NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
... effort to study a treatment for a rare autoimmune disorder called myositis, thanks to a five-year, $8 million contract from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, part of the National Institutes of Health (NIH). Chester V. Oddis, M.D., professor of medicine at the Univer...Abnormal fat metabolism underlies heart problems in diabetic patients
...d to heart problems. Interestingly, a rare genetic disorder Barth syndrome held a key to identifying cardiolipin decrease in diabetic hearts. Children born with Barth syndrome have weak hearts and often die young from heart failure. These children have mutations that prevent cells from producing enough card...Swarming starlings help probe plasma, crowds and stock market
...ly good at picking up the phase transitions from disorder to order in such complicated systems. Initially...patterns model produced the same sort of order to disorder phase transitions that would be an ideal test for their mutual information based tool. They applie...Antioxidant overload may underlie a heritable human disease
...henotype and the natural history of this inherited disorder in humans, according to the researchers. The results found in the heart suggest that reductive stress might underlie other diseases, as well. Our findings open up a whole new line of investigation in protein aggregation diseases, including neurodeg...Research aims to identify markers for menopausal women at risk for deadly blood clot
...ng deep inside the vein. Despite the fact that the disorder is rare, it increases exponentially during menopause and can be deadly. The hormone trials conducted thus far, focusing on proteins in blood coagulation, have not yet led to a risk profile, thereby precluding identification of women at risk. Now, a t...The 'female advantage' in kidney disease does not extend to diabetic women
..., they have fewer and less severe episodes of this disorder throughout most of their lives. That advantage disappears, however, when the woman is diabetic. For reasons still unclear, diabetic women -- regardless of age -- are diagnosed with kidney and heart diseases almost as frequently as men. What is i...Cornell scientists link E. coli bacteria to Crohn's disease
...ology. Crohns disease, an incurable inflammatory disorder of the intestine most commonly found in the lower part of the small intestine called the ileum affects 1-in-1,000 people in Europe and North America. Thus far, gut bacteria have long been suspected in playing a pivotal role in the development of Cr...Pregnant mothers join search for causes of autism
...ns the search for causes and early markers for the disorder during pregnancy. Who:. A participant in the ...Autism is a pervasive, lifelong neurodevelopmental disorder that causes poor verbal and communication skills, repetitive behaviors and impaired social abilities...Gene variant is associated with brain anatomy, clinical course of ADHD
...be associated with attention-deficit/hyperactivity disorder (ADHD) and with thinner tissue in areas of the brain that handle attention, but also appears associated with better clinical outcomes among individuals with the disorder, according to a report in the August issue of Archives of General Psychiatry, on...Gene predicts better outcome as cortex normalizes in teens with ADHD
...t in children with attention deficit hyperactivity disorder (ADHD) who carried a particular version of a gene in a study by the National Institutes of Healths (NIH) National Institute of Mental Health (NIMH). However, the areas, on the right side of the brains outer mantle, or cortex, normalized in thickness ...A low expression of MX2 gene exists in the white blood cells of narcoleptics
...interferons in narcolepsy. Narcolepsy is a sleep disorder that causes people to fall asleep uncontrollably during the day. It also includes features of dreaming that occur while awake. Other common symptoms include sleep paralysis, hallucinations and cataplexy. About one out of every 2,000 people is kno...Penn researchers discover pathway that eliminates genetic defects in red blood cells
...a form of anemia, which is the most common genetic disorder worldwide. The results appear in the most recent issue of Nature Structural and Molecular Biology. Cells have developed surveillance mechanisms that identify and destroy abnormal RNAs. Mistakes in a cells reading of RNA into protein can lead to ...JCI table of contents: August 1, 2007
...n brain damage. Hypomagnesemia can be an inherited disorder and mutations in any one of a number of genes have been shown cause the disorder. A new study in the August issue of the Journal of Clinical Investigation has now added the EGF gene to this list and identified why one mutation in this gene causes hyp...First case of successful ovarian tissue transplantation between two, nonidentical sisters
...sa Alvaro for beta-thalassemia an inherited blood disorder characterised by reduced or absent haemoglobin, which is the oxygen-carrying protein in red blood cells. She received chemotherapy and radiotherapy before having a bone marrow transplant from her 17-year-old sister, Sandra Alvaro, who had an identica......eders and owners are hoping to eradicate a genetic disorder causing a lethal fragile skin condition among some... Dermatosparaxis is an inherited connective tissue disorder attributable to abnormal collagen in the skin which causes extreme skin fragility. Normal collagen p...New databases put wings on search for bipolar risk genes
...ore than 5,000 people with bipolar illness, a mood disorder commonly marked by alternating bouts of depression...database describes the clinical picture of bipolar disorder in the fullest detail possible, says James Potash, M.D., who led the Hopkins portion of efforts to a...Reading a face is tricky business
...ric disorders such as phobia, obsessive-compulsive disorder and generalized anxiety disorder, said Wen Li, lead author of the study and postdoctoral fellow at Northwesterns Feinberg School of Medicine. Neural and Behavioral Evidence for Affective Priming from Unconsciously Perceived Emotional Facial Expres...Huntington's disease study shows animal models on target
...n incurable and fatal hereditary neurodegenerative disorder caused by a mutation in the gene that encodes the huntingtin protein. Neurons in certain regions of the brain succumb to the effects of the altered protein, leading to severe motor, psychiatric, and cognitive decline. Several recent studies have show...Stem cell therapy rescues motor neurons in ALS model
...hic lateral sclerosis (ALS), a fatal neuromuscular disorder also known as Lou Gehrig's disease. The new work, conducted in a rat model and reported today (July 31) in the online, open-access journal from the Public Library of Science, PLoS ONE, shows that stem cells engineered to secrete a key growth factor...After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis
...ion, and is the most common disabling neurological disorder of young adults. It's an autoimmune disease, occurring when the body's immune system mistakenly attacks a protective sheath around axons the delicate cables that nerve cells use to connect with each other. Various immunosuppressant drugs can reduc...