A new focus for the mechanism of nerve growth
...Myosin II motors are involved in functions such as directed cell movement, cell division and wound closure. While skeletal myosins have been studied in detail, non-muscle myosins are just beginning to be understood and this work identifies a new role for them. The researchers, led by Paul Forscher , profess...Chemist wins national award for contributions in medicinal chemistry
...sed to treat glaucoma. More recently, Anderson has directed research efforts at Merck and DuPont Pharmaceuticals on chemotherapeutic agents for the treatment of AIDS. This research resulted in the development of the HIV protease inhibitor Crixivan and the HIV reverse transcriptase inhibitor Sustiva. Anderson ...Biggest physics meeting of the year
...ation approach employs magnetic forces that can be directed to pull in tandem with gravity's forces to create enhanced gravity or to push in opposition to gravity to create weakened and even inverted gravity (in which the organism moves opposite to the direction of gravitational force).. These strong magnetic...You scratch my back, I'll scratch yours: Chimps point to spot they'd like groomed
...knowledge of others. Up until now, scientists saw directed scratching only in captive chimps and language-trained apes who interacted with humans, Mitani said. "The more we learn, the more we see chimpanzees employing remarkable, seemingly human-like behaviors," Mitani said. "To me that is one of the lesson...News tips from the Journal of Neuroscience
...nal evidence that embryonic stem (ES) cells can be directed to generate defined classes of motoneurons, an important general issue for successful cell transplantation. The authors treated ES cells with sonic hedgehog (Shh) ligand and retinoic acid (RA) for 5 d in culture and tracked the cells with enhanced gr...The American Association for Cancer Research provides support for promising cancer scientists
...f epithelial ovarian cancer and a target for tumor directed therapy AACR-AstraZeneca-Cancer Research and Prevention Foundation Fellowship in Translational Lung Cancer Research Recipient: Anil Potti, M.D., Duke University Medical Center, Durham, N.C. Project: Gene expression signatures of oncogenic pathway...Innovative technology for production of new pharmaceuticals forms basis of new company
...raightforward. Therefore, in the 1980s, scientists directed all their attention to the use of plant cells as production units. These plant cells can, in fact, produce the same substances as the plants themselves, but they do it much more quickly. VIB and VTT researchers make further progress The cell cultu...Driver of anthrax toxicity could lead to late-stage therapy
...rax toxicity and the demonstration that antibodies directed against the extracellular domain of LRP6 can protect cells grown in culture against killing by anthrax toxin suggest that the immunological targeting of LRP6 may prove useful in protecting against the effects of accumulated toxin during the late stag...'Custom' nanoparticles could improve cancer diagnosis and treatment
...d to stability in the bloodstream or ability to be directed toward a specific cancer site. In addition, there has been no general method available that allows precise control of the particles size, shape and composition, which are considered key features for the success of targeted drug delivery, he says. No...Taking a bite out of a fellow worker helps wasps recruit new foragers
... foragers are recruited. He found that biting was directed at certain individuals, who previously hadn't left...r workers. "The fact that biting was specifically directed at recruited foragers shows that biting is the mechanism that the colonies used to activate new fora...Lung surfactant: Host defense/surface tension, and linking innate/adaptive immune systems
...ung function and opened up a new field of research directed at understanding the role of surfactant components in reducing surface tension." Then "the dual role of surfactant in host defense evolved from the microscopic observation made by Voss and coworkers that surfactant protein SP-A was structurally homol...Salk scientist Ron Evans wins 2006 Gairdner Award for his discovery of hormone sensors
...ists had known since the early 1900s that hormones directed organ physiology, but, until Dr. Evans' discovery, they had no idea how the minute amounts of hormones produced by the body actually triggered the changes. Because nuclear receptors wield such physiological power, their discovery provided a multitude...JCI Table of Contents, April 13, 2006
...onstrates how the rational design of a DNA vaccine directed against a self antigen can generate multispecific T cell responses to otherwise non-immunogenic antigens, thereby enhancing the immune response against cancer self antigens. TITLE: Optimization of a self antigen for presentation of multiple epitopes...Movement of chromosome in nucleus visualized
...co-author of the study. It was clear that this was directed movement that required a motor, Belmont said, beca... have been able to observe an active mechanism for directed long-range chromosome movements that depend directly or indirectly on actin and myosin." Other autho...Study finds a high caloric diet may prevent the progression of amyotrophic lateral sclerosis
New York, New York A recent study directed by the Mount Sinai School of Medicine suggests a ketogenic- high caloric diet may prevent the progression of Amyotrophic Lateral Sclerosis (ALS). This study, which appears in the April 3, 2006 issue of BMC Neuroscience, is the first to draw a correla...Forsyth scientists gain greater understanding of how embryos differentiate left from right
...nimal embryogenesis. The lab's investigations are directed toward understanding the mechanisms of signaling between cells and tissues that allows a living system to reliably generate and maintain a complex morphology. The Levin team studies these processes in the context of embryonic development and regener...Viral protein helps infected T cells stick to uninfected cells
...oss the surface of the cell and form clusters when directed to do so by signals from within the cell.) "Our study is the first to show that HTLV-1 p12 not only enhances the activity of infected T cells, but that it promotes the spread of the virus from cell to cell by causing LFA-1 receptors to cluster on th...LIAI scientists make major finding on potential cure for type 1 diabetes
... which still require regulatory approval, would be directed at persons recently diagnosed with type 1 diabetes or who are already being treated for pre-diabetes. George Eisenbarth, M.D., Ph.D., Executive Director of the Barbara Davis Center for Childhood Diabetes in Colorado, called the finding "a very impo...Formation of cellulose fibers tracked for the first time
...les kept moving, but they followed different, less directed patterns. "Many scientists had suspected a relationship between cellulose synthase and microtubules, but the exact nature of the interaction was hard to pinpoint," Ehrhardt said. "The microtubules act as more than a general scaffold for organizing th...Anthrax inhibitor counteracts toxin, may lead to new therapeutics
...ly to enhance the potency of polyvalent inhibitors directed to this target and, they suggest, others. They note the work also could be useful for creating specific target recognition in biological sensors. The team says their work demonstrates for the first time that liposome-based polyvalent inhibitors are e...