NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
...lts and children diagnosed with dermatomyositis (a disease that causes muscle weakness and rash) and adults diagnosed with polymyositis, which is not associated with a rash. The study doctors want to know whether rituximab improves symptoms of these diseases. Rituximab is a monoclonal antibody used and ap...Study begins to reveal clues to the cause and progression of sepsis
...s country experienced over 50 years ago with heart disease and stroke we knew that too many people were dyin...scular disease, but we didnt know enough about the disease to effectively treat and prevent it, said Derek C. Angus, M.D., M.P.H., professor and vice chair of ...Pollution causes 40 percent of deaths worldwide, study finds
... Both factors contribute to the malnourishment and disease susceptibility of 3.7 billion people, he says. Dav... results in more soil being blown but spreading of disease microbes and various toxins. At the same time, more microbes are becoming increasingly drug-resist...Abnormal fat metabolism underlies heart problems in diabetic patients
St. Louis, Aug. 10, 2007 Heart disease hits people with diabetes twice as often as people... and often result in premature death, making heart disease the major killer of diabetic people. But why is heart disease so prevalent among diabetics? To help ...No evidence that widely prescribed statins protect against prostate cancer
...ts age, body weight, and history of cardiovascular disease and diabetes. We know that men with higher body mass index, diabetes and cardiovascular disease tend to have lower testosterone levels, and this largely accounted for the drop in testosterone in s...deCODE discovers cause of major subtype of glaucoma
...nderstood to date about the pathophysiology of the disease and there are no treatments targeting the underlying causes of the condition....OHSU turns mouse into factory for human liver cells
...y immunodeficient mouse strain that develops liver disease only when the animals don't receive a protective drug called NTBC, allowing liver disease to be turned on and off. "Our mice on this medicine are perfectly healthy, normal mice, and only w...Genetic variation helps to understand predisposition to schizophrenia
...re yet to be determined, scientists agree that the disease is in part due to genetic variations, Law says. Th...art to make sense of the underlying biology of the disease and develop improved therapies based on peoples genes, Law says. The insight gained on the Neureguli...Gilbert Foundation and American Fed for Aging Research award grants on Alzheimer's disease
...people worldwide are forecasted to have Alzheimers disease (AD), including 16 million Americans if no prevent... a prognostic tool to track the progression of the disease as well as monitor the biological effects of new therapeutic agents. Chad Antony Dickey, Ph.D., ...Antioxidant overload may underlie a heritable human disease
...ted in simpler organisms but not in mammals and/or disease states, he said. In the current study, the resea...ps of proteins. Although the genetic basis for the disease had been linked to mutations in one of two genes, the mechanism responsible remained mysterious. T...A study by the MUHC and McGill University opens a new door to understanding cancer
...th cancer and contributes to the fight against the disease by directing us towards research avenues for new medications. ...JCI table of contents: Aug. 9, 2007
...rs to conclude that heart failure is a pleiotropic disease that involves both apoptotic and necrotic cardiomyocyte death. TITLE: Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure AUTHOR CONTACT: Jeffery D. Molkentin Cincinnati Childrens Hospital Medical Cente...New test improves detection of liver cancer
...C) is the most prevalent primary liver cancer. The disease most often appears following a chronic inflammatio... implementing this test for the diagnosis of liver disease in compliance with clinical practice. The new results concerning HCC diagnosis provide an extra ince...Cardio exercise benefits in male vs. female hearts
Austin, TX While cardiovascular disease occurs in both men and women, it does not affect them in the same way. Risk factors and protective factors for heart diseases are likewise unequal. The molecular mechanisms responsible for these differences are so far unknown, but some believe it is ...Testosterone replacement therapy: How safe for aging men?
...f testosterone-supplementation in animal models of disease that mimic the characteristics of the human male population that currently receive testosterone supplements. They are currently testing the hypotheses that the natural decrease in testosterone brought on by aging may affect the progression of pre-exi...Female gender provides an advantage in renal diseases
... of many renal diseases, such as polycystic kidney disease (PKD). The physiology behind gender differences and renal disease is still uncertain, but the distinct characteristics of male and female kidney size, along with diet...Research aims to identify markers for menopausal women at risk for deadly blood clot
...t men have a higher risk factor for cardiovascular disease (CVD) than do females, and arterial clots, rather than venous clots, are a greater concern in the presence of CVD. Since men carry the female hormone estrogen as well as the male hormone testosterone, some of the findings from the female KEEPS study ...The 'female advantage' in kidney disease does not extend to diabetic women
...diabetes that predisposes a woman to develop renal disease at levels generally associated with her male count...en are infrequently diagnosed with kidney or heart disease until they reach menopause. At menopause, when their sex hormone -- estrogen -- begins to disappear ...Almac Diagnostics announces pioneering genetic research on ductal carcinoma in situ
...ntain significant additional data, relevant to the disease of interest that is not available on other generic...d ultimately deliver clinical applications in this disease setting. said Paul Harkin, BSc, PhD, Professor of Molecular Oncology at the Centre for Cancer Resear......or tissue in lung [cancer] predicts metastasis and disease progression. These findings suggest that the lung tumor and its surrounding lung environment interact, the authors write. Contact: National Cancer Institute press office, ncipressofficers@mail.nih.gov , (301) 496-6641 Loss of Imprinting in ...