On the defense: Conserved features of plant innate immunity
...Arabidopsis remains a very robust genetic tool for dissecting processes in multicellular eukaryotes, with relevance to the realm of human biology. To our knowledge, this is the first placement of the NTC into a known signaling pathway in any organism. We are continuing to find commonality between animal and pla...Study pries into ovarian cancer's deadly secrets
...t, Cho plans to tackle the "very big challenge" of dissecting the molecular basis of serous ovarian cancer, the most common form of ovarian cancer and the one responsible for most ovarian cancer deaths. That work, combined with ongoing projects on ovarian endometrioid adenocarcinoma, could help researchers de...JCI table of contents -- April 5, 2007
...y to deteriorating heart function requires further dissecting to determine more fully its role in development and disease before it can be considered as a target for the development of treatments to prevent heart failure as a result of cardiac hypertrophy. TITLE: Modulation of adverse cardiac remodeling by ST...NJIT awarded $1.1M NSF grant to change way inner-city students learn
... 9-15 hands-on sophisticated projects ranging from dissecting a cow's eye to building suspension bridges out of popsicle sticks. FEMME, as all NJIT summer programs do, makes difficult math and science concepts relevant, memorable and fun. ...Motor protein plays key role in connecting neurons
... they will form a synapse," says Dr. Xiong, who is dissecting how neurons first connect with the goal of helping restore communication lost in spinal cord injuries and other disorders. "Growth is precisely controlled during development," she says and errant growth can impair brain wiring or connectivity. "My...Getting to the bottom of memory
... approach allowed them for the first time to start dissecting the molecular basis of LTP while simultaneously addressing effects on learning and memory. Using genetic methods they generated mouse strains with a defective version of a receptor molecule called TrkB. TrkB is found on the surface of cells in the hi...Worms produce surprise insight into human fever
...ent microbial colonization of the intestine. In dissecting two conserved pathways required for C. elegans immunity to bacteria, Aballay found a wealth of data on innate immunity plus a surprising insight into another classic metazoan response to infection fever. The first pathway was p38 MAPK/CED-3, which...Genetic map offers new tool for malaria research
...orldwide. These differences lay the foundation for dissecting the functions of important parasite genes and for tracing the global spread of malaria. Led by scientists at the Harvard School of Public Health and the Broad Institute of MIT and Harvard, together with researchers in Senegal, the work has already un...... in an incubator. The researchers used a dissecting microscope to count the number of live and dead lice from each side of the scalp. They re-examined them up to 18 hours later to make sure all were dead. Nits were incubated for two weeks to see how many hatched. "Effectiveness of the differ...MIT engineers probe spiders' polymer art
... with furry knuckles." But he quickly settled into dissecting the peanut-sized and -shaped protuberance on the spiders' backs containing their silk-producing glands and spinnerets. Spiders don't actually spin ("spinning" refers to the age-old art of drawing out and twisting fibers to form thread); instead, the...Leveling the field for babies with persistent pulmonary hypertension
... deprived of critical oxygen and glucose. They are dissecting the no-doubt, complex chain of signaling that leads to neuronal death in babies and looking for viral delivery systems that can help protect brain cells....FSU scientist's biomolecular research published in Science, Nature
... analogous, although at quite different scales, to dissecting the human heart in order to understand how it works and its role in blood circulation. It is still quite challenging to obtain structures of novel biomolecules, and it is even more challenging to capture the structure of "molecules in action." The se...Glycoprotein hormone receptors
...untry we have aspired at understanding and further dissecting the molecular mechanism of activation of the Glycoprotein hormone receptors (GpHr), members of the G protein coupled receptor (GPCR) superfamily. First, we have focused on a network of polar interactions among highly conserved residues within the tra...Low-level exercise delays heart failure, markedly extends lives, even with hypertension
...scribed in this work may ultimately be of value in dissecting out the specific cellular and molecular processes that are influenced by training and that are required for improved survival in a setting of developing heart failure," the paper concluded. Next steps Moore said the experimental results "are only ...Novel plague virulence factor identified
...treated. "Dr Aballay has developed a new model for dissecting the ways pathogens such as the plague can infect and kill their hosts," said Pamela Marino, Ph.D., scientist at the National Institute of General Medical Science. "This creative approach should improve our ability to develop new medicines to treat su...The doctor is in: UH engineering students find medical mentors
...f the mentors' projects and how each researcher is dissecting his or her problem. The mentors give the first lectures, but the students conduct the final portion of the sessions, explaining their objectives and detailing the work they've accomplished. "Another advantage of the program is the students' experi...Earliest embryos ever discovered provide clues to dinosaur evolution, parenting: Study
...he specimen for a year, using a 100X magnification dissecting microscope and miniature excavating tools. "Diane worked on a steel slab on top of bubble wrap so as not to feel outside vibrations," says Reisz. "Even a door slamming could affect her work." Experts in the field hailed the study as a significant co...Eliminating bacterial infections out of thin air
...mmentary, Kol Zarember and Harry Melach write, "By dissecting the role of HIF-1 in innate immune defenses, the studyintroduces new targets for therapeutic immunomodulation."......mmentary, Kol Zarember and Harry Melach write, "By dissecting the role of HIF-1 in innate immune defenses, the studyintroduces new targets for therapeutic immunomodulation." TITLE: HIF-1alpha expression regulates the bactericidal capacity of phagocytes AUTHOR CONTACT: Randall Johnson University of California, S...... analysis provides an important starting point for dissecting of function and evolution of small RNAs and their targets....