Tag: "dose" at biology news
Study: Eat leafy green veggies to help prevent cataracts
...as well as initiating cataract disease. "The dose
of UVB radiation we used on the cells is about the same amount a person receives when they get a mild tan," Bomser said. Adding lutein and zeaxanthin to the cell cultures provided double the protection from UVB damage these antioxidants red...
Read your shampoo's label: Study finds common ingredient stunts developing neurons of rats
...ure at a high concentration roughly 100 times the dose
used in their current study was lethal to these cells. To understand what effect chronic exposure would have on immature, developing neurons, the researchers kept cells in a media solution containing low concentrations of MIT for 18 hours. In a sta...
New drug sidesteps Gleevec resistance in human trials
...als evaluate drug safety and toxicity at different dose
levels in a small number of volunteers. "Our study examined patients in all phases of CML, including the chronic phase, the accelerated phase, and blast crisis. The patients responded quite well to this new compound, and we observed no side effects,"...
Alfred Sommer awarded prestigious Pollin Prize
...is theories and later documented that a large oral dose
of vitamin A, costing a few pennies, was a more ef...tamin A deficiency than injections. Today the oral dose
is the recommended standard of the World Health Organization (WHO) and the control of vitamin A defi...
Potent anticancer drug increases function of axons in mouse model of neurodegeneration
...ice weekly injections of Paxceed at a high and low dose
for 12 weeks. At both doses, more protein traveled down the spinal axon and the density of microtubules was greater in the Paxceed-treated mice. The drugs also reduced motor impairment in the tau transgenic mice. Because microtubule-binding drugs suc...
Component of plastic stimulates growth of certain prostate cancer cells
...o note that our study demonstrates that the actual dose
of BPA exposure may change the biological response," Dr. Knudsen said. The safety of BPA has been under intense debate for several years, with some arguing that exposure to the chemical among humans is safe, with others contending that it may promote...
'Old-fashioned' gonad capsule simple and effective for blocking radiation to testes from MDCT scan
... without. The researchers found that the radiation dose
to the testicles of the 34 who used the gonad caps...quality has meant a dramatic increase in radiation dose
to the patient," said Christian Hohl, MD, lead author of the study. "There are several attempts to ...
FDA approves ABRAXANE(TM) for metastatic breast cancer
...omized trial was designed to compare ABRAXANE at a dose
of 260 mg/m2 given as a 30-minute infusion without...Symposium in December 2003). Despite a 50% higher dose
of chemotherapy infused over 30 minutes without premedication for hypersensitivity, ABRAXANE was wel...
Lynn Sage Comprehensive Breast Center plays role in newly approved breast cancer drug, ABRAXANE
...el) can be delivered into the body at a 50% higher dose
over 30 minutes. This contrasts with Taxol in which paclitaxel is dissolved in the toxic solvent Cremophor-EL, requiring premedication with steroids and anti-histamines to avoid hypersensitivity reactions and must be given using infusions of up to t...
Blood test shows promise as monitor for antiangiogenic cancer therapy
...e exploited to help establish the optimal biologic dose
of such drugs," offers Dr. Kerbel. Yuval Shaked, Francesco Bertolini, Shan Man, Michael S. Rogers, Dave Cervi, Thomas Foutz, Kimberley Rawn, Daniel Voskas, Daniel J. Dumont, Yaacov Ben-David, Jack Lawler, Jack Henkin, Jim Huber, Daniel J. Hicklin, Ro...
Report assesses health implications of perchlorate ingestion
...raft risk assessments, each containing a reference dose
upon which a standard could be based. Controversi...ent, published in 2002, proposes a daily reference dose
of 0.00003 milligrams per kilogram (mg/kg) of body weight, which the agency said would correspond to...
Green tea extract boosts exercise endurance 8-24%, utilizing fat as energy source
...ty, no marked effects were observed after a single dose
of GTE, suggesting that some biochemical changes induced by habitual GTE intake, such as up-regulation of muscular beta-oxidation, contributed to the improvement in endurance capacity." The study found that plasma NEFA (non-esterified fatty acid) mea...
MRI 'excellent choice' for overcoming challenges of diagnosing pregnant women with abdominal pain
... for diagnosing abdominal pain, but a considerable dose
of radiation is conferred to the fetus and can increase cancer risks in both the fetus and the mother. Sonography, which is safe from radiation, is limited in what it can reveal for diagnosis. "The most compelling aspects about using MRI for evaluati...
Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
...second group of these rats was injected with a low dose
of lipopolysaccharide (LPS), a bacterial component that causes flu-like symptoms,. This time, the rats infected with E. coli as newborns froze 70 percent less often than the rats who'd been injected with salt water as newborns. In other words, unde...
Gene therapy for Parkinson's disease moves forward in animals
...ations of L-dopa levels, a continuous, therapeutic dose
would be better for you. As for efforts to reverse impaired movements in rats, scientists used 33 animals with severe dopamine depletion and transferred a gene to provide a source of L-dopa production into the animals' striata. Before receiving the ...
JCI Table of Contents, March 1, 2005
... Researchers gave 19 individuals with CLL a small dose
of heavy water every day for 84 days, and the tagg...eys damaged by ischemia and toxins. When a single dose
of siderocalin was administered to the proximal tubule in the early stages of kidney disease, it blo...
Scientists disprove two tenets of common leukemia
... The researchers gave individuals with CLL a small dose
of heavy water -- about two ounces -- every day over the course of 12 weeks, enough time for the cells to incorporate a sufficient amount into their DNA. From blood samples, they calculated the birth and death rates of leukemia cells. They found that...
The very unexpected life and death of a leukemic cell
... Researchers gave 19 individuals with CLL a small dose
of heavy water every day for 84 days, and the tagged water was incorporated into the DNA of the leukemia cells. This provided the researchers a way to track the cell division, or "birth" of new leukemia cells. Chiorazzi and his team calculated birt...
X-rays have become laser-like
...orded with far higher resolution at vastly reduced dose
levels, allowing early-stage cancer diagnosis at dramatically reduced risk. Microscopes furnished with this source would make nanometer-sized biomolecules perceivable in their natural surrounding (in vivo). It may take many years before this dream co...
Stockpile bird flu vaccine now
...it is possible to do safety tests and work out the dose
needed to produce an immune response. Clinical trials of limited batches of H5 vaccine, based on the strain now circulating in Asia, are about to start in the US and are planned in Canada, Australia and Japan, all with government funding. Because the...
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