Molecular pathway linked to breast cancer recurrence
...target for a new generation of cancer therapeutics directed against specific molecules involved in breast cancer recurrence," explains Dr. Chodosh....Cytokinetics presents data on CK-1827452
..., Cytokinetics. The presentation details research directed to the discovery and optimization of small molecules that improve cardiac function in a manner consistent with the therapeutic hypothesis, specifically that improving cardiac contractility by directly activating cardiac myosin can potentially address...Gaining ground in the race against antibiotic resistance
...re no known inhibitors of metallo--lactamases, but directed evolution could help in their design, Vila said, by giving drug makers a reliable prediction of what the next generation of enzymes will look like. "Since we were able to reproduce the natural evolution in the test tube, you could generate a more eff...'Underground' tunnels discovered as means for communication between immune system cells
... solve some of the mystery of how a local stimulus directed at a very small number of cells can be amplified and result in a successful immune response," explained Dr. Watkins. "Quite possibly, the tunneling nanotubules enable a small number of dendritic cells with captured antigens to reach other dendritic c...Tissue stiffness drives tumor formation
...within a cell that give shape and the capacity for directed movement. When the researchers increased the stiffness of the gel in which experimental cells were grown, Rho activity increased, as well as the number and size of focal adhesions, clusters of integrins that create a connection between integrins and ...Study in Royal Society journal on first observation of giant squid in the wild
... risk (increased approach speed, larger size, more directed approach), increased distance to safety, and experience with predators amplified the perception of risk in prey. While fish tolerated closer approach when in larger schools, other types of animals fled at greater distances when in larger groups. An...Children's Hospital of Pittsburgh to lead international study of acute liver failure in children
...tive treatments." The pediatric acute liver study, directed from Children's, will be divided into three aspects: Developing a registry of patients admitted to hospitals for acute liver failure. This registry will provide important epidemiological data vital to understanding the causes of acute liver failu...Image of myosin-actin interaction revealed in cover story of Molecular Cell
...d by collaborators from the University of Vermont, directed by Kathleen Trybus, Ph.D....Researchers: Deep sleep short-circuits brain's grid of connectivity
... magnetically generated pulses of electricity were directed to specific regions of the brain. The pulses stimu...secrets of consciousness, the new study, which was directed in part by Marcello Massimini, a research associate in the UW Psychiatric Institute and Clinics, may...Molecular research suggests shift needed in how some drugs are created
... crystallography. Using this technique, X-rays are directed into molecules of IRAK-4 that have been coaxed to form crystals. The diffraction data from the experiments allow the structure to be visualized down to angstrom-level resolution (one hundred-millionth of a centimeter). The structure of IRAK-4 was det...Phytochemicals may protect cartilage, prevent pain in joints
...ore research is needed," said Konstantopoulos, who directed and supervised the experiments. "But these discoveries could provide guidelines for designing an ideal hydrodynamic environment in bioreactors for generating functional cartilage as well as for the treatment of osteoarthritis."...Burnham Institute to collaborate in NCI funded Center of Cancer Nanotechnology Excellence
...maging agents and cancer therapeutics. The project directed by Dr. Ruoslahti aims to develop nanodevices that ...ribute as co-principal investigator on a component directed by Dr. Michael Sailor. Dr. Mustelin will study the interaction of nanomachines with cells, looking ...Defense center at NJIT draws satisfied customers at annual signing
...haplin, an attorney and Ridgewood resident who has directed DPTAC since 1997. At the event, Altenkirch will sign an annual contract with the Department of Defense. To date, DPTAC's influence has resulted in awards of more than $966 million in contracts in New Jersey. Chaplin will receive an award of exc...Why a whale shark's spots could help save its skin
...ble to know whether conservation efforts should be directed locally or internationally, or whether marine reserves are effectively protecting them. Whale sharks are listed as "vulnerable to extinction" by the World Conservation Union (IUCN). Up to 20 metres long, the whale shark is the world's largest fish an...'An Eye on Katrina: Geoscience Perspectives on a Catastrophic Hurricane' at GSA Next Week
...s. Requests for interviews after Tuesday should be directed to Heidi Koontz, USGS Public Affairs Specialist, at 303-202-4763 (office) or 720-320-1246 (cell). * Other Post-Meeting Contact Information Mark A. KulpUniversity of New Orleans mkulp@uno.edu Frank T. ManheimGeorge Mason University fmanhei1@gmu.edu...W.M. Keck Foundation grant advances study of biocompatible liquid crystals
...Keck Foundation received by Kent State and will be directed to the study of a new class of matter that bridges biological and liquid crystal research--biocompatible liquid crystals. The multi-disciplinary study, conducted by the Department of Biological Sciences in collaboration with the Glenn H. Brown Liqu...JCI table of contents November, 2005
...ed may be a potential target for pharmacotherapies directed at preventing atherosclerosis and other cardiac occlusive diseases. TITLE: PARa inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a AUTHOR CONTACT: Florence Gizard Pasteur I......ushing forces. These pushing forces arise from the directed growth of the filaments by the addition of molecular building blocks. One important problem is to understand the dependence of these pushing forces on the number of filaments within the bundle. This research topic is currently being pursued within th...Other highlights in the October 19 JNCI
...tment strategies are needed. Combination therapies directed against nonoverlapping molecular targets may be the most likely to succeed. Tayyaba Hasan, Ph.D., of Massachusetts General Hospital in Boston, and colleagues tested C225--which inhibits the epidermal growth factor receptor--and PDT--which involves la...NIH joined by advocacy groups to fund research on autism susceptibility genes
...ility Genes by High-Throughput Chip Resequencing," directed byMichael Zwick, Ph.D. The three-site collaborative project uses novel statistical methods, finemapping of candidate regions across the genome, and animal models in thesearch for autism susceptibility genes. Cold Spring Harbor Laboratory's proposa...