Muon opportunists: Detecting the unseen with natural probes
... vehicles and cargo containers, with no artificial dose of radiation involved, according to the Los Alamos researchers. Truck drivers could remain in their vehicles while the scan is underway. "We measure the angle of a muon coming in and the angle going out," said Christopher Morris, a member of the Los ...Topical treatment shown to inhibit HIV and herpes simplex virus infection
...hour after administration of a single intravaginal dose of PRO 2000 gel or a matched placebo gel. CVL specimens were tested for their ability to prevent HIV and HSV infection of susceptible human cells in culture. Levels of inflammatory cytokines were also measured as markers of acute inflammation. A...It's not all genetic: Common epigenetic problem doubles cancer risk in mice
...eden and Japan has discovered that having a double dose of one protein is sufficient to change the normal ...ghly 10 percent of people have this double protein dose as well. In the Feb. 24 online version of Science , the researchers report that mice engineered to ...... a drug in development is likely to work and which dose is best could get antibiotics to market faster and...rk best," Derendorf said, "and you'd find the best dose much faster than just by going by trial and error or by using some of the traditional ways." Conside...Gene therapy cures inherited liver disease in rats
HOUSTON--(March 7, 2005) -- A single dose of gene-virus combination cured rats of a inherited liver disease in which lack of a gene causes the accumulation of bilirubin which, untreated, results in jaundice and brain damage, said researchers at Baylor College of Medicine in a report in the P...JCI table of contents, April 1, 2005
...ion of PLK-1 in bladder cancer cells in a time and dose dependent fashion. Intravesical administration of the PLK-1 inhibitor reduced cell proliferation and killed cancer cells. To validate the efficacy of the treatment in vivo, mice were implanted with bladder cancer cells, and PLK-1 siRNA prevented th...Blocking neurodegeneration by radiation and bone marrow transfer prevents inherited glaucoma in mice
...d 5- to 8-week-old DBA/2J mice with a single, high dose of gamma radiation, together with bone marrow transfer. When they examined the mice at 12-14 months--an age at which most DBA/2J mice have advanced glaucoma--the researchers were amazed to find that the vast majority of mice did not have glaucoma. T...Blocking PLK-1 to beat bladder cancer
...ion of PLK-1 in bladder cancer cells in a time and dose dependent fashion. Intravesical administration of the PLK-1 inhibitor reduced cell proliferation and killed cancer cells. To validate the efficacy of the treatment in vivo, mice were implanted with bladder cancer cells, and PLK-1 siRNA prevented th...Anti cancer virotherapy well tolerated in first human administration, research finds
...ence that this research team had injected a single dose of Coxsackie A21 (CVA21) virus directly into the a...findings suggested that administration of a single dose of CVA21 directly into a cancerous tumour was well tolerated. "Administration of CVA21 may be of pot...Studies expand understanding of X chromosome
...oding for key proteins that are required in double dose were transferred from the X chromosome to other chromosomes during the course of mammalian evolution. Despite its relatively low gene density, the X chromosome holds a prominent place in the study and understanding of human disease. This arises from...JCI table of contents April 1, 2005
...e a new mouse model that mimics the effects of low dose aspirin to explore how such therapy would impact b...have significant value in studying the role of low dose aspirin in several pathological conditions, such as preeclampsia, thrombosis and inflammation. The...Birthing a new model of aspirin therapy in preeclampsia
...e a new mouse model that mimics the effects of low dose aspirin to explore how such therapy would impact b...have significant value in studying the role of low dose aspirin in several pathological conditions, such as preeclampsia, thrombosis and inflammation. The...Study supports use of aspirin in treating pregnancy disorder
...nificant value in studying the implications of low dose aspirin in several pathological conditions, such as pre-eclampsia, thrombosis, and inflammatory disorders," says Dr. Funk. "We're hopeful that our model will lead the way to further treatment options for these debilitating conditions."...Study finds anticonvulsant drug poses greater birth-defect risk than suspected
... other malformations had all taken the recommended dose of folic acid." Holmes is a professor of Pediatrics at Harvard Medical School. Co-authors of the Neurology report are first author Diego Wyszynski, MD, PhD, of Boston University School of Medicine and Public Health; Maya Nambisian, MPH, and Triptaa ...Gene variations explain drug dose required to control seizures
...y carry might enable doctors to better predict the dose of drugs necessary to control their seizures, sugg...o a lengthy process of trial and error to find the dose of anti-epilepsy drugs appropriate for them. The researchers found that variants of two genes were m...Aspirin is safer than warfarin and just as effective for treating blocked arteries in the brain
... requires complicated and expensive monitoring and dose adjustments," says John R. Marler, M.D., the Assoc... best option in those conditions, he cautions. The dose of aspirin used in this study 1300 mg is much higher than the daily doses typically prescribed, wh...New hope for Chagas disease treatment
...nd death. Importantly, TAK-187 was effective at a dose that was both 10 times lower and administered less frequently than that of benznidazole. The researchers think this may be because the new compound is eliminated more slowly than benznidazole from the tr5eated animals and is also more resistant to me...JCI table of contents May 1, 2005
...n and protected the mice from exposure to a deadly dose of the bacteria. Importantly, the mice could be repeatedly given the vaccine and the immune response against P. aeruginosa was boosted. Usually, adenovirus vectors do not allow for repeated infection. These results may be useful in the development ...New vaccine means bye-bye to bacteria in the lung
...n and protected the mice from exposure to a deadly dose of the bacteria. Importantly, the mice could be repeatedly given the vaccine and the immune response against P. aeruginosa was boosted. Usually, adenovirus vectors do not allow for repeated infection. These results may be useful in the development ...Was Agns Sorel, the first official royal mistress of France, poisoned?
... taking medicines and that she ingested too high a dose of these, which produced her death. Other possibilities include the fact that mercury appeared as a result of mummification or contamination from the surrounding environment. It is also a hypothesis that she would have had an intake of these metals t...