OHSU lab links gene to aged skin problems, cancer
...ad7 over-expression shifts the epidermal stem cell differentiation program from forming hair follicles to sebaceous glands, causing the mice to exhibit balding and oily skin. Surprising to the researchers was that, independent of its normal role in blocking signaling from a group of genes called Smad, Smad7 shuts d...UW-Madison work on stem cells, cardiac health to be presented at ACS
... because the size of these colonies influences the differentiation and eventual fate of the cells." Jeff Mohr will present these findings in a poster session from 5:30-7:30 p.m. on Wednesday, Sept. 13, in Hall D of the Moscone Center....National Institutes of Health to map genomic changes of lung, brain and ovarian cancers
...c alterations in genes associated with cancer; and differentiation of cancer subtypes based on genomic changes. In addition, the pilot project will establish a publicly available integrated database that scientists can use to generate new knowledge through research. TCGA data will be made available through public ...News tips from the Journal of Neuroscience
...nzyme in dopamine synthesis. Retinoic acid-induced differentiation of cells expressing the A53T synuclein mutant increased synuclein aggregates. Increasing intracellular dopamine inhibited the transformation of mutant -synuclein from soluble oligomers to Triton-insoluble aggregates....Researchers identify a key regulator for skin stem cells
...rchers analyzed how switching on Tcf3 affected the differentiation of embryonic skin stem cells. They found that activating the gene in mice blocked differentiation of all three types of mature skin cells -- epidermal, sebaceous, and hair follicle. "We've known for......that the amount of funding data and its respective differentiation provides far more information than just funding statistics. "First and foremost, the data provides information about top-level research in Germany, structural aspects of research funding, and the academic focus of individual research institutions and...A new way to treat colon cancer?
...id in the cell. Retinoic acid is essential in cell differentiation the function that determines what type of cell forms and how long it lives. This study observed that in both zebrafish and human tissues with APC mutations, there are high CTBP levels and low capability to produce retinoic acid. In APC-mutated tissu...Possible evidence of cell division, differentiation found in oldest known embryo fossils
...rom five countries has discovered evidence of cell differentiation in fossil embryos that are more than 550 million y...al cell division timing and embryonic cell lineage differentiation evolved before 551 million years ago," they write in the introduction to the Science article. "One...Gene involved in common birth defect also regulates skin biology
...revealed that IRF6 regulates the proliferation and differentiation of keratinocytes -- the main cell type in the epid...ts newly identified role in cell proliferation and differentiation may mean that IRF6 also is involved in other medically important areas of biology such as cancer and...Double trouble for RA patients: PLC-gamma-2 regulates osteoclastogenesis and B cell differentiation
...mune response also leads to the recruitment and/or differentiation of cells known as osteoclasts -- which are cells t...C-gamma-2, which was already known to regulate the differentiation of B cells (one of the immune cells crucial to the autoimmune response seen in RA), is required for ...JCI table of contents: October 19, 2006
...LC-gamma-2 regulates osteoclastogenesis and B cell differentiation Rheumatoid arthritis (RA) is best known as a ch...mune response also leads to the recruitment and/or differentiation of cells known as osteoclasts -- which are cells that degrade and resorb bone. Current treatments fo...Stretching bone marrow stem cells pushes them towards becoming blood vessel
... completely achieve the efficient guidance of cell differentiation in a lab, we will likely need a combination of chemical and mechanical factors." "We're definitely a major step closer to developing a process of tissue engineering that could one day have clinical applications," added Kurpinski....Scientists identify synthetic compound that keeps stem cells young
... proteins RasGAP and ERK1, both of which have cell differentiation inducing activity. "The mechanism of pluripotin suggests new strategies for maintaining and propagating stem cells," says Ding. "Such a discovery of a single small molecule that operates through two different classes of targets to achieve a desired...JCI table of contents: November 9, 2006
...for engineering tissues. TITLE: Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells AUTHOR CONTACT: Catherine M. Verfaillie Katholieke Universiteit Leuven, Leuven, Belgium. Phone: +32-16-33-02-95; Fax: +32-16-33-02-94; E-mail: catherine.verfaillie@med.kuleu...How to grow muscle cells in a dish
...for engineering tissues. TITLE: Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells AUTHOR CONTACT: Catherine M. Verfaillie Katholieke Universiteit Leuven, Leuven, Belgium. Phone: +32-16-33-02-95; Fax: +32-16-33-02-94; E-mail: catherine.verfaillie@med.kuleu...One signal elicits thousands of answers
...rs, for example, can lead to growth of a cell, its differentiation or proliferation. Defects in these tightly regulated and controlled processes can cause cancer and other human diseases. In recent decades, knowledge of the important players in signal transduction has been painstakingly accumulated, mainly through t...News tips from the Journal of Neuroscience
...other factors to this pool might then kick-art the differentiation needed to promote regeneration. 3. CCK and the Nocebo Effect Fabrizio Benedetti, Martina Amanzio, Sergio Vighetti, and Giovanni Asteggiano The placebo effect needs no introduction: give patients a "sugar pill" along with a suggestion that it ...Prenatal alcohol exposure appears to increase an infant's stress response
...posure is occurring before there is any structural differentiation in the cells that will eventually show these aberrations. 'What could alcohol be doing selectively to some germinal cells that presumably does not kill them, but alters their performance after they have multiplied, migrated and matured?' This is a ...Glucocorticoid plays key role in skin abnormalities induced by psychological stress
...e showed significantly better: proliferation differentiation permeability barrier function stratum corneum integrity The experiment demonstrated the important role that glucocorticoids play in inducing the skin abnormalities brought on by psychological stress. While the researchers hope the study will ......he proliferation of beta cells after birth and the differentiation of those cells into fully functioning units. They found that thirty to forty percent of the beta cells of PERK-deficient mice are physically unusual. The most obvious abnormality is that proinsulin is found the endoplasmic reticulum, instead of bei...