Yale scientist studying virus infections named Burroughs Wellcome Investigator
...antigen presenting cells during viral infection in distinct mucosal tissues, the genital tract and the lung. "We hope that our study will lead to the identification of factors that stimulate the immune response and that would be effective at the site of natural virus entry," said Iwasaki. "Ultimately we woul...Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage
... the T-cell antigen receptor complex, or TCR." Two distinct lineages of T cells utilize distinct types of TCR complexes. One lineage employs pairs of TCR proteins termed alpha-beta while the other...Scripps scientists find potential for catastrophic shifts in Pacific ecosystems
... with "nonlinear" mechanisms. Measuring regimes as distinct from random wiggles in oceanographic time series has been elusive until this study. The biological shifts are more than random wiggles. On the contrary, and to their surprise, the researchers found that some key physical characteristics of the North...Gene keeps neural cells on correct developmental path
...rvous system development by removing REST in three distinct phases, ending with shutting down the REST gene. "The cell gets rid of all the excess protein, kicks it off the DNA, then stomps on its head so it can't make RNA," Mandel said. "We can't detect REST in the terminally differentiated neuron." But some...Tracking a killer: Observing liver invasion by malarial parasites
... which have a complex life cycle involving several distinct phases and habitats. But, many details of the orga...es traversed Kupffer cells using a special process distinct from ordinary parasite locomotion. Upon exiting the Kupffer cell on the other side, the sporozoit...After a time-shift, mixed signals from the circadian clock
...d by a ventral (lower) group of cells, exhibited a distinct pattern of activity that corresponded to fast resetting of the clock. Perhaps contributing to the different behavior of the two groups of clock cells are the effects on these cells of the neurotransmitter GABA, which the researchers found to excite t...Scientists journey to southern Africa to unravel the secret world of elephant communication
...es to see if the elephants could recognize them as distinct vibrations. "We wanted to determine if they can discriminate between familiar and unfamiliar calls that are played back as seismic signals," O'Connell-Rodwell explains. To record the elephants' reactions, she and her colleagues buried an array of 22 ...Edible bivalves as a source of human pathogens: signals between vibrios and the bivalve host.
...h components and the ability of bacteria to affect distinct signaling pathways responsible for the hemocyte immune response. Laura Canesi, from the University of Urbino adds "In bivalve hemocytes, different Vibrio species and strains seem to adopt a common strategy utilized by pathogenic bacteria in mammali...Decoding the logic of olfaction
... fish, urine, musk, and chocolate. Revealing these distinct but often overlapping patterns of neural activity represents a significant step in understanding how the brain translates complex signals from odorant receptors in the nose into odor perception in the brain, the researchers said. The research team,...Leprosy microbes lead scientists to immune discovery
...n as monocytes rapidly differentiated into the two distinct cell types, forming the body's emergency response to the detection of foreign bacteria. One category of defensive cells, macrophages, seek out and engulf the infectious bugs. The other group consists of dendritic, or "antigen-presenting" cells, which...Employee with sleeping disorder has to work extra hard
...logists, do not consider sleeping problems to be a distinct disorder. Consequently they often fail to choose right treatment and do not refer the patient to a sleeping disorder centre on time.......ing zebrafish development. The authors cloned 154 distinct miRNAs (10 of which are completely novel) in a developmental and tissue-specific manner. They also identified for the first time ever in a vertebrate a new class of small RNAs, called repeat-associated small interfering RNAs. Because of the importa...Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
...onding, or attachment. "Humans have evolved three distinct but interrelated brain systems for mating and reproduction the sex drive, romantic love, and attachment to a long term partner," Fisher said, "and our results suggest how feelings of romantic love might change into feelings of attachment. Our result...Yale scientists identify structure for RNA quality control
... RNAs. "The crystal structures of Ro revealed two distinct RNA binding sites, one of which recognizes misfolded small RNAs. Unlike most proteins, Ro has a hole through the middle - and the hole is used in distinguishing these RNAs," said Reinisch. Mothers with anti-Ro antibodies often have babies with heart ...Eleven gene 'signature' reliably predicts cancer prognosis
...fter therapy in cancer patients diagnosed with ten distinct types of cancer. This work indicates that the presence of the conserved BMI-1-associated gene expression pathway that exists in a very malignant subset of human cancers predicts a marked predisposition toward metastasis and a high probability of poo...JCI table of contents June 1, 2005
...fter therapy in cancer patients diagnosed with ten distinct types of cancer. This work indicates that the presence of the conserved BMI-1-associated gene expression pathway that exists in a very malignant subset of human cancers predicts a marked predisposition toward metastasis and a high probability of poo...JCI table of contents July 1, 2005
...ese T cells retain their nave phenotype and remain distinct from Treg cells. This is the first demonstration of this new subset of T cells with a potentially important role in T cell activation and proliferation. Title: In Vivo Expansion Of CD4+/CD45RO-/CD25+ T Cells Expressing FoxP3 In IL-2 Treated HIV In...From memory formation during sleep to novel components for physics
...e that the memory-forming processes in these three distinct regions are controlled by a single higher-level control system during sleep and are at least partially based on the same mechanisms. The findings will also be used to study selected groups of patients directly in a clinical setting. (Spokesperson:...European funding for research on biomolecular nanomachines
...nanomachines are constructed from proteins but use distinct mechanisms for force generation. Filaments are rod...turing seems rather appealing in order to assemble distinct molecular components into integrated nanosystems with a complex supramolecular architecture....Georgia Tech develops mass spectrometry device that analyzes proteins faster and at a lower cost
...t carry out these plans. There are about 2 million distinct proteins in the human body. That's a lot of proteins and the future of personalized medicine depends on a better understanding of proteins, including their structure and interactions with drugs and medical devices. Researchers at the Georgia Institu...