Toward a better understanding of taste and smell impairments
... related to the impact of inflammation on clinical disruption of smell and taste function: One project, headed by cellular biologist Nancy Rawson, Ph.D., will study chronic rhinosinusitis (CR), one of the most common chronic medical conditions in the United States and one of the most significant causes ...Technique for genetically modifying blood stem cells brings cure for blood diseases closer
...ome and disrupt it. "When it comes to avoiding disruption of chromosomes while improving the efficacy of a single gene used to modify a cell, less is definitely more," Persons said. In the experiment, mice that received transplants of stem cells modified with mLar-beta-delta-gamma-V-...Children's Hospital Boston geneticist awarded for research on muscular dystrophy
...cs of several dystrophin-associated proteins whose disruption also leads to muscular dystrophy. Today, Kunkel continues to explore the role of these proteins and the more than 40 genes that have now been linked with various muscular dystrophies. His lab is using microarray (gene chip) technology to systematica...Clues to the puzzle of 'talking' root cells
...t the mutated protein can't move because there's a disruption in some interaction that facilitates movement." While the latest finding represents only the earliest hints of a mechanism by which the protein moves from cell to cell, it offers a promising pathway for further exploring that machinery, said B...Gene found to defend against environmental pollutants and pulmonary emphysema
...ural defense mechanism. The researchers found that disruption of the Nrf2 gene caused earlier onset and more severe emphysema in a strain of mice that is resistant to cigarette smoke-related emphysema.Through gene chip analysis, the researchers were able to identify 50 Nrf2-dependent antioxidant and cytoprotect...Sleeping, waking, ... and glucose homeostasis
...wever, if this is a behavioral effect, whereby the disruption of the SCN might alter our feeling of being well f...is whether the change in glucose that results from disruption of the Clock and Bmal1 genes is due to the transcription factors' effect as circadian regulators or ...Global warming's impact on US plants, animals determined from review of dozens of studies
... toward a fundamental and potentially irreversible disruption of the U.S. landscape and wildlife," said Eileen Claussen, president of the non-profit Pew Center on Global Climate Change in Arlington, Va. A 2001 report from the Intergovernmental Panel on Climate Change involving Parmesan concluded that human use ...Studies suggest promising new directions for gallstone treatment
... trace of the disease." Gallstones are formed by a disruption in the normal balance of bile acids and phospholipids that are pumped from the liver into the gall bladder. Bile then becomes supersaturated with cholesterol, which is still being pumped into the bile under control of another metabolic pathway. This ......ation in the same gene, previously associated with disruption in wing formation in fruit flies, increased levels of the Lmo protein and decreased response to cocaine. Thus, they concluded that Lmo appears to play a central role in regulating cocaine sensitivity. The researchers suggested that because Lmo-...A new species of amyloid peptide
...on of cell death programs, oxidation of lipids and disruption of cell membranes, an inflammatory response, and possibly neurofibrillary tangle formation, which is a close correlate of neuron loss. Therefore, the problem of production, accumulation, and clearance of amyloid β-peptide in the brain emerges as...Discovery of first demethylase molecule, a long-sought gene regulator
...ctivity that determine normal cell function. Their disruption can lead to cancer. The elusive enzyme, whose presence in cells was suspected but not proven for decades, came to light in the laboratory of Yang Shi, HMS professor of pathology, and is described in a study published in the Dec. 16 online edition o...Report assesses health implications of perchlorate ingestion
...rs in humans. Humans are much less susceptible to disruption of thyroid function or formation of thyroid tumors than rats, and therefore the way rats responded to perchlorate exposure is not a good indicator of how humans would react. In the past, high doses of perchlorate were used to treat patients with hype...New insight into regulation of blood stem cells
...ave been difficult to study using traditional gene disruption methods because loss of genes thought to be critical for this process often results in embryonic death, making it impossible to study the role of the gene of interest in mature animals. Dr. Michael P. Cooke and colleagues from the Genomics Institute...Story tips from the Department of Energy's Oak Ridge National Laboratory, February 2005
... isotope ratios that indicate a major global-scale disruption of geochemical cycles. This research, published on the Science Express website Jan. 20, was performed while Turgeon was with the University of Oldenburg in Germany. [Contact: Ron Walli, 865-576-0226; wallira@ornl.gov ] GENETICS -- Biosystems approa...Nobel laureates to open ASBMB annual meeting in San Diego
... regulating cholesterol metabolism and its genetic disruption in the human disease familial hypercholesterolemia have been recognized by their receipt of numerous awards, including the Albert D. Lasker Award in Basic Medical Research (1985), the Nobel Prize in Physiology or Medicine (1985), and the U.S. Nationa...Childhood deficits in the cerebellum may be linked to adult alcoholism
...ated with alcohol intoxication is largely due to a disruption of cerebellar function. Long-term heavy drinking can also cause progressive degeneration of the cerebellum for some alcoholics. Defects in the cerebellum itself, however, have never been considered as a potential cause of alcohol dependence. In a ...South America's vast pantanal wetland may become next everglades, UNU experts warn
...as led to increased erosion and sedimentation, and disruption of the local hydrologic pattern. This has made navigation difficult and also hindered waterfowl and fish migration." Local cattle raising in the Pantanal has declined due to competition from highland cattle breeding where pastures may be used all ye...Earth's services in peril, report concludes
... greater poverty results. The impact of ecosystem disruption often falls first and most heavily on the poor, while wealthier economies can afford some engineered solutions that at least temporarily forestall the crisis. "We hear a lot about various environmental problems and ecological issues, but this report...Statins, other cholesterol depletors, may disrupt hypertension development: UCSD study
... which blocks cholesterol synthesis, resulted in a disruption of the caveolae and reduced the amount of calcium that entered the cells. "Additionally, these two treatments also decreased the growth rate of the diseased cells," Patel said. Taken together, the results "mean that the micro-structure of the cell ...Society of Nuclear Medicine offers program to meet patients' current, future needs for radionuclides
...tions every day are imported on a daily basis, and disruption of their availability threatens to interrupt tens of thousands of nuclear medicine procedures each day. Those radionuclides required for innovative research are either available only sporadically and in limited quantities or not available at all. New...