News tips from the Journal of Neuroscience
... RNAs for C1qb, C3, and C4 were upregulated in the dorsal horn of the spinal cord after injury and were expressed only in microglia. The complement cascade culminates in C5 and C5a receptor (C5aR) activation and formation of the membrane attack complex (MAC). Both C5 and C5aR were upregulated dramatically a...News tips from the Journal of Neuroscience
...the central as well as the peripheral process of a dorsal root ganglion (DRG) neuron. This conditioning effe...T mice extended axons into the spinal cord after a dorsal column injury, but axons in ATF3 transgenic mice did not. Similarly, ATF3-expressing neurons were un...News tips from the Journal of Neuroscience
... after purified Schwann cells were cocultured with dorsal root ganglion (DRG) neurons. The expression was greatest prior to myelination. Using Campenot chambers, the authors report that BDNF was secreted from the compartment containing DRG axons as well as the cell body compartment, consistent with anterogr...Study provides new data about the laws governing embryo development in organisms
...d which enable the symmetrical construction of the dorsal and ventral parts starting from a given limit or border. This process of subdivision into compartments also takes place during the formation of the vertebrate central nervous system, and the genes and signalling pathways involved are conserved in bot...News tips from the Journal of Neuroscience
... Robo1/Robo2, one branch consistently overshot the dorsal entry zone (DRZ) and prematurely grew into the spinal cord. This defect apparently arose from loss of negative or repulsive signaling by DRZ-expressed Slit acting on Robo receptors on sensory neurons. The Noise in Eye Movements Javier F. Medina...JCI table of contents: June 14, 2007
...t TRPA1 and PAR2 are significantly co-expressed in dorsal root ganglion neurons in rats and that PAR2 activation potentiates TRPA1 activity, resulting in the amplification of the pain sensation. They go on to show that this signaling pathway is dependent on the presence of the enzyme phospholipase C. The re...News tips from the Journal of Neuroscience
...ricted to lamina I and II. To target axons after a dorsal rhizotomy, Tang et al. used adenovirus to overexpress NGF in the dorsal spinal cord of rats. Three days later, they used more ventral injections to express the repellant gu...News tips from the Journal of Neuroscience
...cone dynamics. The authors treated embryonic chick dorsal root ganglion (DRG) neurons with laminin, which caused rapid reorganization of microtubules in growth cones as well as dynein staining that was concentrated at the leading edge. Dynactin and LIS1 were colocalized with dynein. A similar staining patte...News tips from the Journal of Neuroscience
...lar DA release in striatal slices, particularly in dorsal striatum. Exercise also decreased striatal DA transporter and tyrosine hydroxylase immunoreactivity in MPTP-lesioned mice....News tips from the Journal of Neuroscience
...of plexinA3 mRNA caused abnormal axon branching of dorsal and ventral motor nerves, and induced exit from posterior segments of the spinal cord at additional exit points. Overexpression of plexinA3 mRNA, which did not bind the morpholino, rescued the phenotype. Branching and exiting were exacerbated by coi...News tips from the Journal of Neuroscience
...cused on prenatal development. In Arx mutants, the dorsal striatum was diminished and lacked cholinergic and GABAergic interneurons; the dorsal striatum was even more severely affected. In the mutants, radial and tangential migration from LGE a...News tips from the Journal of Neuroscience
...ier et al. examine the interaction of M-current in dorsal root ganglion (DRG) neurons with a member of a G-protein-coupled receptor family that is specifically expressed in sensory neurons. The Mas-related gene (Mrg) product, MrgD, is expressed only in nonpeptidergic, small-diameter nociceptors. Using the M...New species declared: Clouded leopard on Borneo and Sumatra
...ithin the cloud markings, grayer fur, and a double dorsal stripe. Clouded leopards from the mainland have la...ency toward tawny-colored fur and a partial double dorsal stripe. Who said a leopard can never change its spots? For over a hundred years we have been loo...Prefrontal cortex loses neurons during adolescence
...ned stable in the ventral PFC and increased in the dorsal PFC. These findings challenge current models of brain development by showing that some parts of the brain are still being organized well after puberty. This could have implications for understanding human psychopathologies, such as schizophreni...When your brain talks, your muscles don't always listen
...scale in the index finger, specifically, the first dorsal interosseous muscle. Located between the index finger and the thumb, this muscle contains 120 "motor units"--in other words, 120 individual neurons, or nerve cells, and the muscle fibers they activate. "It's a relatively simple muscle, so you get t...News tips from the Journal of Neuroscience
...es under the control of the gfap promoter. After dorsal hemisection of the spinal cord, corticospinal trac...ut motor function was not improved. However, after dorsal rhizotomy, axons of sensory neurons grew back through the dorsal root entry zone and into the CNS a...News tips from the Journal of Neuroscience
...k's Journal , Fetsch et al. probed neurons of the dorsal subdivision of the medial superior temporal area (MSTd), a possible integration station for these signals. They asked: what is the spatial reference frame for signals represented in MSTd? The authors used a three-dimensional virtual reality system in...News tips from the Journal of Neuroscience
...ing. The authors expressed mutant MFN2 in cultured dorsal root ganglion neurons. Fragmented mitochondria clustered in cell bodies and proximal axons of these neurons. Time-lapse fluorescence imaging revealed disrupted mitochondrial trafficking, although ATP production and mitochondrial oxidative function re......imals do not show long-distance regeneration after dorsal hemisection, indicating that the injury-induced axonal growth varies with fiber tract and lesion paradigm. 3. Timing in the Substantia Nigra Marjan Jahanshahi, Catherine R. G. Jones, Georg Dirnberger, and Christopher D. Frith Timing is everything...... body tissues, including white blood cells and the dorsal root ganglia a group of nerve cells near the spine and involved in pain transmission. The new study showed alpha9alpha10 nicotinic receptors provide a previously unknown route to pain relief. McIntosh says a patent is pending on this new mechanism...