First molecular simulation of a long DNA strand shows unexpected flexibility
...ritical for many cellular processes including cell differentiation and DNA replication. Although also observed in recent experiments, this unusual DNA flexibility is still unexplained. "Now seeing that DNA is not as hard to bend may lead to radical changes in our perspective," said Onufriev. "We are using these deta...Detailed 3-D image catches a key regulator of neural stem cell differentiation in action
...molecular "on" and "off" switches orchestrates the differentiation of embryonic stem cells into different tissue type...rch and potential therapies. "At the moment, the differentiation of stem cells into neurons in a Petri dish is a little bit like a black box and not very efficient,"...Muscle and bone from an ink-jet printer
... using growth factors to control proliferation and differentiation in populations of muscle-derived stem cells, or MD...tic abnormalities. Spatial patterning of stem cell differentiation through delivery of bio-inks with an ink-jet printer will offer the Pittsburgh researchers a whole n...Pittsburgh-based team engineers muscle, bone cell differentiation with aid of ink-jet printer
...e directed to differentiate down various cell-fate differentiation pathways (e.g. bone- or muscle-like). "Previousl...ronments by patterning bio-inks that could promote differentiation towards multiple lineages simultaneously," explained Phil Campbell, research professor at Carnegie M...Embryonic stem cells do better on bumpy nanoscale mattress
...ions, of cell culture surfaces influences HES cell differentiation and self-renewal, according to the researchers. For HES cells to realize their potential in clinical medicine, they would have to be cultured in great quantities and with great fidelity to their pluripotent phenotype. Fine-tuning their nano-micro top...Leibniz Prize winners 2007 announced
...ses that underlie the formation of neurons and the differentiation of the cerebral cortex. Her discovery, that the br...ibution to the endeavour of directing the targeted differentiation of stem cells and thus solving one of the key problems of applied stem cell research. Magdalena Gt...UCSF stem cell study reveals cells' capability in mouse brain tissue repair
...ding of the full pathway of genes needed to prompt differentiation of neural stem cells both in the brain and in the culture dish. In this sense, he says, "the deletion of Numb and Numblike was a test case." In collaboration with other UCSF neuroscientists, as well as neurosurgeons, Kuo is currently exploring whet...JCI table of contents: December 14, 2006
...own that in vitro, IFN-gamma directly inhibits the differentiation of cells that destroy bone (osteoclasts) and indirectly promotes their differentiation. In this study, which appears online on December 14 in advance of publication in the January print issue of the Journal of Clinical Investigation, Roberto Pacifici...Run amok enzyme causes same problems in both humans and fruit flies
...guishing problems: Proteins (Numb) involved in the differentiation into neurons and neuroblast self-renewal (aPKC) are not sorted to their proper sides of the cell, and the mitotic spindle that provides cortical polarity becomes misaligned. The subsequent splitting leads to new cells with improper proteins mixes, in...Researchers make progress in studying genetic traits of India-born populations
...an ancestry groups, with relatively little genetic differentiation among the Indian populations. Although the study used participants that may not reflect a random sample from India, these results still suggest that the frequencies of many genetic variants are distinctive in India compared to other parts of the worl...'Speechless' and 'Mute' help break the silence of the leaves
...nd animals genes that switch on and off cell-type differentiation programs from precursor stem cells is intriguing and exciting, Torii says.......controls both testosterone synthesis and germ cell differentiation in male mouse testis. The researchers found that mice deficient for SHP displayed an earlier onset of fertility, due to an absence of the normally repressive effects of SHP on testosterone production and germ cell differentiation. Dr. Auwerx is hopef...JCI table of contents: Feb. 1, 2007
...uring cardiovascular development and smooth muscle differentiation AUTHOR CONTACT: Jonathan A. Epstein University of... expenditure, decreased fat degradation, increased differentiation of fat cells, and increased insulin resistance (one of the main triggers of type 2 diabetes and a co...New player in commitment to life as a fat cell
...ce it is both necessary and sufficient for adipose differentiation both in vitro and in vivo, the researchers said. Treatments that inhibited XOR activity in cells blocked fat formation and PPAR-gamma activity, the researchers reported. Likewise, increased XOR levels hiked activity of the PPAR-gamma receptor in bo...Good for the goose, not so great for the gander
...o a male or female. The model suggests that sexual differentiation may exact a high biological cost reduced function... model have been intrigued by the idea that sexual differentiation might limit life span. And, so far, no one has challenged his fundamental proposal describing how th...Neuronal differentiation of human neural stem cell grafts in adult rat spinal cord
Neuronal differentiation of human neural stem cell grafts in adult rat spin... Human neural stem cell grafts can show neuronal differentiation in the normal and injured spinal cord of adult rats. Researchers from Johns Hopkins University and N...New protein super-family discovered with critical functions for animal life
...tal proteins that are critical for cell growth and differentiation and whose further study is expected to benefit res...ected previously and had been shown to control the differentiation of cells into organs in worms, fish, and mice. Deletion of these their DANGER genes led to gross st...CIRM awards $5.9 million to Burnham Institute
...hima, Professor and Program Director - Trophoblast differentiation of human ES cells Hudson Freeze, Professor and Program Director - Role of Glycans in Human Embryonic Stem Cell Conversion to Neural Precursor Cells Zhuohua Zhang, Assistant Professor - Modeling Parkinsons Disease using Human Embryonic Stem Cells Ziwe...UCLA scientists garner 7 grants to fund leading-edge embryonic stem cell research
...5,024 Role of mitochondria in self-renewal versus differentiation of human embryonic stem cells. Principal Investigator Hanna Mikkola, Co-Investigators Owen Witte and Ken Dorshkind: $577,037- Improving microenvironments to promote hematopoietic stem cell development from human embryonic stem cells. Princip......he first time such an advanced state of nerve cell differentiation has been achieved from human skin, according to le...doing such things, well have to improve nerve cell differentiation and prove that they can transmit nerve impulses," concludes the researcher....