intricacies of adult stem cell biology. "I think they probably have a lot to teach us about how a population of stem cells is being regulated in vivo, rat...Silenced gene in worm shows role in regeneration
...ed a role of this protein in regulating the normal differentiation and function of daughter cells. The researchers postulated three theories why the worms could not regenerate or maintain cells after smedwi-2 was silenced: The stem cells were not responding to tissue damage or homeostasis signals. The stem cell ...Accentia Biopharmaceuticals acquires exclusive license
...irmation of the diagnosis of chronic sinusitis and differentiation of it from allergic rhinitis," said Martin Baum, President and COO of specialty pharmaceuticals at Accentia. "In early 2006, we expect to launch MDTurbo TM , a unique, patented delivery device for metered dose inhalers used to treat asthma and chron...Similar stem cells in insect and human gut
...gulation of gastric motility as well as growth and differentiation of the gut (enteroendocrine cells). In vertebrates, cells of the intestines are continually replenished by stem cells. Up to now, stem cells had not been observed in the gut of the fruitfly. To see if stem cells were at work, the researchers labele...Blazing a new path for Emery-Dreifuss Muscular Dystrophy
...s of cell life including gene expression, mitosis, differentiation and apoptosis (programmed cell death). MAP kinases have attracted basic researchers for decades, and pharmaceutical companies have begun developing MAP kinase inhibitors as potential therapeutic agents. The trail blazed here by Muchir and colleagues ...A crucial role for TGFbeta signaling in congenital eye disorders
... show that TGFbeta signaling is crucial for proper differentiation and morphogenesis of NC-derived cells in eye struc...res. Conceivably, TGFbeta might be able to support differentiation not only during eye development but also at later stages. If so, this might open up new strategies f...OHSU discovery sheds light into how stem cells become brain cells
...velopment of drugs targeted at promoting stem cell differentiation in the adult nervous system." While much more research needs to be conducted, the scientists believe these findings could play a role in the development of therapies to combat a variety of diseases and conditions. For instance, Parkinson's disease i...Researchers uncover remarkable developmental pathway
...of regulatory proteins that aids in organizing the differentiation of embryonic cells and gives an organism its overall shape. Although researchers had known that morphogenetic fields were responsible for the embryo's remarkable resiliency, very little was understood about how they function at the molecular level, s...Gladstone researchers hone in on differentiation of heart stem cells
...opment of many kinds of tissues and is involved in differentiation of cardiac stem cells into muscle cells. "Given th...understanding cardiac progenitor determination and differentiation in current cardiac regenerative medicine, our study will contribute to the understanding of how hear...JCI table of contents: January 4, 2006
...tion of SMC gene expression that can influence the differentiation of SMCs during both normal development and disease states such as vascular injury. TITLE : Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo AUTHOR CONTACT: Gary K. Owens University of Virginia Health Scie...Retinol for combating leukemia cells
...ke part in three processes: in cell death, in cell differentiation and in cell proliferation. Some ten years ago the Department of Cell Biology and Histology at the University of the Basque Country initiated research into how cell death was boosted by means of retinoids. It was thought that this potential could be ...Mouse model reveals that oncoprotein induces abnormal preleukemic blood cell progenitors
... some leukemia fusion proteins that interfere with differentiation of blood cells may maintain normal numbers of blood stem cell precursors, but that these precursors may not be able to repopulate the blood adequately. In addition, such fusion proteins may induce formation of abnormal precursor cells that are target...Vitamin A analog is a potential lung cancer preventative with few side effects
... because they help regulate cell division, growth, differentiation and proliferation. A new class of these vitamin A relatives has been created that includes bexarotene. These substances are called the rexinoids, so named because they are attracted to a molecule on cell surfaces called RXR. Rexinoids tend to be much...Discoveries may advance stem cell therapy for Parkinson's, cancer patients
... of Msx1, leading to other events important to the differentiation of these nerve cells, they show. Moreover, the researchers report that expression of Lmx1a in embryonic stem cells results in a robust generation of dopamine neurons with a correct midbrain identity. "We spent a lot of effort and are now confident th...Cancer researchers found a new mechanism potentially explaining evolution of signalling pathways
...bryonic development, cells regulate the growth and differentiation of each other by secreting extracellular signalling molecules (growth factors or morphogens), which bind to receptors present on the surface of other cells. The receptors in turn activate intracellular signalling pathway composed of proteins that rel......in myogenesis, the role of A-type lamins in muscle differentiation has remained unclear. Dr. Kennedy and colleagues u... pRB, desmin and M-cadherin), and reduces myoblast differentiation potential. Furthermore, forced expression of MyoD or desmin in Lmna-deficient myoblasts restores thi...Hermaphroditic plants have genetic advantage in areas where extinctions are frequent
... diversity within populations and increase genetic differentiation between populations," explain the authors in a for...n is frequent. As expected, diversity was low and differentiation high in hermaphrodite populations of the Mercurialis annua. In contrast, populations that contained ...