Two-part blood pressure control suggests new approach to hypertension therapy
...e that the kidneys and other systemic tissues have distinct and equally important roles in controlling blood pressure. The researchers report their findings in the April 1, 2005, issue of the Journal of Clinical Investigation . The findings provide new insights into how the kidney interacts with other organs...Automated imaging screen reveals promising drug candidates
...wn kinase inhibitor, induced morphological changes distinct from any known kinase inhibitor. What does hydroxy-PP target? An enzyme, called carbonyl reductase 1 (CBR1), that acts on xenobiotics like anticancer drugs and is thought to cause the heart damage associated with daunorubicin chemotherapy. The author...Ebola virus: from wildlife to dogs
...e virus involved many contamination events between distinct animal species. Thus, the multiplicity of infected species, their different susceptibilities to the virus and the great differences in their ways of life, are indicators of the complexity of Ebola virus's circulation in its natural environment. These...An (ecological) origin of species for tropical reef fish
...ations mutate independently until individuals from distinct populations can no longer interbreed and become ne...rt along the Brazilian coast were genetically more distinct than were fish collected 4200 km apart, from Fernando de Noronha island off of the Brazilian coast a...Human chromosomes 2, 4 include gene deserts, signs of chimp chromosome merger
... rather than randomly and appear to arise from two distinct underlying patterns. They then checked the regions in the chimp genome. "In general, they were also highly variable in chimps," Hillier says. "It's going to take a lot more work to figure out what's going on in these regions, but some of these occur...Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia
... resistance to two widely used and mechanistically distinct antileukemic agents and provided new information about the cellular mechanisms involved in disparate response to these drugs. Specific genetic signatures related to ALL treatment failure and chemotherapeutic cross-resistance were more effective at i...Readers of genome decipher signatures of cancer patient outcomes
...of these regions, the unstable and stable, display distinct genetic signatures. What's more, the unstable microsatellite version of genes was associated with longer survival. "It was previously shown that patients with stage II MSI tumors had a better prognosis than stage II MSS tumors, and that all stage III...Whale bones and farm soil: Sequencing biodiversity
...robial environment that can contain more than 3000 distinct species (most of them bacterial) in a half-gram sample. The scientists started by sequencing hundreds of thousands of genes from each sample the DNA equivalent of about 50 complete bacterial genomes. This data was then complemented by two recently p...Study finds enzyme activity promotes rare form of leukemia, offers potential target for new drugs
...somal translocation, a breaking and joining of two distinct chromosomes, that creates a hybrid gene. The product of the hybrid gene is called a "fusion protein," meaning that the newly formed gene encodes a protein made of fragments from each of the two genes that were fused together by the rearrangement. So...DNA solves mystery of Gibraltar's macaques
... was founded with individuals from two genetically distinct populations in Algeria and Morocco." Key to study:...rian and Moroccan populations are genetically very distinct and that there are major genetic differences even within Algeria," Modolo said. "Mixing of founders ...ASU researcher creates novel 'bioelectronic signatures' to detect DNA mutations
...tals were selected owing to their ability to yield distinct electronic signatures, with four well-resolved current peaks. Next, the nanocrystals are piggybacked onto individual DNA bases; these DNA bases each carrying a single nanocrystal bind to a DNA sample and cause minute electrical current changes in t...JCI table of contents June 1, 2005
...en, to induce two functionally and morphologically distinct forms of programmed cell death in endothelial cells. One pathway is classical apoptosis and the other is an apoptotic-like pathway mediated by bacterial toxins. This study advances our understanding of bacteria-induced cell death and provides insig...3-D study of immune cell interactions reveals details of an effective antibody response
...ferent organs of the body, T and B cells travel to distinct regions in the spleen and lymph nodes - B cells amassing in follicles and T cells in T zones - in search of alien antigens. Upon encountering antigens, B and T lymphocytes migrate to the edges of their respective zones and compare notes. In the study...Killer dinosaurs turned vegetarian
...n China and Mongolia, but were not recognized as a distinct group until about 25 years ago, Sampson says. The only therizinosaur known previously from North America was Nothronychus, which Kirkland discovered in the late 1990s in New Mexico. It was 90 million years old, so scientists initially believed the ......s and organs. But dividing and changing shape, two distinct processes, cannot happen simultaneously. Directing activities so each takes place in turn becomes critical when the pressure is on to do both. A team of Weizmann Institute scientists recently found how a cellular "traffic cop" temporarily halts cell ......either a high- or low-frequency tone or one of two distinct patterns). A delay period followed these cues. If a forget cue was presented, the trial ended after the delay, and no memory test was given. If the remember cue was presented, the birds were given a memory test in which they saw two stimuli after th...Fat's fate depends on its source
...e, lipid, and cholesterol metabolism by activating distinct pools of PPARa in the liver. Further study is required to elucidate the mechanism by which nutrient sensors in the body distinguish between different sources of fat, the researchers said....Scientists discover odd-ball rodent
...dents millions of years ago. "To find something so distinct in this day and age is just extraordinary. For all we know, this could be the last remaining mammal family left to be discovered," Dr. Timmins said. Very little is known about the Kha-Nyou, other than it seems to prefer areas of limestone outcroppin...Gene 'archeology' gets easier using Carnegie Mellon University software
... so that it becomes a highly organized tree with a distinct root and a clear, concise history of duplications. (See illustration.) "These parsimonious trees give us the simplest possible explanations for how a gene evolved, and simpler is usually better," Durand said. Durand is collaborating with a team at ...