Study of genomic DNA leads to new advances in cancer diagnostics
...cell interacts with its microenvironment (ECM) and direct changes to the cytoskeleton and finally to the chromatin. Such changes can now be measured directly at the chromatin level. These findings may provide the basis for the design of a new generation of cancer therapeutic agents....Beyond lithium for bipolar disorder
...ears to be switched on by lithium, suggesting more direct targets for drugs to treat the disorder. Lithium is known to inhibit the production of an important cellular switch, called inositol monophosphate, so the researchers set out to find genes that were activated by this inhibition. They treated slices o...Salk polio vaccine celebrates 50th anniversary
...ilkins). Max Delbrck, Ph.D., for showing how genes direct normal development and mutations cause abnormal development (with Alfred Hershey and Salvador Luria). Development of vaccines came to be seen by the public as a priority, and great strides were made in protecting unborn babies, children, and adults f...Introduced foxes transformed vegetation on Aleutian Islands from lush grasslands to tundra
...ects on the whole ecosystem are as dramatic as the direct effects on the seabirds. "Introduced species are a global phenomenon, and we tend to focus on the direct effects, such as the reduction or extinction of species that are consumed by an introduced predator....Babies born preterm cost businesses big money: Hospital charges estimated at $7.4 billion annually
...ng disease, vision and hearing loss. Besides the direct cost to businesses, premature birth also causes lost productivity. The Thomson Medstat analysis found that premature babies spend nearly 17 days in the hospital over the 12 months following birth, compared to 2 to 3 days for healthy, full term babie...Researchers reveal the infectious impact of salmon farms on wild salmon
...s although European studies have not measured the direct transfer of sea lice from farms to wild salmon. Ho...previous studies have not shown nor quantified the direct transmission. This study captures the chain of events." "Part of the contentious debate about sea li...Components in grapes inhibit enzyme key to proliferation of cancer cells
...ies now under way in animal models, we are getting direct evidence that these components in grapes work synergistically in fighting cancer. They have to work together to obtain the potency that works." The researchers are tracking where specially radiolabeled flavonoids congregate in rats, in a project fund...DFG awards 2005 Heinz Maier-Leibnitz Prize
...oral degrees, has discovered that certain proteins direct the growth hormone to where it is required. The identification of these PIN proteins is a groundbreaking discovery in molecular biology and biochemistry and opens up new perspectives for plant growers and space biologists. Moreover, the Czech-born sc...'Color-blind' method opens new doors in DNA sequencing
...a crime or a battlefield. "We could eventually do direct detection of a DNA sequence from native DNA" without manipulation now performed in the laboratory, said Dr. Michael L. Metzker, assistant professor in the BCM Human Genome Sequencing Center and adjunct assistant professor of chemistry at Rice. "We co...'Free-for-all' illegal logging of mahogany in Peruvian parks, says Duke-based monitoring group
...olved many different organizations, so it wasn't a direct result of our investigation," said Fagan, a Nicholas School graduate. "But I think we provided a really strong case for making the area a national park." While applauding the Peruvian government's action as a welcome step towards additional protectio......d that MT1-MMP helps propagate the PDGF- signal to direct mural cell investment in the microvasculature. MT1-MMP-null mice have severely compromised vascular architecture, with irregularly sized vessels and weakened vessel walls. Dr. Weiss explains that "These findings, coupled with complementary reports fr...Balancing act at chromosome ends
... negative), is an actively investigated area, with direct implications for understanding aging and cancer. Telomeres are elongated by an enzyme called Telomerase (hTERT). Telomerase is generally only active in fetal, germ, and cancer cells; it is normally repressed in most somatic (body) cells. This new wo......ed 2-D electronic spectroscopy to record the first direct measurement of electronic couplings in the Fenna-Matthews-Olson (FMO) photosynthetic light-harvesting protein, a molecular complex in green sulphur bacteria that absorbs photons and directs the excitation energy to a reaction center where it can be c...Two-part blood pressure control suggests new approach to hypertension therapy
...failure, they added. "Our study provides the first direct evidence that the job of blood pressure regulation is split into two parts that controlled by the kidneys and that controlled by other systems throughout the body," said Thomas Coffman, M.D., chief of nephrology at Duke University Medical Center and...JCI table of contents April 1, 2005
...ich regulates blood pressure. The authors provide direct evidence that actions of AT1 receptors both inside and outside the kidney each contribute to determining the level of blood pressure. In an accompanying commentary, Michael Mendelsohn states that the findings have "important implications for the way...Growth factor in baby formula could reduce NEC, most devastating GI disease in preemies
...igher than breast-fed babies, indicating important direct benefits of mother's milk. "Using a neonatal animal model of NEC, we have shown that when one protein found in breast milk epidermal growth factor (EGF) is added to formula, the incidence of NEC decreases by 50% compared to animals fed formula a...In asthma, it's not the drugs but the inflammation that increases cardiovascular risk, damage
...rtant because they provide the first evidence of a direct contribution of asthmatic conditions to cardiovascular complications, independent of any asthma drug therapy," according to Surovi Hazarika, the lead author. "If the findings are confirmed in human trials, asthma could be identified as a potential ri...'Second messenger' NAADP shows fast, dose-related impact on satiety cycle
...AADP in Ca2+ signaling in pancreatic anicar cells, direct demonstration of changes in NAADP levels in respon...d, "Our data in this experiment provides the first direct evidence that cholecystokinin elicits a rapid, dose-dependent and selective increase in NAADP, and t...14 highlighted physiology papers from IUPS 2005: From 'genomics to functions'
...n cholecystokinin-induced satiety." It's the first direct evidence that cholecystokinin elicits a rapid selective increase in NAADP, and unequivocal evidence NAADP is a crucial messenger employed by cholecystokinin. "Rapid, selective and dose-dependent elevation of the second messenger NAADP." Physiology 93...For sardine and anchovy, El Nio events do not always have the same effects
...ate. Its geographical location brings it under the direct influence of disturbances generated by the El Nio-La Nia events which arise every 3 to 7 years. Other climatic cycles, called El Viejo-La Vieja by reference to the first two, also bear influence, but on a longer time-scale with a period of about 50 y...